Search Results - "Leach, Robert"

AJSM at 50 by Leach, Robert E.

Get full text

Interpreting 16S metagenomic data without clustering to achieve sub-OTU resolution by Tikhonov, Mikhail, Leach, Robert W, Wingreen, Ned S

“…The standard approach to analyzing 16S tag sequence data, which relies on clustering reads by sequence similarity into Operational Taxonomic Units (OTUs),…”
Get full text

Filoviruses are ancient and integrated into mammalian genomes by Taylor, Derek J, Leach, Robert W, Bruenn, Jeremy

“…Hemorrhagic diseases from Ebolavirus and Marburgvirus (Filoviridae) infections can be dangerous to humans because of high fatality rates and a lack of…”
Get full text

Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation by Dai, Wei, Li, Ang, Yu, Nathan J., Nguyen, Thao, Leach, Robert W., Wühr, Martin, Kleiner, Ralph E.

“…Epitranscriptomic RNA modifications can regulate RNA activity; however, there remains a major gap in our understanding of the RNA chemistry present in…”
Get full text

In Vitro Selection with a Site-Specifically Modified RNA Library Reveals the Binding Preferences of N6‑Methyladenosine Reader Proteins by Arguello, A. Emilia, Leach, Robert W, Kleiner, Ralph E

“…Epitranscriptomic RNA modifications can serve as recognition elements for the recruitment of effector proteins (i.e., “readers”) to modified transcripts. While…”
Get full text

Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP by Garcia, P. Daniela, Leach, Robert W., Wadsworth, Gable M., Choudhary, Krishna, Li, Hua, Aviran, Sharon, Kim, Harold D., Zakian, Virginia A.

“…RNase P and MRP are highly conserved, multi-protein/RNA complexes with essential roles in processing ribosomal and tRNAs. Three proteins found in both…”
Get full text

Facilitates Chromatin Transcription Complex Is an “Accelerator” of Tumor Transformation and Potential Marker and Target of Aggressive Cancers by Garcia, Henry, Miecznikowski, Jeffrey C., Safina, Alfiya, Commane, Mairead, Ruusulehto, Anja, Kilpinen, Sami, Leach, Robert W., Attwood, Kristopher, Li, Yan, Degan, Seamus, Omilian, Angela R., Guryanova, Olga, Papantonopoulou, Olympia, Wang, Jianmin, Buck, Michael, Liu, Song, Morrison, Carl, Gurova, Katerina V.

“…The facilitates chromatin transcription (FACT) complex is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT was…”
Get full text

Full-Coverage Chiropractic in Medicare: A Proposal to Eliminate Inequities, Improve Outcomes, and Reduce Health Disparities Without Increasing Overall Program Costs by Leach, Robert A.

“…The purpose of this article is to discuss evidence that supports the resolution of inequities for Medicare beneficiaries who receive chiropractic care…”
Get full text

Doing the Same Thing and Expecting a Different Outcome: It Is Time for a Questioning Philosophy and Theory-Driven Chiropractic Research by Leach, Robert A.

“…The purpose of this commentary is to discuss the philosophical and hypothetical underpinnings of chiropractic and consider whether there is a need for…”
Get full text

In Vitro Selection with a Site-Specifically Modified RNA Library Reveals the Binding Preferences of N 6 -Methyladenosine Reader Proteins by Arguello, A Emilia, Leach, Robert W, Kleiner, Ralph E

“…Epitranscriptomic RNA modifications can serve as recognition elements for the recruitment of effector proteins (i.e., "readers") to modified transcripts. While…”
Get full text

Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses by Douam, Florian, Ziegler, Carly G. K., Hrebikova, Gabriela, Fant, Bruno, Leach, Robert, Parsons, Lance, Wang, Wei, Gaska, Jenna M., Winer, Benjamin Y., Heller, Brigitte, Shalek, Alex K., Ploss, Alexander

“…Mice engrafted with components of a human immune system have become widely-used models for studying aspects of human immunity and disease. However, a defined…”
Get full text

Src promotes castration-recurrent prostate cancer through androgen receptor-dependent canonical and non-canonical transcriptional signatures by Chattopadhyay, Indranil, Wang, Jianmin, Qin, Maochun, Gao, Lingqiu, Holtz, Renae, Vessella, Robert L, Leach, Robert W, Gelman, Irwin H

“…Progression of prostate cancer (PC) to castration-recurrent growth (CRPC) remains dependent on sustained expression and transcriptional activity of the…”
Get full text

European Society of Emergency Medicine position paper on the 1-hour sepsis bundle of the Surviving Sepsis Campaign: expression of concern by Freund, Yonathan, Khoury, Abdo, Möckel, Martin, Karamercan, Mehmet, Dodt, Christoph, Leach, Robert, Bloom, Ben, Garcia-Castrillo, Luis

“…In 2018 the Surviving Sepsis Campaign issued new guidance with a revised version of their sepsis bundle. Instead of the 2016 3-hour sepsis bundle, the…”
Get full text

Whole-genome sequencing identifies genomic heterogeneity at a nucleotide and chromosomal level in bladder cancer by Morrison, Carl D, Liu, Pengyuan, Woloszynska-Read, Anna, Zhang, Jianmin, Luo, Wei, Qin, Maochun, Bshara, Wiam, Conroy, Jeffrey M, Sabatini, Linda, Vedell, Peter, Xiong, Donghai, Liu, Song, Wang, Jianmin, Shen, He, Li, Yinwei, Omilian, Angela R, Hill, Annette, Head, Karen, Guru, Khurshid, Kunnev, Dimiter, Leach, Robert, Eng, Kevin H, Darlak, Christopher, Hoeflich, Christopher, Veeranki, Srividya, Glenn, Sean, You, Ming, Pruitt, Steven C, Johnson, Candace S, Trump, Donald L

“…Using complete genome analysis, we sequenced five bladder tumors accrued from patients with muscle-invasive transitional cell carcinoma of the urinary bladder…”
Get full text

Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins by Kunnev, Dimiter, Freeland, Amy, Qin, Maochun, Leach, Robert W, Wang, Jianmin, Shenoy, Rajani M, Pruitt, Steven C

“…Minichromosome maintenance (MCM) proteins are loaded onto chromatin during G1-phase and define potential locations of DNA replication initiation. MCM protein…”
Get full text

COVID-19 Infectious Disease Prevention and Mitigation Practices by Chiropractic Physicians and Licensed Massage Therapists in Mississippi: A Needs Assessment to Inform Health Education and Promotion by Leach, Robert A., Ndetan, Harrison, King, Jeffrey A., Evans, Marion W.

“…The purpose of this study was to assess self-reported infection prevention processes and their effect on businesses of chiropractic doctors (DCs) and licensed…”
Get full text

Domain movements of the enhancer-dependent sigma factor drive DNA delivery into the RNA polymerase active site: insights from single molecule studies by Sharma, Amit, Leach, Robert N., Gell, Christopher, Zhang, Nan, Burrows, Patricia C., Shepherd, Dale A., Wigneshweraraj, Sivaramesh, Smith, David Alastair, Zhang, Xiaodong, Buck, Martin, Stockley, Peter G., Tuma, Roman

“…Recognition of bacterial promoters is regulated by two distinct classes of sequence-specific sigma factors, σ70 or σ54, that differ both in their primary…”
Get full text

The Big Four-Oh by Reider, Bruce

Get full text

A vending machine coffee in an emergency department waiting room by Leach, Robert

Get full text

A quick Turkish coffee with EUSEM by Leach, Robert

Get full text