Search Results - "Leachman, Sancy A"

Reply to Reimann et al by Clarke, Loren E., Leachman, Sancy A.

Get full text

Lymphatic Vessels, Inflammation, and Immunity in Skin Cancer by Lund, Amanda W, Medler, Terry R, Leachman, Sancy A, Coussens, Lisa M

“…Skin is a highly ordered immune organ that coordinates rapid responses to external insult while maintaining self-tolerance. In healthy tissue, lymphatic…”
Get more information

Epistatic and Combinatorial Effects of Pigmentary Gene Mutations in the Domestic Pigeon by Domyan, Eric T., Guernsey, Michael W., Kronenberg, Zev, Krishnan, Shreyas, Boissy, Raymond E., Vickrey, Anna I., Rodgers, Clifford, Cassidy, Pamela, Leachman, Sancy A., Fondon, John W., Yandell, Mark, Shapiro, Michael D.

“…Understanding the molecular basis of phenotypic diversity is a critical challenge in biology, yet we know little about the mechanistic effects of different…”
Get full text

Influence of the COVID-19 pandemic on sun habits of patients with melanoma: a cross-sectional study by Trepanowski, Nicole, Hathaway, Cassandra A., Chang, Michael S., Hay, Jennifer L., Samatham, Ravi, Geller, Alan C., Swetter, Susan M., Tworoger, Shelley S., Kanetsky, Peter A., Leachman, Sancy A., Hartman, Rebecca I.

Get full text

A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita by Eliason, Mark J., MD, Leachman, Sancy A., MD, PhD, Feng, Bing-jian, PhD, Schwartz, Mary E., AA, Hansen, C. David, MD

“…Background Pachyonychia congenita (PC) is a group of autosomal dominant keratinizing disorders caused by a mutation in one of 4 keratin genes. Previous…”
Get full text

First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder by Leachman, Sancy A, Hickerson, Robyn P, Schwartz, Mary E, Bullough, Emily E, Hutcherson, Stephen L, Boucher, Kenneth M, Hansen, C David, Eliason, Mark J, Srivatsa, G Susan, Kornbrust, Douglas J, Smith, Frances JD, McLean, WH Irwin, Milstone, Leonard M, Kaspar, Roger L

“…The rare skin disorder pachyonychia congenita (PC) is an autosomal dominant syndrome that includes a disabling plantar keratoderma for which no satisfactory…”
Get full text

Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma by Femel, Julia, Hill, Cameron, Illa Bochaca, Irineu, Booth, Jamie L, Asnaashari, Tina G, Steele, Maria M, Moshiri, Ata S, Do, Hyungrok, Zhong, Judy, Osman, Iman, Leachman, Sancy A, Tsujikawa, Takahiro, White, Kevin P, Chang, Young H, Lund, Amanda W

“…Quantitative, multiplexed imaging is revealing complex spatial relationships between phenotypically diverse tumor infiltrating leukocyte populations and their…”
Get full text

The Mole Mapper Study, mobile phone skin imaging and melanoma risk data collected using ResearchKit by Webster, Dan E., Suver, Christine, Doerr, Megan, Mounts, Erin, Domenico, Lisa, Petrie, Tracy, Leachman, Sancy A., Trister, Andrew D., Bot, Brian M.

“…Sensor-embedded phones are an emerging facilitator for participant-driven research studies. Skin cancer research is particularly amenable to this approach, as…”
Get full text

Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita by Leachman, Sancy A, Hickerson, Robyn P, Hull, Peter R, Smith, Frances J.D, Milstone, Leonard M, Lane, E. Birgitte, Bale, Sherri J, Roop, Dennis R, McLean, W.H. Irwin, Kaspar, Roger L

“…Summary The field of science and medicine has experienced a flood of data and technology associated with the human genome project. Over 10,000 human diseases…”
Get full text

Prognostic gene expression profiling in melanoma: necessary steps to incorporate into clinical practice by Grossman, Douglas, Kim, Caroline C, Hartman, Rebecca I, Berry, Elizabeth, Nelson, Kelly C, Okwundu, Nwanneka, Curiel-Lewandrowski, Clara, Leachman, Sancy A, Swetter, Susan M

“…Prognostic gene expression profiling (GEP) tests for cutaneous melanoma (CM) are not recommended in current guidelines outside of a clinical trial. However,…”
Get full text

Parent and child perspectives on family interactions related to melanoma risk and prevention after CDKN2A/p16 testing of minor children by Wu, Yelena P., Aspinwall, Lisa G., Parsons, Bridget, Stump, Tammy K., Nottingham, Katy, Kohlmann, Wendy, Champine, Marjan, Cassidy, Pamela, Leachman, Sancy A.

