Search Results - "Leahy, Kathleen M."

Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration by Oh, Young Mi, Mahar, Marcus, Ewan, Eric E., Leahy, Kathleen M., Zhao, Guoyan, Cavalli, Valeria

“…Injured peripheral sensory neurons switch to a regenerative state after axon injury, which requires transcriptional and epigenetic changes. However, the roles…”
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Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo by Fleming, Heather E, Janzen, Viktor, Lo Celso, Cristina, Guo, Jun, Leahy, Kathleen M, Kronenberg, Henry M, Scadden, David T

“…Wingless (Wnt) is a potent morphogen demonstrated in multiple cell lineages to promote the expansion and maintenance of stem and progenitor cell populations…”
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Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development by Luo, Xianmin, Fu, Yujie, Loza, Andrew J., Murali, Bhavna, Leahy, Kathleen M., Ruhland, Megan K., Gang, Margery, Su, Xinming, Zamani, Ali, Shi, Yu, Lavine, Kory J., Ornitz, David M., Weilbaecher, Katherine N., Long, Fanxin, Novack, Deborah V., Faccio, Roberta, Longmore, Gregory D., Stewart, Sheila A.

“…More than 85% of advanced breast cancer patients suffer from metastatic bone lesions, yet the mechanisms that facilitate these metastases remain poorly…”
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Phase II Study of Dasatinib in Relapsed or Refractory Chronic Lymphocytic Leukemia by AMREIN, Philip C, ATTAR, Eyal C, HASSERJIAN, Robert P, WERNER, Lillian, NEUBERG, Donna, BROWN, Jennifer R, TAKVORIAN, Tak, HOCHBERG, Ephraim P, BALLEN, Karen K, LEAHY, Kathleen M, FISHER, David C, LACASCE, Ann S, JACOBSEN, Eric D, ARMAND, Philippe

“…Chronic lymphocytic leukemia (CLL) cells treated with dasatinib in vitro undergo apoptosis via inhibition of Lyn kinase. Thus, in this study we tested the…”
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Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature by Schleicher, Stephen M, Thotala, Dinesh K, Linkous, Amanda G, Hu, Rong, Leahy, Kathleen M, Yazlovitskaya, Eugenia M, Hallahan, Dennis E

“…Despite wide margins and high dose irradiation, unresectable malignant glioma (MG) is less responsive to radiation and is uniformly fatal. We previously found…”
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Pharmacology of celecoxib in rat brain after kainate administration by Ciceri, Paola, Zhang, Yan, Shaffer, Alex F, Leahy, Kathleen M, Woerner, Mark B, Smith, Walter G, Seibert, Karen, Isakson, Peter C

“…Prostaglandin E(2) (PGE(2)) is the major prostaglandin produced both centrally and in the periphery in models of acute and chronic inflammation, and its…”
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Quantitative ex vivo detection of rodent retinal ganglion cells by immunolabeling Brn-3b by Leahy, Kathleen M, Ornberg, Richard L, Wang, Yu, Zhu, Yanli, Gidday, Jeffrey M, Connor, Jane R, Wax, Martin B

“…To evaluate the neuroprotective potential of drug candidates to treat human glaucoma, a short-term rodent model of retinal ganglion cell death was employed…”
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Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo by LEAHY, Kathleen M, ORNBERG, Richard L, YU WANG, ZWEIFEL, Ben S, KOKI, Alane T, MASFERRER, Jaime L

“…Cyclooxygenase-2 (COX-2) is expressed within neovascular structures that support many human cancers. Inhibition of COX-2 by celecoxib delays tumor growth and…”
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A selective and oral small molecule inhibitor of vascular epithelial growth factor receptor (VEGFR)-2 and VEGFR-1 inhibits neovascularization and vascular permeability by Patel, Neela, Sun, Li, Moshinsky, Deborah, Chen, Hui, Leahy, Kathleen M, Le, Phuong, Moss, Katherine G, Wang, Xueyan, Rice, Audie, Tam, Danny, Laird, A Douglas, Yu, Xiaoming, Zhang, Qingling, Tang, Cho, McMahon, Gerald, Howlett, Anthony

“…Vascular endothelial growth factor (VEGF) is a key driver of the neovascularization and vascular permeability that leads to the loss of visual acuity in…”
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Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors by MASFERRER, J. L, LEAHY, K. M, KOKI, A. T, ZWEIFEL, B. S, SETTLE, S. L, WOERNER, B. M, EDWARDS, D. A, FLICKINGER, A. G, MOORE, R. J, SEIBERT, K

