Search Results - "LeServe, Danielle S"
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Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer’s disease mouse models
Published in Nature communications (08-05-2024)“…The gut microbiota and microglia play critical roles in Alzheimer’s disease (AD), and elevated Bacteroides is correlated with cerebrospinal fluid amyloid-β…”
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Gamma-delta T cells modulate the microbiota and fecal micro-RNAs to maintain mucosal tolerance
Published in Microbiome (23-02-2023)“…Gamma-delta (γδ) T cells are a major cell population in the intestinal mucosa and are key mediators of mucosal tolerance and microbiota composition. Little is…”
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Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease
Published in Proceedings of the National Academy of Sciences - PNAS (12-09-2023)“…Emerging evidence suggests that dysregulation of neuroinflammation, particularly that orchestrated by microglia, plays a significant role in the pathogenesis…”
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Gamma-delta T cells suppress microbial metabolites that activate striatal neurons and induce repetitive/compulsive behavior in mice
Published in Brain, behavior, and immunity (01-03-2024)“…•γδ T cells regulate the gut microbiota.•In the absence of γδ T cells, mice develop a microbial dysbiosis with the growth of microbes involved in the…”
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High-salt diet induces microbiome dysregulation, neuroinflammation and anxiety in the chronic period after mild repetitive closed head injury in adolescent mice
Published in Brain communications (2024)“…Abstract The associations between human concussions and subsequent sequelae of chronic neuropsychiatric and cardiovascular diseases such as hypertension have…”
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