Search Results - "LeFew, William R."

Evaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set by McConnell, Emma R., McClain, Maxine A., Ross, James, LeFew, William R., Shafer, Timothy J.

“…► Effects of 30 chemicals on neuronal activity were examined using 12 well MEA plates. ► Each chemical was tested at 50μM, or the highest soluble…”
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Multi-well microelectrode array recordings detect neuroactivity of ToxCast compounds by Valdivia, Pablo, Martin, Matt, LeFew, William R., Ross, James, Houck, Keith A., Shafer, Timothy J.

“…•92 Unique compounds from EPA's ToxCast library were tested for effects on neuronal networks using multi-well microelectrode array (mwMEA) plates.•The mwMEA…”
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In vitro screening of metal oxide nanoparticles for effects on neural function using cortical networks on microelectrode arrays by Strickland, Jenna D., Lefew, William R., Crooks, James, Hall, Diana, Ortenzio, Jayna NR, Dreher, Kevin, Shafer, Timothy J.

“…Nanoparticles (NPs) may translocate to the brain following inhalation or oral exposures, yet higher throughput methods to screen NPs for potential…”
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In Vitro Screening of Silver Nanoparticles and Ionic Silver using Neural Networks Yields Differential Effects on Spontaneous Activity and Pharmacological Responses by Strickland, Jenna D, LeFew, William R, Crooks, James, Hall, Diana, Ortenzio, Jayna N.R, Dreher, Kevin, Shafer, Timothy J

“…Abstract Silver nanoparticles (AgNPs) are used in a wide range of consumer and medical products because of their antimicrobial and antifungal properties, and…”
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Evaluation of microelectrode array data using Bayesian modeling as an approach to screening and prioritization for neurotoxicity testing by LeFew, William R., McConnell, Emma R., Crooks, James L., Shafer, Timothy J.

“…► MEA data from cortical cultures treated with 30 chemicals were analyzed using a Bayesian approach. ► The probability of chemical effect on firing rate…”
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Development of multi-route physiologically-based pharmacokinetic models for ethanol in the adult, pregnant, and neonatal rat by Martin, Sheppard A., McLanahan, Eva D., El-Masri, Hisham, LeFew, William R., Bushnell, Philip J., Boyes, William K., Choi, Kyoungju, Clewell, Harvey J., Campbell, Jerry L.

“…Biofuel blends of 10% ethanol (EtOH) and gasoline are common in the USA, and higher EtOH concentrations are being considered (15-85%). Currently, no…”
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Use of novel inhalation kinetic studies to refine physiologically-based pharmacokinetic models for ethanol in non-pregnant and pregnant rats by Martin, Sheppard A., Oshiro, Wendy M., Evansky, Paul A., Degn, Laura L., Ledbetter, Allen D., Ford, Jermaine, Todd Krantz, Q., LeFew, William R., Beasley, Tracey E., El-Masri, Hisham, McLanahan, Eva D., Boyes, William K., Bushnell, Philip J.

“…Abstract Ethanol (EtOH) exposure induces a variety of concentration-dependent neurological and developmental effects in the rat. Physiologically-based…”
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Accurate description of optical precursors and their relation to weak-field coherent optical transients by LeFew, William R., Venakides, Stephanos, Gauthier, Daniel J.

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Optical precursor behavior by LeFew, William R

“…Controlling and understanding the propagation of optical pulses through dispersive media forms the basis for optical communication, medical imaging, and other…”
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Optical precursor behavior by LeFew, William R

“…Controlling and understanding the propagation of optical pulses through dispersive media forms the basis for optical communication, medical imaging, and other…”
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Accurate description of optical precursors and their relation to weak-field coherent optical transients by LeFew, William R, Venakides, Stephanos, Gauthier, Daniel J

“…We study theoretically the propagation of a step-modulated optical field as it passes through a dispersive dielectric made up of a dilute collection of…”
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