Search Results - "LeProust, M."

Towards practical, high-capacity, low-maintenance information storage in synthesized DNA by Goldman, Nick, Bertone, Paul, Chen, Siyuan, Dessimoz, Christophe, LeProust, Emily M., Sipos, Botond, Birney, Ewan

“…An efficient and scalable strategy with robust error correction is reported for encoding a record amount of information (including images, text and audio…”
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Exonic Transcription Factor Binding Directs Codon Choice and Affects Protein Evolution by Stergachis, Andrew B., Haugen, Eric, Shafer, Anthony, Fu, Wenqing, LeProust, M., Akey, Joshua M., Stamatoyannopoulos, John A.

“…Genomes contain both a genetic code specifying amino acids and a regulatory code specifying transcription factor (TF) recognition sequences. We used genomic…”
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A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility by Bassik, Michael C., Kampmann, Martin, Lebbink, Robert Jan, Wang, Shuyi, Hein, Marco Y., Poser, Ina, Weibezahn, Jimena, Horlbeck, Max A., Chen, Siyuan, Mann, Matthias, Hyman, Anthony A., LeProust, Emily M., McManus, Michael T., Weissman, Jonathan S.

“…Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the…”
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Synthesis of high-quality libraries of long (150mer) oligonucleotides by a novel depurination controlled process by LeProust, Emily M, Peck, Bill J, Spirin, Konstantin, McCuen, Heather Brummel, Moore, Bridget, Namsaraev, Eugeni, Caruthers, Marvin H

“…We have achieved the ability to synthesize thousands of unique, long oligonucleotides (150mers) in fmol amounts using parallel synthesis of DNA on microarrays…”
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Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins by Bedbrook, Claire N., Rice, Austin J., Yang, Kevin K., Ding, Xiaozhe, Chen, Siyuan, LeProust, Emily M., Gradinaru, Viviana, Arnold, Frances H.

“…Integral membrane proteins (MPs) are key engineering targets due to their critical roles in regulating cell function. In engineering MPs, it can be extremely…”
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Utilizing Ethnic-Specific Differences in Minor Allele Frequency to Recategorize Reported Pathogenic Deafness Variants by Shearer, A. Eliot, Eppsteiner, Robert W., Booth, Kevin T., Ephraim, Sean S., Gurrola, José, Simpson, Allen, Black-Ziegelbein, E. Ann, Joshi, Swati, Ravi, Harini, Giuffre, Angelica C., Happe, Scott, Hildebrand, Michael S., Azaiez, Hela, Bayazit, Yildirim A., Erdal, Mehmet Emin, Lopez-Escamez, Jose A., Gazquez, Irene, Tamayo, Marta L., Gelvez, Nancy Y., Leal, Greizy Lopez, Jalas, Chaim, Ekstein, Josef, Yang, Tao, Usami, Shin-ichi, Kahrizi, Kimia, Bazazzadegan, Niloofar, Najmabadi, Hossein, Scheetz, Todd E., Braun, Terry A., Casavant, Thomas L., LeProust, Emily M., Smith, Richard J.H.

“…Ethnic-specific differences in minor allele frequency impact variant categorization for genetic screening of nonsyndromic hearing loss (NSHL) and other genetic…”
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Systematic Identification of Barriers to Human iPSC Generation by Qin, Han, Diaz, Aaron, Blouin, Laure, Lebbink, Robert Jan, Patena, Weronika, Tanbun, Priscilia, LeProust, Emily M., McManus, Michael T., Song, Jun S., Ramalho-Santos, Miguel

“…Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) holds enormous promise for regenerative medicine. To elucidate endogenous barriers…”
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A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation by van de Weijer, Michael L., Bassik, Michael C., Luteijn, Rutger D., Voorburg, Cornelia M., Lohuis, Mirjam A.M., Kremmer, Elisabeth, Hoeben, Rob C., LeProust, Emily M., Chen, Siyuan, Hoelen, Hanneke, Ressing, Maaike E., Patena, Weronika, Weissman, Jonathan S., McManus, Michael T., Wiertz, Emmanuel J.H.J., Lebbink, Robert Jan

“…Misfolded ER proteins are retrotranslocated into the cytosol for degradation via the ubiquitin–proteasome system. The human cytomegalovirus protein US11…”
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Temporal and Spatial Profile of Brain Diffusion-Weighted MRI After Cardiac Arrest by MLYNASH, Michael, CAMPBELL, Dennis M, LEPROUST, Emily M, FISCHBEIN, Nancy J, BAMMER, Roland, EYNGOM, Irina, HSIA, Amie W, MOSELEY, Michael, WIJMAN, Christine A. C

“…Diffusion-weighted magnetic resonance imaging of the brain is a promising technique to help predict functional outcome in comatose survivors of cardiac arrest…”
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Efficient and cost effective population resequencing by pooling and in-solution hybridization by Bansal, Vikas, Tewhey, Ryan, Leproust, Emily M, Schork, Nicholas J

