Search Results - "Leach, CA"

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance by Chauhan, Dharminder, Tian, Ze, Nicholson, Benjamin, Kumar, K.G. Suresh, Zhou, Bin, Carrasco, Ruben, McDermott, Jeffrey L., Leach, Craig A., Fulcinniti, Mariaterresa, Kodrasov, Matthew P., Weinstock, Joseph, Kingsbury, William D., Hideshima, Teru, Shah, Parantu K., Minvielle, Stephane, Altun, Mikael, Kessler, Benedikt M., Orlowski, Robert, Richardson, Paul, Munshi, Nikhil, Anderson, Kenneth C.

“…Bortezomib therapy has proven successful for the treatment of relapsed/refractory, relapsed, and newly diagnosed multiple myeloma (MM); however, dose-limiting…”
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Ubiquitin/SUMO modification of PCNA promotes replication fork progression in Xenopus laevis egg extracts by Leach, Craig A, Michael, W. Matthew

“…The homotrimeric DNA replication protein proliferating cell nuclear antigen (PCNA) is regulated by both ubiquitylation and sumoylation. We study the appearance…”
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Activation of Aurora-A Kinase by Protein Phosphatase Inhibitor-2, a Bifunctional Signaling Protein by Satinover, David L., Leach, Craig A., Stukenberg, P. Todd, Brautigan, David L., Ruderman, Joan V.

“…Aurora-A kinase is necessary for centrosome maturation, for assembly and maintenance of a bipolar spindle, and for proper chromosome segregation during cell…”
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GSK1562590, a slowly dissociating urotensin‐II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo by Behm, DJ, Aiyar, NV, Olzinski, AR, McAtee, JJ, Hilfiker, MA, Dodson, JW, Dowdell, SE, Wang, GZ, Goodman, KB, Sehon, CA, Harpel, MR, Willette, RN, Neeb, MJ, Leach, CA, Douglas, SA

“…BACKGROUND AND PURPOSE Recently identified antagonists of the urotensin–II (U‐II) receptor (UT) are of limited utility for investigating the…”
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Hypernickelemia following coronary arteriography, caused by nickel in the radiographic contrast medium by Leach, Jr, C A, Sunderman, Jr, F W

“…Meglumine diatrizoate ("Renografin-76", a radiographic contrast medium) contains sufficient nickel to cause hypernickelemia in patients after coronary…”
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Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones by Boyd, Helen F, Fell, Stephen C M, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Macphee, Colin H, Milliner, Kevin J, Pinto, Ivan L, Rawlings, D Anthony, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Theobald, Colin J, Whittaker, Caroline M

“…A series of 1-(biphenylmethylamidoalkyl)-pyrimidones has been designed as nanomolar inhibitors of recombinant lipoprotein-associated phospholipase A(2) with…”
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Spectroscopy and quantum mechanics of the hydrogen molecular cation: a test of molecular quantum mechanics by Leach, C A, Moss, R E

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1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A(2) by Bloomer, J C, Boyd, H F, Hickey, D M, Ife, R J, Leach, C A, Macphee, C H, Milliner, K J, Pinto, I L, Rawlings, D A, Smith, S A, Stansfield, I G, Stanway, S J, Taylor, M A, Theobald, C J, Whittaker, C M

“…The lipophilic 1-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, inhibitors of recombinant lipoprotein-associated phospholipase A(2), has been…”
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Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 5. Substituted 2,4-Diaminoquinazolines and Thienopyrimidines by Ife, Robert J, Brown, Thomas H, Blurton, Peter, Keeling, David J, Leach, Colin A, Meeson, Malcolm L, Parsons, Michael E, Theobald, Colin J

“…Quinazolines bearing a secondary 4-(arylamino) substituent demonstrate an SAR for inhibition of the gastric (H+/K+)-ATPase different from the previously…”
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(H+, K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate by Kohl, Bernhard, Sturm, Ernst, Senn-Bilfinger, Joerg, Simon, W. Alexander, Krueger, Uwe, Schaefer, Hartmann, Rainer, Georg, Figala, Volker, Klemm, Kurt

“…[(Pyridylmethyl)sulfinyl]benzimidazoles 1 (PSBs) are a class of highly potent antisecretory (H+,K+)-ATPase inhibitors which need to be activated by acid to…”
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Electric field dissociation of H+ 2: close-coupled scattering calculations by LEACH, CHRISTINE A., CHILD, M. S., MANOLOPOULOS, D. E.

