Search Results - "LeRoy, E C"

Criteria for the classification of early systemic sclerosis by E C LeRoy, T A Medsger, Jr

“…We propose criteria for the early diagnosis and classification of systemic sclerosis that reflect the vascular and serological advances of the last 2 decades…”
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Association between polymorphic variation in VDR and RXRA and circulating levels of vitamin D metabolites by Hibler, E.A., Jurutka, P.W., Egan, J.B., Hu, C., LeRoy, E.C., Martinez, M.E., Thompson, P.A., Jacobs, E.T.

“…The vitamin D metabolite 1,25(OH) 2D is the bioactive ligand of the vitamin D receptor (VDR). VDR forms a heterodimer with the retinoid X receptors (RXRs) that…”
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Systemic sclerosis. A vascular perspective by LeRoy, E C

“…The horizon is bright for SSc in a vascular context. Surrogate markers can now be routinely used in the management of the active patient; new cytokines, such…”
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A disease severity scale for systemic sclerosis: development and testing by Medsger, Jr, T A, Silman, A J, Steen, V D, Black, C M, Akesson, A, Bacon, P A, Harris, C A, Jablonska, S, Jayson, M I, Jimenez, S A, Krieg, T, Leroy, E C, Maddison, P J, Russell, M L, Schachter, R K, Wollheim, F A, Zacharaie, H

“…To develop and test a severity scale for individual organ involvements in systemic sclerosis (SSc, scleroderma). An international study group completed the…”
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Raynaud's phenomenon: a proposal for classification by LeRoy, E C, Medsger, Jr, T A

“…Major confusion exists with regard to the definition of patients with Raynaud's phenomenon; defining the patient and the phenomenon are reasonably…”
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A brief overview of the pathogenesis of scleroderma (systemic sclerosis) by LeRoy, E C

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Scleroderma bronchoalveolar lavage fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of platelet-derived growth factor alpha-receptor by Ohba, T, McDonald, J K, Silver, R M, Strange, C, LeRoy, E C, Ludwicka, A

“…In addition to its procoagulant properties, the serine protease thrombin increases endothelial permeability, stimulates granulocyte adherence, and serves as a…”
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Autoimmunity and Vascular Involvement in Systemic Sclerosis (SSc) by Kahalefp, M. Bashar, Leroy, E. Carwile

“…Endothelial injury, obliterative microvascular lesions, and increased vascular wall thickness are present in all involved organs in scleroderma. The vascular…”
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A profibrotic polymorphism (of TGFβ1) in systemic sclerosis by Pandey, J P, LeRoy, E C

“…Possibly, particular alleles at these loci additively (or interactively) influence the quantitative (and possibly qualitative) expression of this cytokine…”
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Natural history of asymptomatic left ventricular systolic dysfunction in the community by WANG, Thomas J, EVANS, Jane C, BENJAMIN, Emelia J, LEVY, Daniel, LEROY, Elizabeth C, VASAN, Ramachandran S

“…Information is limited regarding the rates of progression to congestive heart failure (CHF) and death in individuals with asymptomatic left ventricular…”
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Interleukin-2 in scleroderma: correlation of serum level with extent of skin involvement and disease duration by Kahaleh, M B, LeRoy, E C

“…To assess whether interleukin-2 has a role in the pathogenesis of scleroderma. Observe serum effect on the in-vitro growth of an interleukin-2-dependent…”
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Evidence of activation of 2 herpesviruses, Epstein-Barr virus and cytomegalovirus, in systemic sclerosis and normal skins by Vaughan, J H, Shaw, P X, Nguyen, M D, Medsger, Jr, T A, Wright, T M, Metcalf, J S, Leroy, E C

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TGF-beta inhibition of endothelial cell proliferation: alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression by Takehara, K, LeRoy, E C, Grotendorst, G R

“…Transforming growth factor-beta (TGF-beta) inhibits the growth of endothelial cells derived from various sources, including human umbilical vein, bovine aorta,…”
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The 72-kilodalton IE-1 protein of human cytomegalovirus (HCMV) is a potent inducer of connective tissue growth factor (CTGF) in human dermal fibroblasts by MARKIEWICZ, M, SMITH, E. A, RUBINCHIK, S, DONG, J. Y, TROJANOWSKA, M, LEROY, E. C

“…Latent human cytomegalovirus (HCMV) infection has been implicated in diseases characterized by tissue remodeling. Because of recent evidence indicating the…”
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Quinolinic acid accumulation in injured spinal cord: time course, distribution, and species differences between rat and guinea pig by Blight, A R, Leroy, Jr, E C, Heyes, M P

“…Experimental compression injury of the spinal cord in guinea pigs results in delayed neurologic deficits that continue to increase in severity for several days…”
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A Possible Role for Transforming Growth Factor-β in Systemic Sclerosis by Smith, Edwin A., LeRoy, E. Carwile

“…The cause of systemic sclerosis remains unknown, but cellular and molecular mechanisms possibly responsible for the characteristic clinical manifestations of…”
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Fasciitis (not scleroderma) following prolonged exposure to an organic solvent (trichloroethylene) by Waller, P A, Clauw, D, Cupps, T, Metcalf, J S, Silver, R M, Leroy, E C

“…We describe 2 cases of diffuse fasciitis with eosinophilia (DFE) associated with prolonged exposure to the industrial solvent trichloroethylene (TCE). The…”
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Independent effects of platelet-derived growth factor isoforms on mitogen-activated protein kinase activation and mitogenesis in human dermal fibroblasts by LUBINUS, M, MEIER, K. E, SMITH, E. A, GAUSE, K. C, LEROY, E. C, TROJANOWSKA, M

“…Mitogen-activated protein kinase (MAPK) is activated in many cell types in response to growth factors during the G0-G1 transition in the cell cycle. We…”
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Diseases of the extracellular matrix by Krieg, T, LeRoy, E C

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Scleroderma and related conditions by Mitchell, H, Bolster, M B, LeRoy, E C

“…Systemic sclerosis is a generalized disorder characterized by fibrosis and microvascular injury in affected organs. Despite being recognized nearly 250 years…”
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