Search Results - "Leahy, Sophie"
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Associations between circadian alignment and cognitive functioning in a nationally representative sample of older adults
Published in Scientific reports (12-06-2024)“…Proper alignment of activity-rest and light–dark patterns allows for healthy bodily functions to occur at optimal times of the day. Disruptions to this…”
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Tailored lighting intervention (TLI) for improving sleep-wake cycles in older adults living with dementia
Published in Frontiers in physiology (18-12-2023)“…Sleep disturbance is a hallmark of Alzheimer's disease and related dementias, and caregiver stress caused by patients' nighttime wandering, injuries, and…”
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Inner retinal oxygen delivery and metabolism in progressive stages of diabetic retinopathy
Published in Scientific reports (22-02-2024)“…Previous studies have reported increased retinal venous oxygen saturation and decreased retinal blood flow and oxygen metabolism in non-proliferative diabetic…”
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Retinal Oxygen Delivery, Metabolism, and Extraction Fraction during Long-Term Bilateral Common Carotid Artery Occlusion in Rats
Published in Scientific reports (25-06-2020)“…Retinal functional, biochemical, and anatomical changes have been previously reported in long-term experimental permanent bilateral common carotid artery…”
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Retinal Vascular Physiology Biomarkers in a 5XFAD Mouse Model of Alzheimer's Disease
Published in Cells (Basel, Switzerland) (04-08-2022)“…Alzheimer's disease (AD) is a neurodegenerative disorder that affects the brain and retina and lacks reliable biomarkers for early diagnosis. As amyloid beta…”
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Retinal Oxygen Delivery and Metabolism Response to Hyperoxia During Bilateral Common Carotid Artery Occlusion in Rats
Published in Investigative ophthalmology & visual science (01-06-2022)“…PurposeThe purpose of the current study was to test the hypothesis that responses of total retinal blood flow (TRBF), inner retinal oxygen delivery (DO2),…”
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Impairments of retinal hemodynamics and oxygen metrics in ocular hypertension-induced ischemia-reperfusion
Published in Experimental eye research (01-12-2022)“…Ischemia-reperfusion (I/R) is an established model for retinal neurodegeneration. However, there is limited knowledge of retinal physiological metrics and…”
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Assessment of retinal oxygen metabolism, visual function, thickness and degeneration markers after variable ischemia/reperfusion in rats
Published in Experimental eye research (01-12-2021)“…After total retinal ischemia induced experimentally by ophthalmic vessel occlusion followed by reperfusion, studies have reported alterations in retinal oxygen…”
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The accumulated oxygen deficit as an indicator of the ischemic retinal insult
Published in Experimental eye research (01-05-2023)“…We here attempt to improve quantification of the ischemic retinal insult, that is, what is imposed on the retinal tissue by ischemia, especially in…”
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Alterations in retinal pulse wave velocity under experimental ocular hypertension
Published in Microvascular research (01-07-2023)“…Impairments of blood flow and autoregulation have been implicated in diabetic retinopathy and glaucoma. Thus, identifying biomarkers of retinal vascular…”
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Control of retinal blood flow levels by selected combinations of cervical arterial ligations in rat
Published in Experimental eye research (01-08-2020)“…The effect of various combinations of cervical arterial ligations (Combinations) on retinal blood flow (RBF) levels is not known in rats. We hypothesized: 1)…”
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Assessment of inner retinal oxygen metrics and thickness in a mouse model of inherited retinal degeneration
Published in Experimental eye research (01-04-2021)“…The retinal degeneration 1 (rd1) mouse is a well-established model of inherited retinal degeneration, displaying photoreceptor degeneration and retinal…”
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Relation of Retinal Oxygen Measures to Electrophysiology and Survival Indicators after Permanent, Incomplete Ischemia in Rats
Published in Translational stroke research (01-12-2020)“…Studies in experimental ischemia models by permanent bilateral common carotid artery occlusion (BCCAO) have reported reduced retinal electrophysiological…”
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Variability of Retinal Oxygen Metrics in Healthy and Diabetic Subjects
Published in Translational vision science & technology (18-10-2021)“…PurposePrevious studies have reported alterations in total retinal blood flow (TRBF), oxygen delivery (DO2), oxygen metabolism (MO2), and oxygen extraction…”
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Relating Retinal Vascular Oxygen Saturation and Microvasculature Morphology at Progressive Stages of Diabetic Retinopathy
Published in Translational vision science & technology (04-05-2021)“…PurposeDiabetic retinopathy (DR) is a common cause of vision loss in working age adults and presents changes in retinal vessel oxygenation and morphology. The…”
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