“…High-throughput sequencing of targeted genomic loci in large populations is an effective approach for evaluating the contribution of rare variants to disease…”
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Enrichment of sequencing targets from the human genome by solution hybridization by Tewhey, Ryan, Nakano, Masakazu, Wang, Xiaoyun, Pabón-Peña, Carlos, Novak, Barbara, Giuffre, Angelica, Lin, Eric, Happe, Scott, Roberts, Doug N, LeProust, Emily M, Topol, Eric J, Harismendy, Olivier, Frazer, Kelly A

“…To exploit fully the potential of current sequencing technologies for population-based studies, one must enrich for loci from the human genome. Here we…”
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Pre-capture multiplexing improves efficiency and cost-effectiveness of targeted genomic enrichment by Shearer, A Eliot, Hildebrand, Michael S, Ravi, Harini, Joshi, Swati, Guiffre, Angelica C, Novak, Barbara, Happe, Scott, LeProust, Emily M, Smith, Richard J H

“…Targeted genomic enrichment (TGE) is a widely used method for isolating and enriching specific genomic regions prior to massively parallel sequencing. To make…”
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Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing by Jaffe, David B, Giannoukos, Georgia, Melnikov, Alexandre, Maguire, Jared, Fisher, Sheila, Fennell, Timothy, Gnirke, Andreas, Lander, Eric S, Brockman, William, Nusbaum, Chad, Rogov, Peter, Russ, Carsten, LeProust, Emily M, Gabriel, Stacey

“…Gnirke et al . present a bead-based method for capturing sequences of interest in the human genome for massively parallel sequencing. Using long, biotinylated…”
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Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips by Kosuri, Sriram, Eroshenko, Nikolai, LeProust, Emily M, Super, Michael, Way, Jeffrey, Li, Jin Billy, Church, George M

“…Development of cheap, high-throughput and reliable gene synthesis methods will broadly stimulate progress in biology and biotechnology. Currently, the reliance…”
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The DNA-encoded nucleosome organization of a eukaryotic genome by Tillo, Desiree, Moore, Irene K, LeProust, Emily M, Kaplan, Noam, Fondufe-Mittendorf, Yvonne, Widom, Jonathan, Lieb, Jason D, Hughes, Timothy R, Segal, Eran, Gossett, Andrea J, Field, Yair

“…Nucleosome organization is critical for gene regulation. In living cells this organization is determined by multiple factors, including the action of chromatin…”
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Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming by Hochedlinger, Konrad, Wang, Wei, Eggan, Kevin, LeProust, Emily M, Deng, Jie, Gore, Athurva, Gao, Yuan, Zhang, Kun, Xie, Bin, Shoemaker, Robert, Antosiewicz-Bourget, Jessica, Daley, George Q, Maherali, Nimet, Park, In-Hyun, Yu, Junying, Thomson, James, Egli, Dieter

“…Although technically feasible, whole-genome analysis of cytosine methylation using bisulfite sequencing remains prohibitively expensive for large eukaryotic…”
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Autoantigen discovery with a synthetic human peptidome by Solimini, Nicole L, Elledge, Stephen J, Larman, H Benjamin, Zhao, Zhenming, Laserson, Uri, Li, Mamie Z, Ciccia, Alberto, Gakidis, M Angelica Martinez, Church, George M, Kesari, Santosh, LeProust, Emily M

“…Larman et al . create a phage library containing >400,000 sequences encoding peptides that cover all open reading frames in the human genome. They then use…”
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Multiplex amplification of large sets of human exons by Church, George M, Shendure, Jay, Porreca, Gregory J, Zhang, Kun, Li, Jin Billy, Xie, Bin, Austin, Derek, Vassallo, Sara L, LeProust, Emily M, Peck, Bill J, Emig, Christopher J, Dahl, Fredrik, Gao, Yuan

“…A new generation of technologies is poised to reduce DNA sequencing costs by several orders of magnitude. But our ability to fully leverage the power of these…”
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Advancing genetic testing for deafness with genomic technology by Shearer, A Eliot, Black-Ziegelbein, E Ann, Hildebrand, Michael S, Eppsteiner, Robert W, Ravi, Harini, Joshi, Swati, Guiffre, Angelica C, Sloan, Christina M, Happe, Scott, Howard, Susanna D, Novak, Barbara, Deluca, Adam P, Taylor, Kyle R, Scheetz, Todd E, Braun, Terry A, Casavant, Thomas L, Kimberling, William J, Leproust, Emily M, Smith, Richard J H

“…Non-syndromic hearing loss (NSHL) is the most common sensory impairment in humans. Until recently its extreme genetic heterogeneity precluded comprehensive…”
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Evidence for the biogenesis of more than 1,000 novel human microRNAs by Friedländer, Marc R, Lizano, Esther, Houben, Anna J S, Bezdan, Daniela, Báñez-Coronel, Mónica, Kudla, Grzegorz, Mateu-Huertas, Elisabet, Kagerbauer, Birgit, González, Justo, Chen, Kevin C, LeProust, Emily M, Martí, Eulàlia, Estivill, Xavier

“…MicroRNAs (miRNAs) are established regulators of development, cell identity and disease. Although nearly two thousand human miRNA genes are known and new ones…”
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