Search Results - "Leach, C"

Development of the Horse Grimace Scale (HGS) as a pain assessment tool in horses undergoing routine castration by Dalla Costa, Emanuela, Minero, Michela, Lebelt, Dirk, Stucke, Diana, Canali, Elisabetta, Leach, Matthew C

“…The assessment of pain is critical for the welfare of horses, in particular when pain is induced by common management procedures such as castration. Existing…”
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The Mouse Grimace Scale: A Clinically Useful Tool? by Miller, Amy L, Leach, Matthew C

“…Medical research has a heavy and continuing demand for rodent models across a range of disciplines. Behavioural assessment of pain in such models is highly…”
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Can grimace scales estimate the pain status in horses and mice? A statistical approach to identify a classifier by Dalla Costa, Emanuela, Pascuzzo, Riccardo, Leach, Matthew C, Dai, Francesca, Lebelt, Dirk, Vantini, Simone, Minero, Michela

“…Pain recognition is fundamental for safeguarding animal welfare. Facial expressions have been investigated in several species and grimace scales have been…”
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In situ high temperature X-ray photoelectron spectroscopy study of barium strontium iron cobalt oxide by Norman, C., Leach, C.

“…► X-ray photoelectron spectroscopy study of Ba 0.5Sr 0.5Co 0.8Fe 0.2O 3− δ membrane. ► In situ heating to measure effect of temperature on surface chemistry. ►…”
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Evaluation of EMLA cream for preventing pain during tattooing of rabbits: changes in physiological, behavioural and facial expression responses by Keating, Stephanie C J, Thomas, Aurelie A, Flecknell, Paul A, Leach, Matthew C

“…Ear tattooing is a routine procedure performed on laboratory, commercial and companion rabbits for the purpose of identification. Although this procedure is…”
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Handling method alters the hedonic value of reward in laboratory mice by Clarkson, Jasmine M., Dwyer, Dominic M., Flecknell, Paul A., Leach, Matthew C., Rowe, Candy

“…Mice are the most widely used model species for drug discovery and scientific research. Consequently, it is important to refine laboratory procedures and…”
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The composition and initial evaluation of a grimace scale in ferrets after surgical implantation of a telemetry probe by Reijgwart, Marsinah L, Schoemaker, Nico J, Pascuzzo, Riccardo, Leach, Matthew C, Stodel, Melanie, de Nies, Loes, Hendriksen, Coenraad F M, van der Meer, Miriam, Vinke, Claudia M, van Zeeland, Yvonne R A

“…Reliable recognition of pain is difficult in ferrets as many currently available parameters are non-specific, inconsistent and/or impractical. Grimace scales…”
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Operando neutron diffraction reveals mechanisms for controlled strain evolution in 3D printing by Plotkowski, A., Saleeby, K., Fancher, C. M., Haley, J., Madireddy, G., An, K., Kannan, R., Feldhausen, T., Lee, Y., Yu, D., Leach, C., Vaughan, J., Babu, S. S.

“…Residual stresses affect the performance and reliability of most manufactured goods and are prevalent in casting, welding, and additive manufacturing (AM, 3D…”
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Substituting a pasture-based diet with plantain (Plantago lanceolata) reduces nitrogen excreted in urine from dairy cows in late lactation by Minnée, E.M.K., Leach, C.M.T., Dalley, D.E.

“…•Urine N concentration decreases non-linearly as percentage of plantain in the diet of dairy cows increases.•Dietary N is partitioned away from urine to into…”
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Postoperative pain behaviours in rabbits following orthopaedic surgery and effect of observer presence by Pinho, Renata Haddad, Leach, Matthew C, Minto, Bruno Watanabe, Rocha, Fabiana Del Lama, Luna, Stelio Pacca Loureiro

“…Rabbits are widely used in studies focusing on pain. However, pain is undertreated in this species and one possible factor to explain this is the lack of…”
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The assessment of post-vasectomy pain in mice using behaviour and the Mouse Grimace Scale by Leach, Matthew C, Klaus, Kristel, Miller, Amy L, Scotto di Perrotolo, Maud, Sotocinal, Susana G, Flecknell, Paul A