“…Predispositional genetic testing of children for adult-onset health risks is typically only used when prevention and screening measures have utility during…”
Get full text

Isolation of circulating microRNAs from microvesicles found in human plasma by Quackenbush, John F, Cassidy, Pamela B, Pfeffer, Lawrence M, Boucher, Kenneth M, Hawkes, Jason E, Pfeffer, Susan R, Kopelovich, Levy, Leachman, Sancy A

“…Intact miRNAs can be isolated from the circulation in significant quantities despite the presence of extremely high levels of RNase activity. The remarkable…”
Get more information

Use of Self-Delivery siRNAs to Inhibit Gene Expression in an Organotypic Pachyonychia Congenita Model by Hickerson, Robyn P., Flores, Manuel A., Leake, Devin, Lara, Maria F., Contag, Christopher H., Leachman, Sancy A., Kaspar, Roger L.

“…Although RNA interference offers therapeutic potential for treating skin disorders, delivery hurdles have hampered clinical translation. We have recently…”
Get full text

Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients by Hickerson, Robyn P, Leake, Devin, Pho, Lana N, Leachman, Sancy A, Kaspar, Roger L

“…Abstract Background The macrolide sirolimus (rapamycin) selectively blocks translation of mRNAs containing a terminal 5′ oligopyrimidine (TOP) tract by…”
Get full text

CDKN2A/p16 Genetic Test Reporting Improves Early Detection Intentions and Practices in High-Risk Melanoma Families by ASPINWALL, Lisa G, LEAF, Samantha L, DOLA, Erin R, KOHLMANN, Wendy, LEACHMAN, Sancy A

“…Genetic testing for melanoma has yet to enter routine clinical use because of the scarcity of available data on the effect of test reporting. A prospective…”
Get full text

Understanding Skin Screening Practices Among Children at Elevated Risk for Melanoma to Inform Interventions for Melanoma Prevention and Control by Parsons, Bridget G., Hay, Jennifer L., Aspinwall, Lisa G., Zaugg, Kelsey, Zhu, Angela, Mooney, Ryan H., Klein, Stephanie Z., Grossman, Douglas, Leachman, Sancy A., Wu, Yelena P.

“…Melanoma is the deadliest form of skin cancer. Screening can aid in early disease detection, when treatment is more effective. Although there are currently no…”
Get full text

Clinical challenges in interpreting multiple pathogenic mutations in single patients by Slaught, Christa, Berry, Elizabeth G, Bacik, Lindsay, Skalet, Alison H, Anadiotis, George, Tuohy, Therese, Leachman, Sancy A

“…In the past two decades, genetic testing for cancer risk assessment has entered mainstream clinical practice due to the availability of low-cost panels of…”
Get full text

Medicine: The final frontier in cancer diagnosis by Leachman, Sancy A, Merlino, Glenn

Get full text

Patterns of failure and predictors of outcome in cutaneous malignant melanoma of the scalp by Terakedis, Breanne E., MD, Anker, Christopher J., MD, Leachman, Sancy A., MD, PhD, Andtbacka, Robert H.I., MD, Bowen, Glen M., MD, Sause, William T., MD, Grossmann, Kenneth F., MD, PhD, Bowles, Tawnya L., MD, Noyes, R. Dirk, MD, Hitchcock, Ying J., MD, Boucher, Kenneth M., PhD, Shrieve, Dennis C., MD, PhD

“…Background Patients with melanoma of the scalp may have higher failure (recurrence) rates than melanoma of other body sites. Objective We sought to…”
Get full text

Cellular and ultrastructural characterization of the grey-morph phenotype in southern right whales (Eubalaena australis) by Eroh, Guy D, Clayton, Fred C, Florell, Scott R, Cassidy, Pamela B, Chirife, Andrea, Marón, Carina F, Valenzuela, Luciano O, Campbell, Michael S, Seger, Jon, Rowntree, Victoria J, Leachman, Sancy A

“…Southern right whales (SRWs, Eubalena australis) are polymorphic for an X-linked pigmentation pattern known as grey morphism. Most SRWs have completely black…”
Get full text