Search Results - "LeRoux, Andre"

Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity by Lucas-Hourani, Marianne, Dauzonne, Daniel, Jorda, Pierre, Cousin, Gaëlle, Lupan, Alexandru, Helynck, Olivier, Caignard, Grégory, Janvier, Geneviève, André-Leroux, Gwénaëlle, Khiar, Samira, Escriou, Nicolas, Desprès, Philippe, Jacob, Yves, Munier-Lehmann, Hélène, Tangy, Frédéric, Vidalain, Pierre-Olivier

“…Searching for stimulators of the innate antiviral response is an appealing approach to develop novel therapeutics against viral infections. Here, we…”
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Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase by Piton, Jérémie, Petrella, Stéphanie, Delarue, Marc, André-Leroux, Gwénaëlle, Jarlier, Vincent, Aubry, Alexandra, Mayer, Claudine

“…Mycobacterium tuberculosis DNA gyrase, an indispensable nanomachine involved in the regulation of DNA topology, is the only type II topoisomerase present in…”
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Expanding the Substrate Scope of Native Amine Dehydrogenases through In Silico Structural Exploration and Targeted Protein Engineering by Ducrot, Laurine, Bennett, Megan, André‐Leroux, Gwenaëlle, Elisée, Eddy, Marynberg, Sacha, Fossey‐Jouenne, Aurélie, Zaparucha, Anne, Grogan, Gideon, Vergne‐Vaxelaire, Carine

“…Native Amine Dehydrogenases (nat‐AmDHs) are NAD(P)H‐enzymes performing reductive amination, mainly active towards small aliphatic aldehydes and cyclic ketones,…”
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Identification of Novel Compounds Inhibiting the Kinase Activity of the CDK5/p25 Complex via Direct Binding to p25 by Jabeur, Riheb, Corbel, Caroline, Loyer, Pascal, Le Parc, Annabelle, Le Grand, Adélaide, Comte, Arnaud, Bach, Stéphane, André-Leroux, Gwenaëlle, Sire, Olivier, Ben Mansour, Hedi, Le Tilly, Véronique

“…Tamoxifen, the gold standard drug for endocrine therapy for breast cancer, modulates the phosphorylation status of the TAU protein in Alzheimer’s disease by…”
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Altered spinogenesis in iPSC-derived cortical neurons from patients with autism carrying de novo SHANK3 mutations by Gouder, Laura, Vitrac, Aline, Goubran-Botros, Hany, Danckaert, Anne, Tinevez, Jean-Yves, André-Leroux, Gwenaëlle, Atanasova, Ekaterina, Lemière, Nathalie, Biton, Anne, Leblond, Claire S., Poulet, Aurélie, Boland, Anne, Deleuze, Jean-François, Benchoua, Alexandra, Delorme, Richard, Bourgeron, Thomas, Cloëz-Tayarani, Isabelle

“…The synaptic protein SHANK3 encodes a multidomain scaffold protein expressed at the postsynaptic density of neuronal excitatory synapses. We previously…”
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The pro-inflammatory cytokine 14-3-3ε is a ligand of CD13 in cartilage by Nefla, Meriam, Sudre, Laure, Denat, Guillaume, Priam, Sabrina, Andre-Leroux, Gwenaëlle, Berenbaum, Francis, Jacques, Claire

“…Osteoarthritis is a whole-joint disease characterized by the progressive destruction of articular cartilage involving abnormal communication between…”
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The signaling peptide PapR is required for the activity of the quorum-sensor PlcRa in Bacillus thuringiensis by Huillet, Eugénie, Bridoux, Ludovic, Barboza, Isabelle, Lemy, Christelle, André-Leroux, Gwenaëlle, Lereclus, Didier

“…The transcriptional regulator PlcR, its cognate cell-cell signaling heptapeptide PapR , and the oligopeptide permease OppABCDF, required for PapR import, form…”
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CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders by Mercati, O, Huguet, G, Danckaert, A, André-Leroux, G, Maruani, A, Bellinzoni, M, Rolland, T, Gouder, L, Mathieu, A, Buratti, J, Amsellem, F, Benabou, M, Van-Gils, J, Beggiato, A, Konyukh, M, Bourgeois, J-P, Gazzellone, M J, Yuen, R K C, Walker, S, Delépine, M, Boland, A, Régnault, B, Francois, M, Van Den Abbeele, T, Mosca-Boidron, A L, Faivre, L, Shimoda, Y, Watanabe, K, Bonneau, D, Rastam, M, Leboyer, M, Scherer, S W, Gillberg, C, Delorme, R, Cloëz-Tayarani, I, Bourgeron, T

“…Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. Mutations of CNTN5…”
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Heme Uptake in Lactobacillus sakei Evidenced by a New Energy Coupling Factor (ECF)-Like Transport System by Verplaetse, Emilie, André-Leroux, Gwenaëlle, Duhutrel, Philippe, Coeuret, Gwendoline, Chaillou, Stéphane, Nielsen-Leroux, Christina, Champomier-Vergès, Marie-Christine

“…is a nonpathogenic lactic acid bacterium and a natural inhabitant of meat ecosystems. Although red meat is a heme-rich environment, does not need iron or heme…”
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Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis by Lisa, María-Natalia, Gil, Magdalena, André-Leroux, Gwénaëlle, Barilone, Nathalie, Durán, Rosario, Biondi, Ricardo M., Alzari, Pedro M.