“…We provide evidence that cyclooxygenase (COX)-2-derived prostaglandins contribute to tumor growth by inducing newly formed blood vessels (neoangiogenesis) that…”
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Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats by GRUBBS, Clinton J, LUBET, Ronald A, KOKI, Alane T, LEAHY, Kathleen M, MASFERRER, Jaime L, STEELE, Vernon E, KELLOFF, Gary J, HILL, D. L, SEIBERT, Karen

“…Epidemiological studies have shown that nonsteroidal anti-inflammatory drugs (NSAIDs) may have a role in the prevention of human cancers. A number of…”
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Selective Inhibition of Inducible Cyclooxygenase 2 in vivo is Antiinflammatory and Nonulcerogenic by MASFERRER, J. L, ZWEIFEL, B. S, MANNING, P. T, HAUSER, S. D, LEAHY, K. M, SMITH, W. G, ISAKSON, P. C, SEIBERT, K

“…We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces…”
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Upregulation of COX-2 during cardiac allograft rejection by XIAOCHUN YANG, NINSHENG MA, GREGORY, S, CANNON, P. J, SZABOLCS, M. J, JING ZHONG, ATHAN, E, SCIACCA, R. R, MICHLER, R. E, ANDERSON, G. D, WIESE, J. F, LEAHY, K. M

“…The hypothesis that cyclooxygenase-2 (COX-2) is involved in the myocardial inflammatory response during cardiac allograft rejection was investigated using a…”
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Brain natriuretic peptides: differential localization of a new family of neuropeptides by Saper, C B, Hurley, K M, Moga, M M, Holmes, H R, Adams, S A, Leahy, K M, Needleman, P

“…Brain natriuretic peptide (BNP) is a recently discovered neuropeptide, isolated from the porcine brain, that is highly homologous to atriopeptin (AP), the…”
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Response to Dasatinib In Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Correlates with p-Lyn and p-Syk by Amrein, Philip C., Attar, Eyal C, Takvorian, Tak, Hochberg, Ephraim, Ballen, Karen K, Leahy, Kathleen M, Fisher, David C., LaCasce, Ann, Jacobsen, Eric D, Armand, Philippe, Hasserjian, Robert, Werner, Lillian, Neuberg, Donna, Brown, Jennifer R

“…Abstract 2457 Preclinical studies have shown that CLL cells overexpress Lyn kinase, and in vitro inhibition of Lyn kinase leads to apoptosis of the CLL cells…”
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Dasatinib Has Activity in Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL/SLL), a Phase II Trial by Amrein, Philip C., Attar, Eyal, Takvorian, Tak, Hochberg, Ephraim, Ballen, Karen K., Leahy, Kathleen M., Neuberg, Donna, Brown, Jennifer R.

“…Background: Preclinical studies have shown that CLL cells overexpress lyn kinase protein, and in vitro inhibition of lyn kinase leads to apoptosis of the CLL…”
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Cellular interactions and exaggerated arachidonic acid metabolism in rabbit renal injury by Jonas, P E, Leahy, K M, DeSchryver-Kecskemeti, K, Needleman, P

“…Cell cultures from explants of the rabbit hydronephrotic kidney (HNK) cortex consisted of fibroblasts and an esterase-positive cell that phagocytizes zymosan…”
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Nursing Service in a Tuberculosis Sanatorium by Blackman, Helen, Leahy, Kathleen M.

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Development, validation and application of an enzyme immunoassay (EIA) of atriopeptin by McLaughlin, L L, Wei, Y F, Stockmann, P T, Leahy, K M, Needleman, P, Grassi, J, Pradelles, P

“…A rapid, convenient, and sensitive enzyme immunoassay (EIA) for atriopeptin (AP) has been developed. The tracer-ligand for the assay is the 24-amino acid…”
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Reversible Induction of Right Ventricular Atriopeptin Synthesis in Hypertrophy Due to Hypoxia by Stockmann, Paul T, Will, Donald H, Sides, Steven D, Brunnert, Steven R, Wilner, George D, Leahy, Kathleen M, Wiegand, Roger C, Needleman, Philip

“…Right ventricular hypertrophy produced in rats exposed to 10% oxygen for 3 weeks resulted in a ninefold increase in atriopeptin immunoreactivity (APir) and a…”
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