Search Results - "Lea, T"

The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer’s disease by Matchett, Billie J., Grinberg, Lea T., Theofilas, Panos, Murray, Melissa E.

“…Alzheimer’s disease (AD) is neuropathologically characterized by the intracellular accumulation of hyperphosphorylated tau and the extracellular deposition of…”
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Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease by Leng, Kun, Li, Emmy, Eser, Rana, Piergies, Antonia, Sit, Rene, Tan, Michelle, Neff, Norma, Li, Song Hua, Rodriguez, Roberta Diehl, Suemoto, Claudia Kimie, Leite, Renata Elaine Paraizo, Ehrenberg, Alexander J., Pasqualucci, Carlos A., Seeley, William W., Spina, Salvatore, Heinsen, Helmut, Grinberg, Lea T., Kampmann, Martin

“…Alzheimer’s disease (AD) is characterized by the selective vulnerability of specific neuronal populations, the molecular signatures of which are largely…”
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Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies by Sanders, David W., Kaufman, Sarah K., DeVos, Sarah L., Sharma, Apurwa M., Mirbaha, Hilda, Li, Aimin, Barker, Scarlett J., Foley, Alex C., Thorpe, Julian R., Serpell, Louise C., Miller, Timothy M., Grinberg, Lea T., Seeley, William W., Diamond, Marc I.

“…Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique…”
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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy by Shi, Yang, Yamada, Kaoru, Liddelow, Shane Antony, Smith, Scott T., Zhao, Lingzhi, Luo, Wenjie, Tsai, Richard M., Spina, Salvatore, Grinberg, Lea T., Rojas, Julio C., Gallardo, Gilbert, Wang, Kairuo, Roh, Joseph, Robinson, Grace, Finn, Mary Beth, Jiang, Hong, Sullivan, Patrick M., Baufeld, Caroline, Wood, Michael W., Sutphen, Courtney, McCue, Lena, Xiong, Chengjie, Del-Aguila, Jorge L., Morris, John C., Cruchaga, Carlos, Fagan, Anne M., Miller, Bruce L., Boxer, Adam L., Seeley, William W., Butovsky, Oleg, Barres, Ben A., Paul, Steven M., Holtzman, David M.

“…ApoE4 exacerbates tau pathogenesis, neuroinflammation and tau-mediated neurodegeneration independently of brain amyloid-β pathology, and exerts a ‘toxic’ gain…”
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Is Alzheimer disease a disease? by Korczyn, Amos D., Grinberg, Lea T.

“…Dementia, a prevalent condition among older individuals, has profound societal implications. Extensive research has resulted in no cure for what is perceived…”
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Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy by Wang, Chao, Fan, Li, Khawaja, Rabia R., Liu, Bangyan, Zhan, Lihong, Kodama, Lay, Chin, Marcus, Li, Yaqiao, Le, David, Zhou, Yungui, Condello, Carlo, Grinberg, Lea T., Seeley, William W., Miller, Bruce L., Mok, Sue-Ann, Gestwicki, Jason E., Cuervo, Ana Maria, Luo, Wenjie, Gan, Li

“…Activation of microglia is a prominent pathological feature in tauopathies, including Alzheimer’s disease. How microglia activation contributes to tau toxicity…”
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Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism by Prusiner, Stanley B., Woerman, Amanda L., Mordes, Daniel A., Watts, Joel C., Rampersaud, Ryan, Berry, David B., Patel, Smita, Oehler, Abby, Lowe, Jennifer K., Kravitz, Stephanie N., Geschwind, Daniel H., Glidden, David V., Halliday, Glenda M., Middleton, Lefkos T., Gentleman, Steve M., Grinberg, Lea T., Giles, Kurt

“…Prions are proteins that adopt alternative conformations that become self-propagating; the PrPScprion causes the rare human disorder Creutzfeldt–Jakob disease…”
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Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease by Spina, Salvatore, La Joie, Renaud, Petersen, Cathrine, Nolan, Amber L, Cuevas, Deion, Cosme, Celica, Hepker, Mackenzie, Hwang, Ji-Hye, Miller, Zachary A, Huang, Eric J, Karydas, Anna M, Grant, Harli, Boxer, Adam L, Gorno-Tempini, Maria Luisa, Rosen, Howard J, Kramer, Joel H, Miller, Bruce L, Seeley, William W, Rabinovici, Gil D, Grinberg, Lea T

“…Copathologies play an important role in the expression of the AD clinical phenotype and may influence treatment efficacy. Early-onset AD (EOAD), defined as…”
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Typical and atypical pathology in primary progressive aphasia variants by Spinelli, Edoardo G., Mandelli, Maria Luisa, Miller, Zachary A., Santos‐Santos, Miguel A, Wilson, Stephen M., Agosta, Federica, Grinberg, Lea T., Huang, Eric J., Trojanowski, John Q., Meyer, Marita, Henry, Maya L., Comi, Giancarlo, Rabinovici, Gil, Rosen, Howard J., Filippi, Massimo, Miller, Bruce L., Seeley, William W., Gorno‐Tempini, Maria Luisa

“…Objective To characterize in vivo signatures of pathological diagnosis in a large cohort of patients with primary progressive aphasia (PPA) variants defined by…”
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Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment by Grothe, Michel J, Heinsen, Helmut, Amaro, Jr, Edson, Grinberg, Lea T, Teipel, Stefan J

“…Degeneration of basal forebrain (BF) cholinergic nuclei is associated with cognitive decline, and this effect is believed to be mediated by neuronal…”
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Tau-driven degeneration of sleep- and wake-regulating neurons in Alzheimer’s disease by Lew, Caroline H., Petersen, Cathrine, Neylan, Thomas C., Grinberg, Lea T.

