Search Results - "Leach, Michael"

Dx by Leach, Michael J

Get full text

The Warmth of Her Light by Leach, Michael J.

“…This poem focuses on the hospitalization, death, and burial of a patient. (PsycInfo Database Record (c) 2022 APA, all rights reserved)…”
Get full text

Immune-Mediated Liver Effects Associated With Administration of a Human Anti-IL-21 Receptor Antibody (ATR-107) in Rats by Hu, Wenyue, Buetow, Bernard S., Sachdeva, Karuna, Leach, Michael W.

“…The toxicity of ATR-107, a human anti-interleukin-21 receptor (IL-21R) monoclonal antibody (mAb), was evaluated in CD-1 mice and cynomolgus monkeys after…”
Get full text

An Adaptive Motion Model for Person Tracking with Instantaneous Head-Pose Features by Baxter, Rolf H., Leach, Michael J. V., Mukherjee, Sankha S., Robertson, Neil M.

“…This letter presents novel behaviour-based tracking of people in low-resolution using instantaneous priors mediated by head-pose. We extend the Kalman Filter…”
Get full text

Factors Associated With Quality of Life Among People Living With a Stoma in Nonmetropolitan Areas by Ketterer, Sarah N., Leach, Michael J., Fraser, Caitlin

“…Interruption of gastrointestinal continuity through surgical formation of a stoma can be lifesaving. However, it is also typically associated with reduced…”
Get full text

Physical activity, obesity, and quality of life among rural Australian cancer survivors: a cross-sectional study by Leach, Michael J., Barber, Georgina, Monacella, Stephanie, Jamieson, Philip, Trinh, Thi, Vo, Ngan, Schmidt, Ulla, Byrne, Anny, Ristevski, Eli

“…Purpose We aimed to describe physical activity (PA), obesity, and quality of life (QoL) among rural Australian cancer survivors, assess whether total and…”
Get full text

N of 1 by Leach, Michael J.

Get full text

Translation of nonclinical to clinical safety findings for 27 biotherapeutics by Leach, Michael W., Rana, Payal, Hu, Wenyue, Mittapalli, Rajendar K., Pinkstaff, Jason, Potter, David, Qiu, Xing Min, Ramaiah, Lila, Rohde, Cynthia, Xia, Feng, Khan, K. Nasir

“…Human adverse drug reactions (ADRs), and in vivo nonclinical adverse and nonadverse findings, were identified in 27 biotherapeutic programs and placed into…”
Get full text

A data visualisation method for assessing exposure misclassification in case-crossover studies: the example of tricyclic antidepressants and the risk of hip fracture in older people by Leach, Michael J, Roughead, Elizabeth E, Pratt, Nicole L

“…The case-crossover design is suited to medication safety studies but is vulnerable to exposure misclassification. Using the example of tricyclic…”
Get full text

Longitudinal by Leach, Michael J

Get full text

A Villanelle on the Infinitesimal by Leach, Michael J.

Get full text

Regulatory Forum Opinion Piece: Differences between Protein-based Biologic Products (Biotherapeutics) and Chemical Entities (Small Molecules) of Relevance to the Toxicologic Pathologist by Leach, Michael W.

“…With the advances in cell culture methodologies and molecular biology that have occurred over the past several decades, biologics have become as common as…”
Get full text

Immunogenicity/Hypersensitivity of Biologics by Leach, Michael W., Rottman, James B., Hock, M. Benjamin, Finco, Deborah, Rojko, Jennifer L., Beyer, Joseph C.

“…This continuing education course was designed to provide an overview of the immunologic mechanisms involved in immunogenicity and hypersensitivity reactions…”
Get full text

A national survey of COVID-19 challenges, responses and effects in Australian general practice by Kippen, Rebecca, O'Sullivan, Belinda, Hickson, Helen, Leach, Michael, Wallace, Glen

“…A national cross-sectional online survey of Australian general practitioners was conducted in April and May 2020, with 572 respondents. The COVID-19 pandemic…”
Get more information

Contextual anomaly detection in crowded surveillance scenes by Leach, Michael J.V., Sparks, Ed.P., Robertson, Neil M.

“…•We propose a novel context aware anomaly detection process applied to human behaviour.•We evaluate our method upon 2 different datasets.•We utilise a novel…”
Get full text

Rural nurses’ self-rated knowledge and skills in pain, medication, symptom and emergency management in community-based palliative care: A cross-sectional survey by Khalil, Hanan, Leach, Michael J, Bolton, Ellen, Spargo, Melissa, Byrne, Anny, Ristevski, Eli

“…The assessment and management of pain and symptoms in community-based palliative care patients is a measure of quality in palliative care to indicate the…”
Get full text

Strategies and Recommendations for Using a Data‐Driven and Risk‐Based Approach in the Selection of First‐in‐Human Starting Dose: An International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Assessment by Leach, Michael W., Clarke, David O., Dudal, Sherri, Han, Chao, Li, Chunze, Yang, Zheng, Brennan, Frank R., Bailey, Wendy J., Chen, Yingxue, Deslandes, Antoine, Loberg, Lise I., Mayawala, Kapil, Rogge, Mark C., Todd, Marque, Chemuturi, Nagendra V.

“…Various approaches to first‐in‐human (FIH) starting dose selection for new molecular entities (NMEs) are designed to minimize risk to trial subjects. One…”
Get full text

Clostridium perfringens septicaemia by McIlwaine, Kathleen, Leach, Michael T. J.

Get full text

Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach by Chien, Hsiao-Tzu, Prior, Helen, Andrews, Laura, van Aerts, Leon, Cauvin, Annick, Clarke, David O., Datta, Kaushik, Dempster, Maggie, Dybdal, Noel, Freebern, Wendy, de Haan, Lolke, Herzyk, Danuta, Hey, Adam, Kissner, Thomas, Kronenberg, Sven, Leach, Michael W., Lee, Donna, Schutte, Katrin, Sewell, Fiona, Trouba, Kevin, Ulrich, Peter, Weir, Lucinda, van Meer, Peter

“…To support registration of monoclonal antibodies (mAbs) for chronic indications, 6-month toxicity studies have historically been conducted. Experience with mAb…”
Get full text

Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12 by McCaig, Alison M, Cosimo, Emilio, Leach, Michael T, Michie, Alison M

“…Chemokines and their ligands play a critical role in enabling chronic lymphocytic leukaemia (CLL) cells access to protective microenvironmental niches within…”
Get full text