Search Results - "Leach, G D"

CXCR2 inhibition suppresses acute and chronic pancreatic inflammation by Steele, Colin W, Karim, Saadia A, Foth, Mona, Rishi, Loveena, Leach, Joshua DG, Porter, Ross J, Nixon, Colin, Jeffry Evans, TR, Carter, C Ross, Nibbs, Robert JB, Sansom, Owen J, Morton, Jennifer P

“…Pancreatitis is a significant clinical problem and the lack of effective therapeutic options means that treatment is often palliative rather than curative. A…”
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Fumarate induces redox-dependent senescence by modifying glutathione metabolism by Zheng, Liang, Cardaci, Simone, Jerby, Livnat, MacKenzie, Elaine D., Sciacovelli, Marco, Johnson, T. Isaac, Gaude, Edoardo, King, Ayala, Leach, Joshua D. G., Edrada-Ebel, RuAngelie, Hedley, Ann, Morrice, Nicholas A., Kalna, Gabriela, Blyth, Karen, Ruppin, Eytan, Frezza, Christian, Gottlieb, Eyal

“…Mutations in the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase (FH) are associated with a highly malignant form of renal cancer. We combined…”
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CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma by Steele, Colin W., Karim, Saadia A., Leach, Joshua D.G., Bailey, Peter, Upstill-Goddard, Rosanna, Rishi, Loveena, Foth, Mona, Bryson, Sheila, McDaid, Karen, Wilson, Zena, Eberlein, Catherine, Candido, Juliana B., Clarke, Mairi, Nixon, Colin, Connelly, John, Jamieson, Nigel, Carter, C. Ross, Balkwill, Frances, Chang, David K., Evans, T.R. Jeffry, Strathdee, Douglas, Biankin, Andrew V., Nibbs, Robert J.B., Barry, Simon T., Sansom, Owen J., Morton, Jennifer P.

“…CXCR2 has been suggested to have both tumor-promoting and tumor-suppressive properties. Here we show that CXCR2 signaling is upregulated in human pancreatic…”
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Effects of clinical mastitis caused by gram-positive and gram-negative bacteria and other organisms on the probability of conception in New York State Holstein dairy cows by Hertl, J A, Gröhn, Y T, Leach, J D G, Bar, D, Bennett, G J, González, R N, Rauch, B J, Welcome, F L, Tauer, L W, Schukken, Y H

“…The objective of this study was to estimate the effects of different types of clinical mastitis (CM) on the probability of conception in New York State…”
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reciprocal backcross monosomic analysis of the scab resistant spring wheat (Triticum aestivum L.) cultivar, 'Frontana' by Berzonsky, W.A, Gebhard, B.L, Gamotin, E, Leach, G.D, Ali, S

“…Fusarium head blight (FHB) reduces grain yield of spring wheat and results in deoxynivalenol (DON) production. The resistant spring wheat 'Frontana' could be…”
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RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome by Rooney, Nicholas, Mason, Susan M, McDonald, Laura, Däbritz, J Henry M, Campbell, Kirsteen J, Hedley, Ann, Howard, Steven, Athineos, Dimitris, Nixon, Colin, Clark, William, Leach, Joshua D G, Sansom, Owen J, Edwards, Joanne, Cameron, Ewan R, Blyth, Karen

“…The recurring association of specific genetic lesions with particular types of cancer is a fascinating and largely unexplained area of cancer biology. This is…”
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Registration of four synthetic hexaploid wheat germplasm lines with resistance to Fusarium head blight by Berzonsky, W.A, Hartel, K.D, Kianian, S.F, Leach, G.D

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Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features by Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D. G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., Sansom, Owen J.

“…The pro-tumourigenic role of epithelial TGFβ signalling in colorectal cancer (CRC) is controversial. Here, we identify a cohort of born to be bad early-stage…”
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Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features by Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D. G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., Sansom, Owen J.

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Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest by Dikovskaya, Dina, Cole, John J., Mason, Susan M., Nixon, Colin, Karim, Saadia A., McGarry, Lynn, Clark, William, Hewitt, Rachael N., Sammons, Morgan A., Zhu, Jiajun, Athineos, Dimitris, Leach, Joshua D.G., Marchesi, Francesco, van Tuyn, John, Tait, Stephen W., Brock, Claire, Morton, Jennifer P., Wu, Hong, Berger, Shelley L., Blyth, Karen, Adams, Peter D.

“…Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signaling. OIS is frequently…”
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Loss of Cxcr2 in Myeloid Cells Promotes Tumour Progression and T Cell Infiltration in Invasive Bladder Cancer by Ismail, Nur Faezah Binti, Foth, Mona, Yousef, Amal Rahil Elgaddafi, Cui, Ningxuan, Leach, Joshua D.G., Jamieson, Thomas, Karim, Saadia A., Salmond, Jonathan M., Morton, Jennifer P., Iwata, Tomoko

“…BACKGROUND: CXCR2 is a chemokine receptor expressed in myeloid cells, including neutrophils and macrophages. Pharmacological inhibition of CXCR2 has been shown…”
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Characterization of toxicity involving haemorrhage and cardiovascular failure, caused by parenteral administration of a soluble polyacrylate in the rat by Hicks, R, Satti, A K, Leach, G D, Naylor, I L

“…Adverse effects, involving a combination of hypotension and widespread haemorrhages, as well as evidence of vascullar and other tissue dissociation, associated…”
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The role of the sympathetic nervous system in the cardiovascular responses to angiotensin in the pithed rat by FINCH, L., LEACH, G. D. H.

“…1 Angiotensin (200–500 ng, intravenously) produced a biphasic pressor response accompanied by reflex bradycardia in rats anaesthetized with sodium…”
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effects of parthenogenesis on wheat embryo formation and haploid production with and without maize pollination by Berzonsky, William A, Kleven, Sara L, Leach, Gene D

“…Doubled haploid (DH) lines are important in wheat (Triticum aestivum L.) breeding, and haploids produced via maize pollination precede DH line development…”
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Dopamine-beta-hydroxylase release following acute selective sympathetic nerve stimulation of the heart, spleen and mesentery by Algate, D R, Leach, G D

“…In increase in the concentration of dopamine-beta-hydroxylase (DBH) in the blood perfusates of the heart, spleen and mesentery of pithed rats was detected…”
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The effects of phospholipase C on excitation-contraction coupling mechanisms in smooth muscle by Lodge, S, Leach, G D

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Hypertension: its effect on the stimulated release of dopamine-beta-hydroxylase in the rat by Algate, D R, Leach, G D

“…Plasma dopamine-beta-hydroxylase (DBH) concentrations have been postulated as providing an index of sympathetic nerve activity. Using a microspectrophotometric…”
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Effects of 6-hydroxydopamine on the perfused rat mesentery preparation by Finch, L, Leach, G D

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The electrically stimulated ileum of the guinea-pig for measuring acetylcholine antagonism at different sites by Leach, G D

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The effect of temperature on end-plate depolarization of the rat diaphragm produced by suxamethonium and acetylcholine by Harris, J B, Leach, G D

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