“…Disturbances of the sleep/wake cycle in Alzheimer's disease (AD) are common, frequently precede cognitive decline, and tend to worsen with disease progression…”
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SV2A PET imaging in human neurodegenerative diseases by Bavarsad, Mahsa Shanaki, Grinberg, Lea T

“…This manuscript presents a thorough review of synaptic vesicle glycoprotein 2A (SV2A) as a biomarker for synaptic integrity using Positron Emission Tomography…”
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Synchrony in the periphery: inter-subject correlation of physiological responses during live music concerts by Czepiel, Anna, Fink, Lauren K., Fink, Lea T., Wald-Fuhrmann, Melanie, Tröndle, Martin, Merrill, Julia

“…While there is an increasing shift in cognitive science to study perception of naturalistic stimuli, this study extends this goal to naturalistic contexts by…”
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18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases by Soleimani-Meigooni, David N, Iaccarino, Leonardo, La Joie, Renaud, Baker, Suzanne, Bourakova, Viktoriya, Boxer, Adam L, Edwards, Lauren, Eser, Rana, Gorno-Tempini, Maria-Luisa, Jagust, William J, Janabi, Mustafa, Kramer, Joel H, Lesman-Segev, Orit H, Mellinger, Taylor, Miller, Bruce L, Pham, Julie, Rosen, Howard J, Spina, Salvatore, Seeley, William W, Strom, Amelia, Grinberg, Lea T, Rabinovici, Gil D

“…Few studies have evaluated the relationship between in vivo18F-flortaucipir PET and post-mortem pathology. We sought to compare antemortem 18F-flortaucipir PET…”
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Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease by Wesseling, Hendrik, Mair, Waltraud, Kumar, Mukesh, Schlaffner, Christoph N., Tang, Shaojun, Beerepoot, Pieter, Fatou, Benoit, Guise, Amanda J., Cheng, Long, Takeda, Shuko, Muntel, Jan, Rotunno, Melissa S., Dujardin, Simon, Davies, Peter, Kosik, Kenneth S., Miller, Bruce L., Berretta, Sabina, Hedreen, John C., Grinberg, Lea T., Seeley, William W., Hyman, Bradley T., Steen, Hanno, Steen, Judith A.

“…To elucidate the role of Tau isoforms and post-translational modification (PTM) stoichiometry in Alzheimer’s disease (AD), we generated a high-resolution…”
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Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells by Woerman, Amanda L., Aoyagi, Atsushi, Patel, Smita, Kazmi, Sabeen A., Lobach, Iryna, Grinberg, Lea T., McKee, Ann C., Seeley, William W., Olson, Steven H., Prusiner, Stanley B.

“…Tau prions are thought to aggregate in the central nervous system, resulting in neurodegeneration. Among the tauopathies, Alzheimer’s disease (AD) is the most…”
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Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation by Villeneuve, Sylvia, Rabinovici, Gil D, Cohn-Sheehy, Brendan I, Madison, Cindee, Ayakta, Nagehan, Ghosh, Pia M, La Joie, Renaud, Arthur-Bentil, Samia Kate, Vogel, Jacob W, Marks, Shawn M, Lehmann, Manja, Rosen, Howard J, Reed, Bruce, Olichney, John, Boxer, Adam L, Miller, Bruce L, Borys, Ewa, Jin, Lee-Way, Huang, Eric J, Grinberg, Lea T, DeCarli, Charles, Seeley, William W, Jagust, William

“…Amyloid-β, a hallmark of Alzheimer's disease, begins accumulating up to two decades before the onset of dementia, and can be detected in vivo applying…”
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Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration by Mattsson-Carlgren, Niklas, Grinberg, Lea T., Boxer, Adam, Ossenkoppele, Rik, Jonsson, Magnus, Seeley, William, Ehrenberg, Alexander, Spina, Salvatore, Janelidze, Shorena, Rojas-Martinex, Julio, Rosen, Howard, La Joie, Renaud, Lesman-Segev, Orit, Iaccarino, Leonardo, Kollmorgen, Gwendlyn, Ljubenkov, Peter, Eichenlaub, Udo, Gorno-Tempini, Maria Luisa, Miller, Bruce, Hansson, Oskar, Rabinovici, Gil Dan

“…To determine how fully automated Elecsys CSF immunoassays for β-amyloid (Aβ) and tau biomarkers and an ultrasensitive Simoa assay for neurofilament light chain…”
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The role of co-neurotransmitters in sleep and wake regulation by Oh, Jun, Petersen, Cathrine, Walsh, Christine M., Bittencourt, Jackson C., Neylan, Thomas C., Grinberg, Lea T.

“…Sleep and wakefulness control in the mammalian brain requires the coordination of various discrete interconnected neurons. According to the most conventional…”
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Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease by Illán-Gala, Ignacio, Lleo, Alberto, Karydas, Anna, Staffaroni, Adam M., Zetterberg, Henrik, Sivasankaran, Rajeev, Grinberg, Lea T., Spina, Salvatore, Kramer, Joel H., Ramos, Eliana M., Coppola, Giovanni, La Joie, Renaud, Rabinovici, Gil D., Perry, David C., Gorno-Tempini, Maria Luisa, Seeley, William W., Miller, Bruce L., Rosen, Howard J., Blennow, Kaj, Boxer, Adam L., Rojas, Julio C.

“…To test the hypothesis that plasma total tau (t-tau) and neurofilament light chain (NfL) concentrations may have a differential role in the study of…”
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