“…Current behaviour-based pain assessments for laboratory rodents have significant limitations. Assessment of facial expression changes, as a novel means of pain…”
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Validation of the rabbit pain behaviour scale (RPBS) to assess acute postoperative pain in rabbits (Oryctolagus cuniculus) by Haddad Pinho, Renata, Luna, Stelio Pacca Loureiro, Esteves Trindade, Pedro Henrique, Augusto Justo, André, Santilli Cima, Daniela, Werneck Fonseca, Mariana, Watanabe Minto, Bruno, Del Lama Rocha, Fabiana, Miller, Amy, Flecknell, Paul, Leach, Matthew C

“…Considering the widespread use of rabbits in research that potentially causes pain and discomfort and the limited number of pain assessment validated tools in…”
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A RNA-DNA Hybrid Aptamer for Nanoparticle-Based Prostate Tumor Targeted Drug Delivery by Leach, John C, Wang, Andrew, Ye, Kaiming, Jin, Sha

“…The side effects of radio- and chemo-therapy pose long-term challenges on a cancer patient's health. It is, therefore, highly desirable to develop more…”
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Potent preclinical activity of FLT3-directed chimeric antigen receptor T-cell immunotherapy against FLT3 - mutant acute myeloid leukemia and KMT2A -rearranged acute lymphoblastic leukemia by Niswander, Lisa M, Graff, Zachary T, Chien, Christopher D, Chukinas, John A, Meadows, Christina A, Leach, Lillie C, Loftus, Joseph P, Kohler, M Eric, Tasian, Sarah K, Fry, Terry J

“…Chimeric antigen receptor (CAR) T-cell immunotherapies targeting CD19 or CD22 induce remissions in the majority of patients with relapsed/refractory B-cell…”
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Prospects of Controlled Auto-Ignition Based Thermal Propulsion Units for Modern Gasoline Vehicles by Bajwa, Abdullah U., Leach, Felix C. P., Davy, Martin H.

“…Gasoline engines employing the spatially distributed auto-ignition combustion mode, known as controlled auto-ignition (CAI), are a prospective technology for…”
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Comparison of photoelectrochemical properties of TiO2 Nanotubes and sol-gel by Regonini, D., Chen, G., Leach, C., Clemens, F.J.

“…The photoelectrochemical properties of anodized TiO2 Nanotubes (NTs) grown using low (2wt.%) and high (12wt.%) water content and of nanostructured TiO2…”
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The identification of effective welfare indicators for laboratory-housed macaques using a Delphi consultation process by Truelove, Melissa A., Martin, Jessica E., Langford, Fritha M., Leach, Matthew C.

“…Despite the importance for both animal welfare and scientific integrity of effective welfare assessment in non-human primates, there has been little or no…”
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The perspectives of UK personnel towards current killing practices for laboratory rodents by Clarkson, Jasmine M., Leach, Matthew C., McKeegan, Dorothy E. F., Martin, Jessica E.

“…Rodents are the predominant species used for scientific research and must be humanely killed upon completion of the work. In the UK this is regulated by…”
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Characterization of short- and long-term mechanical sensitisation following surgical tail amputation in pigs by Di Giminiani, Pierpaolo, Edwards, Sandra A., Malcolm, Emma M., Leach, Matthew C., Herskin, Mette S., Sandercock, Dale A.

“…Commercial pigs are frequently exposed to tail mutilations in the form of preventive husbandry procedures (tail docking) or as a result of abnormal behaviour…”
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Diurnal rhythms in cholinergic modulation of rapid dopamine signals and associative learning in the striatum by Stowe, Taylor A., Pitts, Elizabeth G., Leach, Amy C., Iacino, Melody C., Niere, Farr, Graul, Benjamin, Raab-Graham, Kimberly F., Yorgason, Jordan T., Ferris, Mark J.

“…Dysregulation of biological rhythms plays a role in a wide range of psychiatric disorders. We report mechanistic insights into the rhythms of rapid dopamine…”
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