Search Results - "Leach, Prescott"

Modeling fragile X syndrome in the Fmr1 knockout mouse by Kazdoba, Tatiana M., Leach, Prescott T., Silverman, Jill L., Crawley, Jacqueline N.

“…Fragile X Syndrome (FXS) is a commonly inherited form of intellectual disability and one of the leading genetic causes for autism spectrum disorder. Clinical…”
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Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning by Gould, Thomas J., Leach, Prescott T.

“…•We examine the effects of nicotine on hippocampus-dependent learning through different stages of drug administration.•We examine how nicotine usurps the…”
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Thyroid hormone signaling: Contribution to neural function, cognition, and relationship to nicotine by Leach, Prescott T, Gould, Thomas J

“…Cigarette smoking is common despite its adverse effects on health, such as cardiovascular disease and stroke. Understanding the mechanisms that contribute to…”
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"Gadd45b" Knockout Mice Exhibit Selective Deficits in Hippocampus-Dependent Long-Term Memory by Leach, Prescott T, Poplawski, Shane G, Kenney, Justin W, Hoffman, Barbara, Liebermann, Dan A, Abel, Ted, Gould, Thomas J

“…Growth arrest and DNA damage-inducible [beta] ("Gadd45b") has been shown to be involved in DNA demethylation and may be important for cognitive processes…”
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Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo by McAvoy, Kathleen M, Rajamohamed Sait, Hameetha, Marsh, Galina, Peterson, Michael, Reynolds, Taylor L, Gagnon, Jake, Geisler, Sarah, Leach, Prescott, Roberts, Chris, Cahir-McFarland, Ellen, Ransohoff, Richard M, Crotti, Andrea

“…BIN1 is the most important risk locus for Late Onset Alzheimer's Disease (LOAD), after ApoE. BIN1 AD-associated SNPs correlate with Tau deposition as well as…”
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Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics by Kazdoba, Tatiana M, Leach, Prescott T, Yang, Mu, Silverman, Jill L, Solomon, Marjorie, Crawley, Jacqueline N

“…Animal models provide preclinical tools to investigate the causal role of genetic mutations and environmental factors in the etiology of autism spectrum…”
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Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors by Lotfipour, Shahrdad, Byun, Janet S, Leach, Prescott, Fowler, Christie D, Murphy, Niall P, Kenny, Paul J, Gould, Thomas J, Boulter, Jim

“…Baseline and nicotine-modulated behaviors were assessed in mice harboring a null mutant allele of the nicotinic acetylcholine receptor (nAChR) subunit gene α2…”
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c-Jun-N-terminal kinase 1 is necessary for nicotine-induced enhancement of contextual fear conditioning by Leach, Prescott T., Kenney, Justin W., Gould, Thomas J.

“…•JNK1 is critical for nicotine-enhanced contextual fear conditioning.•JNK1 WT mice show increased contextual memory in response to nicotine treatment.•JNK1 KO…”
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Structure-Based Design of an Iminoheterocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates by Mandal, Mihirbaran, Wu, Yusheng, Misiaszek, Jeffrey, Li, Guoqing, Buevich, Alexei, Caldwell, John P, Liu, Xiaoxiang, Mazzola, Robert D, Orth, Peter, Strickland, Corey, Voigt, Johannes, Wang, Hongwu, Zhu, Zhaoning, Chen, Xia, Grzelak, Michael, Hyde, Lynn A, Kuvelkar, Reshma, Leach, Prescott T, Terracina, Giuseppe, Zhang, Lili, Zhang, Qi, Michener, Maria S, Smith, Brad, Cox, Kathleen, Grotz, Diane, Favreau, Leonard, Mitra, Kaushik, Kazakevich, Irina, McKittrick, Brian A, Greenlee, William, Kennedy, Matthew E, Parker, Eric M, Cumming, Jared N, Stamford, Andrew W

“…We describe successful efforts to optimize the in vivo profile and address off-target liabilities of a series of BACE1 inhibitors represented by 6 that…”
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The Effects of Acute Nicotine, Chronic Nicotine, and Withdrawal From Chronic Nicotine on Performance of a Cued Appetitive Response by Leach, Prescott T, Cordero, Kristy A, Gould, Thomas J

“…Nicotine is a widely used addictive drug, with an estimated 73 million Americans 12 years of age or older having used a tobacco product in the last month,…”
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Stronger learning recruits additional cell-signaling cascades: c-Jun-N-terminal kinase 1 (JNK1) is necessary for expression of stronger contextual fear conditioning by Leach, Prescott T., Kenney, Justin W., Gould, Thomas J.