“…Tuberculosis remains one of the world's deadliest human diseases, with a high prevalence of antibiotic-resistant Mycobacterium tuberculosis (Mtb) strains. A…”
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Structural Modeling of Cell Wall Peptidase CwpFM (EntFM) Reveals Distinct Intrinsically Disordered Extensions Specific to Pathogenic Bacillus cereus Strains by Tran, Seav-Ly, Cormontagne, Delphine, Vidic, Jasmina, André-Leroux, Gwenaëlle, Ramarao, Nalini

“…The emergence of as an opportunistic food-borne pathogen has intensified the need to distinguish strains of public health concern. The heterogeneity of the…”
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Intraspecific Diversity of Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii by Auger, Sandrine, Kropp, Camille, Borras-Nogues, Esther, Chanput, Wasaporn, Andre-Leroux, Gwenaelle, Gitton-Quent, Oscar, Benevides, Leandro, Breyner, Natalia, Azevedo, Vasco, Langella, Philippe, Chatel, Jean-Marc

“…The commensal bacterium has unique anti-inflammatory properties, at least some of which have been attributed to its production of MAM, the Microbial…”
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Mycobacterial Ser/Thr protein kinases and phosphatases: Physiological roles and therapeutic potential by Wehenkel, Annemarie, Bellinzoni, Marco, Graña, Martin, Duran, Rosario, Villarino, Andrea, Fernandez, Pablo, Andre-Leroux, Gwénaëlle, England, Patrick, Takiff, Howard, Cerveñansky, Carlos, Cole, Stewart T., Alzari, Pedro M.

“…Reversible protein phosphorylation is a major regulation mechanism of fundamental biological processes, not only in eukaryotes but also in bacteria. A growing…”
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Identification of Hanks-Type Kinase PknB-Specific Targets in the Streptococcus thermophilus Phosphoproteome by Henry, Céline, Haller, Lucia, Blein-Nicolas, Mélisande, Zivy, Michel, Canette, Alexis, Verbrugghe, Morgane, Mézange, Christine, Boulay, Mylène, Gardan, Rozenn, Samson, Samantha, Martin, Véronique, André-Leroux, Gwenaëlle, Monnet, Véronique

“…Protein phosphorylation especially on serine/threonine/tyrosine residues are frequent in many bacteria. This post-translational modification has been…”
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Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor by Lisa, María-Natalia, Cvirkaite-Krupovic, Virginija, Richet, Evelyne, André-Leroux, Gwenaëlle, Alzari, Pedro M, Haouz, Ahmed, Danot, Olivier

“…Abstract Upon triggering by their inducer, signal transduction ATPases with numerous domains (STANDs), initially in monomeric resting forms, multimerize into…”
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Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis by Le, Nguyen-Hung, Molle, Virginie, Eynard, Nathalie, Miras, Mathieu, Stella, Alexandre, Bardou, Fabienne, Galandrin, Ségolène, Guillet, Valérie, André-Leroux, Gwenaëlle, Bellinzoni, Marco, Alzari, Pedro, Mourey, Lionel, Burlet-Schiltz, Odile, Daffé, Mamadou, Marrakchi, Hedia

“…Mycolic acids are essential components of the mycobacterial cell envelope, and their biosynthetic pathway is a well known source of antituberculous drug…”
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The FHA-containing protein GarA acts as a phosphorylation-dependent molecular switch in mycobacterial signaling by England, Patrick, Wehenkel, Annemarie, Martins, Sonia, Hoos, Sylviane, André-Leroux, Gwénaëlle, Villarino, Andrea, Alzari, Pedro M.

“…Fork-head associated (FHA) domains are widely found in bacteria, but their cellular functions remain unclear. Here, we focus on Mycobacterium tuberculosis…”
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OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity by Segovia, Danilo, Haouz, Ahmed, Porley, Darío, Olivero, Natalia, Martínez, Mariano, Mariadassou, Mahendra, Berois, Mabel, André-Leroux, Gwenaëlle, Villarino, Andrea

“…Viral tyrosine phosphatases such as VH1 from Vaccinia and Variola virus are recognized as important effectors of host–pathogen interactions. While proteins…”
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14-3-3E, a new alarmin candidate, elicits a catabolic and proinflammatory effect involving innate immunity through TLR signaling in osteoarthritis by Millerand, M., Sudre, L., Nefla, M., Pene, F., Rousseau, C., Ravat, A., Pons, A., Andre-Leroux, G., Berenbaum, F., Jacques, C.

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Sugar beet ( Beta vulgaris) pectins are covalently cross-linked through diferulic bridges in the cell wall by Ralet, Marie-Christine, André-Leroux, Gwénaëlle, Quéméner, Bernard, Thibault, Jean-François

“…After acid and enzymatic degradation of sugar beet cell walls and fractionation of the solubilized products by hydrophobic interaction chromatography, three…”
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