“…Close-coupling scattering calculations have been carried out to predict the magnitude of electric fields required to dissociate specific vibration-rotation…”
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Transgenic mice for the preparation of puromycin-resistant primary embryonic fibroblast feeder layers for embryonic stem cell selection by Linnell, E R, Lerner, C P, Johnson, K A, Leach, C A, Ulrich, T R, Rafferty, W C, Simpson, E M

“…Transgenesis in the mouse has progressed from single gene methods to multiple targeting strategies, driving the search for additional drug selection markers…”
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Reversible inhibitors of the gastric (H+/K+)-ATPase. 2. 1-Arylpyrrolo[3,2-c]quinolines: effect of the 4-substituent by Leach, Colin A, Brown, Thomas H, Ife, Robert J, Keeling, David J, Laing, Shiona M, Parsons, Michael E, Price, Carolyn A, Wiggall, Kenneth J

“…Further work on compounds 1 has identified the 4-position as a site where substantial modifications are tolerated, leading to analogues which are more potent…”
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Reversible inhibitors of the gastric (H+/K+)-ATPase. 3. 3-Substituted-4-(phenylamino)quinolines by Ife, Robert J, Brown, Thomas H, Keeling, David J, Leach, Colin A, Meeson, Malcolm L, Parsons, Michael E, Reavill, David R, Theobald, Colin J, Wiggall, Kenneth J

“…Previously, gastric (H+/K+)-ATPase inhibitors such as 2 have been prepared as analogues of 1a on the presumption that the 3-carbethoxy substituent plays a key…”
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Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 4. Identification of an Inhibitor with an Intermediate Duration of Action by Leach, Colin A, Brown, Thomas H, Ife, Robert J, Keeling, David J, Parsons, Michael E, Theobald, Colin J, Wiggall, Kenneth J

“…3-Acyl-4-(arylamino)quinolines were previously identified as gastric (H+/K+)-ATPase inhibitors, and clinical efficacy has been demonstrated for compound 3…”
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Reversible inhibitors of the gastric (H+/K+)-ATPase. 1. 1-Aryl-4-methylpyrrolo[3,2-c]quinolines as conformationally restrained analogs of 4-(arylamino)quinolines by Brown, Thomas H, Ife, Robert J, Keeling, David J, Laing, Shiona M, Leach, Colin A, Parsons, Michael E, Price, Carolyn A, Reavill, David R, Wiggall, Kenneth J

“…The 4-(arylamino)quinoline 4, previously described as an antiulcer compound, is shown to be an inhibitor of the gastric (H+/K+)-ATPase. It is postulated that…”
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Reversible inhibitors of the gastric (H super(+)/K super(+))-ATPase. 5. Substituted 2,4-diaminoquinazolines and thienopyrimidines by Ife, R J, Brown, TH, Blurton, P, Keeling, D J, Leach, CA, Meeson, M L, Parsons, ME, Theobald, C J

“…Quinazolines bearing a secondary 4-(arylamino) substituent demonstrate an SAR for inhibition of the gastric (H super(+)/K super(+))-ATPase different from the…”
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4-(2-PYRTOYL)-5-phenylthiazoles as novel non-bicyclic reversible inhibitors of the gastric H +/K +-atpase by Ife, R.J., Leach, C.A., Pope, A.J., Theobald, C.J.

“…4-(2-Pyridyl)-5-phenylthiazoles, 3 (X = S), are shown to be reversible, K +-competitive gastric H +/K +-ATPase inhibitors. It is suggested that a hydrogen-bond…”
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A Raman microprobe study of a magnesia partially stabilized zirconia fracture surface by LEACH, C. A

“…Raman microprobe analysis has been used to determine the extent of phase transformation on the fracture surface of a magnesia partially stabilized zirconia…”
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(H+-K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 2. The reaction cascade induced by treatment with acids. Formation of 5H-pyrido[1',2':4,5][1,2,4]thiadiazino[2,3-a]benzimidazol-13-ium salts and their reactions with thiols by Senn-Bilfinger, Joerg, Krueger, Uwe, Sturm, Ernst, Figala, Volker, Klemm, Kurt, Kohl, Bernhard, Rainer, Georg, Schaefer, Hartmann, Blake, Timothy J

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