“…•Stronger learning recruits additional cell signaling cascades.•JNK1 is differentially involved in weak versus strong learning.•WT, but not JNK1 KO, mice show…”
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Withdrawal From Chronic Nicotine Reduces Thyroid Hormone Levels and Levothyroxine Treatment Ameliorates Nicotine Withdrawal-Induced Deficits in Hippocampus-Dependent Learning in C57BL/6J Mice by Leach, Prescott T., Holliday, Erica, Kutlu, Munir G., Gould, Thomas J.

“…Cigarette smoking alters a variety of endocrine systems including thyroid hormones. Altered thyroid hormone signaling may lead to a subclinical or overt…”
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Thyroid receptor β involvement in the effects of acute nicotine on hippocampus-dependent memory by Leach, Prescott T., Kenney, Justin W., Connor, David A., Gould, Thomas J.

“…Cigarette smoking is common despite adverse health effects. Nicotine's effects on learning may contribute to addiction by enhancing drug-context associations…”
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Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme‑1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation by Mandal, Mihirbaran, Zhu, Zhaoning, Cumming, Jared N, Liu, Xiaoxiang, Strickland, Corey, Mazzola, Robert D, Caldwell, John P, Leach, Prescott, Grzelak, Michael, Hyde, Lynn, Zhang, Qi, Terracina, Giuseppe, Zhang, Lili, Chen, Xia, Kuvelkar, Reshma, Kennedy, Matthew E, Favreau, Leonard, Cox, Kathleen, Orth, Peter, Buevich, Alexei, Voigt, Johannes, Wang, Hongwu, Kazakevich, Irina, McKittrick, Brian A, Greenlee, William, Parker, Eric M, Stamford, Andrew W

“…On the basis of our observation that the biaryl substituent of iminopyrimidinone 7 must be in a pseudoaxial conformation to occupy the contiguous S1–S3…”
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Nicotine ameliorates NMDA receptor antagonist-induced deficits in contextual fear conditioning through high-affinity nicotinic acetylcholine receptors in the hippocampus by André, Jessica M., Leach, Prescott T., Gould, Thomas J.

“…NMDA glutamate receptors (NMDARs) and nicotinic acetylcholine receptors (nAChRs) are both involved in learning and synaptic plasticity. Increasing evidence…”
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Nicotine shifts the temporal activation of hippocampal protein kinase A and extracellular signal-regulated kinase 1/2 to enhance long-term, but not short-term, hippocampus-dependent memory by Gould, Thomas J., Wilkinson, Derek S., Yildirim, Emre, Poole, Rachel L.F., Leach, Prescott T., Simmons, Steven J.

“…•Acute nicotine enhances hippocampus-dependent LTM but not STM.•Increased PKA activation is necessary for enhancement of LTM by acute nicotine.•Nicotine and…”
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Normal Performance of Fmr1 Mice on a Touchscreen Delayed Nonmatching to Position Working Memory Task by Leach, Prescott T, Hayes, Jane, Pride, Michael, Silverman, Jill L, Crawley, Jacqueline N

“…Fragile X syndrome is a neurodevelopmental disorder characterized by mild-to-severe cognitive deficits. The complete absence of Fmr1 and its protein product in…”
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Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination by Hodgson, Robert A., Hyde, Lynn A., Guthrie, Donald H., Cohen-Williams, Mary E., Leach, Prescott T., Kazdoba, Tatiana M., Bleickardt, Carina J., Lu, Sherry X., Parker, Eric M., Varty, Geoffrey B.

“…Metabotropic glutamate receptor 1 (mGluR1) antagonists interfere with learning and memory; however, their role in motor function is not well elucidated despite…”
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In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects by Cohen-Williams, Mary E., Leach, Prescott T., Del Vecchio, Robert A., Zhang, Qi, Hyde, Lynn A., Chen, Lei, Wong, Gwendolyn T., McHugh, Nansie A., Chen, Joseph, Higgins, Guy A., Asberom, Theodros, Li, Wei, Pissarnitski, Dmitri, Levitan, Diane, Nomeir, Amin A., Clader, John W., Zhang, Lili, Parker, Eric M.

“…Substantial evidence implicates β-amyloid (Aβ) peptides in the etiology of Alzheimer’s disease (AD). Aβ is produced by the proteolytic cleavage of the amyloid…”
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In Vivo Characterization of a Novel -Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects by Hyde, Lynn A., Zhang, Qi, Del Vecchio, Robert A., Leach, Prescott T., Cohen-Williams, Mary E., Chen, Lei, Wong, Gwendolyn T., McHugh, Nansie A., Chen, Joseph, Higgins, Guy A., Asberom, Theodros, Li, Wei, Pissarnitski, Dmitri, Levitan, Diane, Nomeir, Amin A., Clader, John W., Zhang, Lili, Parker, Eric M.

“…Substantial evidence implicates -amyloid (A) peptides in the etiology of Alzheimer’s disease (AD). A is produced by the proteolytic cleavage of the amyloid…”
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