Search Results - "LeSauteur, L."

Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides by Beltinger, C, Saragovi, H U, Smith, R M, LeSauteur, L, Shah, N, DeDionisio, L, Christensen, L, Raible, A, Jarett, L, Gewirtz, A M

“…An enhanced appreciation of uptake mechanisms and intracellular trafficking of phosphorothioate modified oligodeoxynucleotides (P-ODN) might facilitate the use…”
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NMR structural studies of human cystatin C dimers and monomers by Ekiel, I., Abrahamson, M., Fulton, D.B., Lindahl, P., Storer, A.C., Levadoux, W., Lafrance, M., Labelle, S., Pomerleau, Y., Groleau, D., LeSauteur, L., Gehring, K.

“…Human cystatin C undergoes dimerization before unfolding. Dimerization leads to a complete loss of its activity as a cysteine proteinase inhibitor. A similar…”
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Monoclonal antibody to human trk-A: diagnostic and therapeutic potential in neuroblastoma by Kramer, K, Gerald, W, LeSauteur, L, Saragovi, H.U, Cheung, N.-K.V

“…5C3 is a murine IgG 1 antibody specific for the nerve growth factor (NGF) docking site of the human p140 trk-A receptor, with no cross-reactivity with human…”
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Prognostic value of TrkA protein detection by monoclonal antibody 5C3 in neuroblastoma by KRAMER, K, GERALD, W, LESAUTEUR, L, SARAGOVI, H. U, CHEUNG, N.-K. V

“…The effects of nerve growth factor, a neurotrophin mediating growth and differentiation of neural crest-derived cells, are mediated by the receptor TrkA. TrkA…”
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TrkA Induces Apoptosis of Neuroblastoma Cells and Does So via a p53-dependent Mechanism[boxs] by Lavoie, Jean-François, LeSauteur, Lynne, Kohn, Judi, Wong, Josee, Furtoss, Olivia, Thiele, Carol J., Miller, Freda D., Kaplan, David R.

“…Neuroblastoma (NB) is the most frequent solid extracranial tumor in children. Its clinical prognosis correlates with the expression of members of the Trk…”
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Small Peptide Mimics of Nerve Growth Factor Bind TrkA Receptors and Affect Biological Responses by LeSauteur, L, Wei, L, Gibbs, B F, Saragovi, H U

“…Small monomeric cyclic analogs that mimic the β-turn regions of nerve growth factor (NGF) were designed and synthesized. Potent competitive antagonists were…”
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Potent human p140-TrkA agonists derived from an anti-receptor monoclonal antibody by LeSauteur, L, Maliartchouk, S, Le Jeune, H, Quirion, R, Saragovi, HU

“…Monoclonal antibody (mAb) 5C3 directed against human p140 TrkA is a structural and functional mimic of nerve growth factor (NGF) and an artificial receptor…”
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Solution Structure and Internal Motion of a Bioactive Peptide Derived from Nerve Growth Factor by Beglova, Natalia, LeSauteur, Lynne, Ekiel, Irena, Saragovi, H. Uri, Gehring, Kalle

“…The conformation and internal dynamics of a bioactive cyclic peptide, N-acetyl-YCTDEKQCY, derived from the C-D loop of β-nerve growth factor (β-NGF) were…”
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Small molecule nerve growth factor analogs image receptors in vivo by LeSauteur, Lynne, Cheung, Nai-Kong V, Lisbona, Robert, Saragovl, H. Uri

“…The in vivo targeting efficacy of small molecule analogs of nerve growth factor (NGF) that bind the NGF receptor p140 TrkA was evaluated and compared with that…”
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Small peptide mimics of nerve growth factor bind TrkA receptors and affect biological responses by LeSauteur, Lynne, Wei, Ling, Gibbs, Bernard F., Saragovi, H. Uri

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