Search Results - "LePage, Sophie"

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901 by Barrett, Stephen D., Bridges, Alexander J., Dudley, David T., Saltiel, Alan R., Fergus, James H., Flamme, Cathlin M., Delaney, Amy M., Kaufman, Michael, LePage, Sophie, Leopold, Wilbur R., Przybranowski, Sally A., Sebolt-Leopold, Judith, Van Becelaere, Keri, Doherty, Annette M., Kennedy, Robert M., Marston, Dan, Howard, W. Allen, Smith, Yvonne, Warmus, Joseph S., Tecle, Haile

“…A novel series of benzhydroxamic esters were identified as potent MEK inhibitors. Optimization of these esters produced the two clinical candidates CI-1040 and…”
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The kinetic properties of the carboxy terminal domain of the Bacillus licheniformis 749/I BlaR penicillin-receptor shed a new light on the derepression of (beta)-lactamase synthesis by Duval, Valerie, Swinnen, Marc, Lepage, Sophie, Brans, Alain

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The kinetic properties of the carboxy terminal domain of the Bacillus licheniformis 749/I BlaR penicillin‐receptor shed a new light on the derepression of β‐lactamase synthesis by Duval, Valérie, Swinnen, Marc, Lepage, Sophie, Brans, Alain, Granier, Benoît, Franssen, Christine, Frère, Jean‐Marie, Joris, Bernard

“…Summary To study the properties of the BlaR penicillin‐receptor involved in the induction of the Bacillus licheniformisβ‐lactamase, the water‐soluble carboxy…”
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When drug inactivation renders the target irrelevant to antibiotic resistance: a case story with β‐lactams by Lakaye, Bernard, Dubus, Alain, Lepage, Sophie, Groslambert, S., Frère, Jean‐Marie

“…By challenging the efficiency of some of our most useful antimicrobial weapons, bacterial antibiotic resistance is becoming an increasingly worrying clinical…”
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The penicillin sensory transducer, BlaR, involved in the inducibility of β‐lactamase synthesis in Bacillus licheniformis is embedded in the plasma membrane via a four‐α‐helix bundle by Hardt, Karin, Joris, Bernard, Lepage, Sophie, Brasseur, Robert, Lampen, J. Oliver, Frère, Jean‐Marie, Fink, Anthony L., Ghuysen, Jean‐Marie

“…Prediction studies, conformational analyses and membrane‐topology mapping lead to the conclusion that the penicillin sensory transducer, BlaR, involved in the…”
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Role of the conserved amino acids of the 'SDN' loop (Ser130, Asp131 and Asn132) in a class A beta-lactamase studied by site-directed mutagenesis by Jacob, F, Joris, B, Lepage, S, Dusart, J, Frère, J M

“…Ser130, Asp131 and Asn132 ('SDN') are highly conserved residues in class A beta-lactamases forming one wall of the active-site cavity. All three residues of…”
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When drug inactivation renders the target irrelevant to antibiotic resistance: A case story with (beta-lactams) by Lakaye, Bernard, Dubus, Alain, Lepage, Sophie, Groslambert, S, Frere, Jean-Marie

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Synthesis, purification and kinetic properties of fluorescein-labelled penicillins by LAKAYE, B, DAMBLON, C, JAMIN, M, GALLENI, M, LEPAGE, S, JORIS, B, MARCHAND-BRYNAERT, J, FRYDRYCH, C, FRERE, J.-M

“…The synthesis and properties of six fluorescein-labelled penicillins are reported. The two isomers of fluoresceyl-glycyl-6-amino-penicillanic acid are probably…”
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Dual multimodular class A penicillin-binding proteins in Mycobacterium leprae by Lepage, S, Dubois, P, Ghosh, T K, Joris, B, Mahapatra, S, Kundu, M, Basu, J, Chakrabarti, P, Cole, S T, Nguyen-Distèche, M, Ghuysen, J M

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Site-directed mutagenesis of the Actinomadura R39 DD-peptidase by Zhao, G H, Duez, C, Lepage, S, Forceille, C, Rhazi, N, Klein, D, Ghuysen, J M, Frère, J M

“…The role of various residues in the conserved structural elements of the Actinomadura R39 penicillin-sensitive dd-peptidase has been studied by site-directed…”
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A new, highly sensitive method for the detection and quantification of penicillin-binding proteins by GALLENI, M, LAKAYE, B, LEPAGE, S, JAMIN, M, THAMM, I, JORIS, B, FRERE, J.-M

“…A new method for the identification and quantification of penicillin-binding proteins is described which uses fluorescein-coupled penicillins. It allows the…”
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Kinetic properties of the Bacillus licheniformis penicillin-binding proteins by Lepage, S, Galleni, M, Lakaye, B, Joris, B, Thamm, I, Frere, J M

“…In the analysis of the interactions between beta-lactam antibiotics and their target enzymes, it is often difficult to estimate the kinetic properties of the…”
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Primary and predicted secondary structures of the Actinomadura R39 extracellular DD-peptidase, a penicillin-binding protein (PBP) related to the Escherichia coli PBP4 by GRANIER, B, DUEZ, C, LEPAGE, S, ENGLEBERT, S, DUSART, J, DIDEBERG, O, VAN BEEUMEN, J, FRERE, J.-M, GHYSEN, J.-M

“…As derived from gene cloning and sequencing, the 489-amino-acid DD-peptidase/penicillin-binding protein (PBP) produced by Actinomadura R39 has a primary…”
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Saturation of penicillin-binding protein 1 by beta-lactam antibiotics in growing cells of Bacillus licheniformis by Lepage, S, Lakaye, B, Galleni, M, Thamm, I, Crine, M, Groslambert, S, Frère, J M

“…With the help of a new highly sensitive method allowing the quantification of free penicillin-binding proteins (PBPs) and of an integrated mathematical model,…”
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Correction: Primary and predicted secondary structure of the actinomadura R39 extracellular DD-peptidase, a penicillin-binding protein (PBP) related to the escherichia coli PBP4 (Biochemical Journal(1992)282(786)) by Granier, Benoît, Duez, Colette, Lepage, Sophie, Englebert, Serge, Dusart, Jean, Dideberg, Otto, Van Baumeen, Jozef, Frère, Jean-Marie, Ghuysen, Jean-Marie

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Sponsor-CMO conflict management for clinical-phase biologics: sponsor-CMO conflicts are best prevented before they emerge. Selecting the right CMO and negotiating the terms of the master service agreement are the first steps torward that goal by Douette, Napierre, Ledent, Philippe, Lepage, Sophie, Bolon, Pascal

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Sponsor-CMO Conflict Management for Clinical-Phase Biologics by Douette, Napierre, Ledent, Philippe, Lepage, Sophie, Bolon, Pascal

“…The long-term nature of outsourcing biologics process development and GMP manufacturing over the course of clinical trial development can involve unforeseeable…”
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