Search Results - "LeDuc, B W"

Relationship of plasma and brain concentrations of caffeine and metabolites to benzodiazepine receptor binding and locomotor activity by Kaplan, G B, Greenblatt, D J, Leduc, B W, Thompson, M L, Shader, R I

“…CD-1 mice were treated with caffeine-sodium benzoate solution (caffeine doses: 0, 5, 15 or 30 mg/kg i.p.) to determine plasma and brain concentrations, effects…”
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Norcocaine and N-hydroxynorcocaine formation in human liver microsomes: role of cytochrome P-450 3A4 by LeDuc, B W, Sinclair, P R, Shuster, L, Sinclair, J F, Evans, J E, Greenblatt, D J

“…Cocaine was metabolized to norcocaine by microsomes prepared from lymphoblastoid cells expressing transfected human P-450 3A4. The specific activities of…”
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Two- and four-day rifampin chemoprophylaxis regimens induce oxidative metabolism by Borcherding, S M, Bastian, T L, Self, T H, Abou-Shala, N, LeDuc, B W, Lalonde, R L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Impaired absorption of tetracycline by colestipol is not reversed by orange juice by Friedman, H, Greenblatt, D J, LeDuc, B W

“…Nine volunteers received a 500 mg oral dose of tetracycline hydrochloride in three trials: A: With 180 ml water; B: With 30 gm colestipol in 180 ml water; C:…”
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Cocaine toxicity in cultured chicken hepatocytes: role of cytochrome P450 by LeDuc, B W, Sinclair, P R, Walton, H S, Sinclair, J F, Greenblatt, D J, Shuster, L

“…Cocaine (COC) causes liver damage in several species, including man. Chicken embryo hepatocyte cultures were evaluated as a model system to investigate the…”
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Effect of antipyrine coadministration on the kinetics of acetaminophen and lidocaine by BLYDEN, G. T, GREENBLATT, D. J, LEDUC, B. W, SCAVONE, J. M

“…Pharmacokinetic interactions between antipyrine and acetaminophen were evaluated in 7 healthy volunteers. On 3 occasions subjects received: 1, antipyrine 1.0 g…”
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Determination of zopiclone in plasma by liquid chromatography with application to steady-state monitoring by Miller, L G, Leduc, B W, Greenblatt, D J

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Contribution of the gastrointestinal tract to lorazepam conjugation and clonazepam nitroreduction by Ochs, H R, Greenblatt, D J, Eichelkraut, W, LeDuc, B W, Powers, J F, Hahn, N

“…Domestic pigs received single intravenous and oral doses of lorazepam or clonazepam (1 mg/kg), benzodiazepine derivatives biotransformed by glucuronide…”
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Differential effect of cigarette smoking on antipyrine oxidation versus acetaminophen conjugation by Scavone, J M, Greenblatt, D J, LeDuc, B W, Blyden, G T, Luna, B G, Harmatz, J S

“…The effect of cigarette smoking on drug oxidation and conjugation was studied using antipyrine and acetaminophen as marker compounds. For the antipyrine study,…”
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Poor bioavailability of CGS 8216 in a water/tween vehicle following intraperitoneal injection by LISTER, R. G, LEDUC, B. W, GREENBLATT, D. J, FILE, S. E

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Changes in salivary antipyrine pharmacokinetics during adolescence, correlated with age, hormonal levels and Tanner stage by Linday, L A, Greenblatt, D J, Warren, M P, Harmatz, J S, DeCresce, R, Cicalese, C, LeDuc, B W

“…To evaluate the effect of puberty on antipyrine metabolism, we measured antipyrine pharmacokinetics in 17 healthy subjects aged 6-21 years. The subjects…”
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Automated high-performance liquid chromatographic analysis of tetracycline in urine by LeDuc, B W, Greenblatt, D J, Friedman, H

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Improved high-performance liquid chromatographic assay of antipyrine, hydroxymethylantipyrine, 4-hydroxyantipyrine and norantipyrine in urine by Mikati, M A, Szabo, G K, Pylilo, R J, LeDuc, B W, Browne, T R, Greenblatt, D J

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Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice by Greenblatt, David J., Moltke, Lisa L., Harmatz, Jerold S., Chen, Gengsheng, Weemhoff, James L., Jen, Cheng, Kelley, Charles J., LeDuc, Barbara W., Zinny, Miguel A.

“…Background Components of grapefruit juice may impair the activity of intestinal cytochrome P450 (CYP) 3A enzymes, sometimes resulting in clinically important…”
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Recovery of CYP3A function following single doses of grapefruit juice by Greenblatt, D. J., Moltke, L. L., Harmatz, J. S., Chen, G., Weemhoff, J. L., Jen, C., Kelley, C. J., LeDuc, B. W., Zinny, M. A.

“…Clinical Pharmacology & Therapeutics (2003) 73, P94–P94; doi:…”
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Large theophylline requirements due to high theophylline clearance: verification by the antipyrine test by Blyden, G T, LeDuc, B W, Greenblatt, D J

“…An asthmatic patient required very high doses of theophylline (2.88 g/day by intravenous infusion) to maintain an adequate serum theophylline concentration (12…”
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Pharmacokinetics of intravenous caffeine: comparison of high-performance liquid chromatographic and gas chromatographic methods by Kennedy, J S, Leduc, B W, Scavone, J M, Harmatz, J S, Shader, R I, Greenblatt, D J

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Effect of potassium channel and cytochrome P450 inhibition on transient hypotension and survival during lipopolysaccharide-induced endotoxic shock in the rat by Clayton, Nicholas P, LeDuc, Barbara W, Kelly, Laurie J

“…The purpose of this study was to determine whether inhibition of potassium channels or cytochrome P450 attenuates the transient phase of hypotension during…”
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Two- and four-day rifampin chemoprophylaxis regimens induced oxidative metabolism by BORCHERDING, S. M, BASTIAN, T. L, SELF, T. H, NABIL ABOU-SHALA, LEDUC, B. W, LALONDE, R. L

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