Search Results - "LeDoux, J. E"

The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm by LeDoux, J E, Moscarello, J, Sears, R, Campese, V

“…Research on avoidance conditioning began in the late 1930s as a way to use laboratory experiments to better understand uncontrollable fear and anxiety…”
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Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala by Dębiec, J., Ledoux, J.E.

“…Consolidation is a process through which labile memories are made persistent [Science 287 (2000) 248]; [Annu Rev Psychol 55 (2004) 51]. When retrieved, a…”
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Emotion circuits in the brain by LEDOUX, J. E

“…The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area. Much of the progress has…”
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Different lateral amygdala outputs mediate reactions and actions elicited by a fear-arousing stimulus by Nader, K, Amorapanth, P, LeDoux, J. E

“…Fear-arousing stimuli elicit innate reactions and can reinforce acquisition of new responses. We tested whether mechanisms mediating these conditioned stimulus…”
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Lesions in the bed nucleus of the stria terminalis disrupt corticosterone and freezing responses elicited by a contextual but not by a specific cue-conditioned fear stimulus by Sullivan, G.M., Apergis, J., Bush, D.E.A., Johnson, L.R., Hou, M., Ledoux, J.E.

“…The bed nucleus of the stria terminalis (BNST) is believed to be a critical relay between the central nucleus of the amygdala (CE) and the paraventricular…”
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Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala by Johnson, L.R., Farb, C., Morrison, J.H., McEwen, B.S., Ledoux, J.E.

“…Glucocorticoids, released in high concentrations from the adrenal cortex during stressful experiences, bind to glucocorticoid receptors in nuclear and…”
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Fear conditioning induces associative long-term potentiation in the amygdala by Rogan, Michael T, Stäubli, Ursula V, LeDoux, Joseph E

“…Long-term potentiation (LTP) is an experience-dependent form of neural plasticity believed to involve mechanisms that underlie memory formation. LTP has been…”
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Unconditioned stimulus pathways to the amygdala: Effects of lesions of the posterior intralaminar thalamus on foot-shock-induced c-Fos expression in the subdivisions of the lateral amygdala by Lanuza, E, Moncho-Bogani, J, LeDoux, J.E

“…Abstract The lateral nucleus of the amygdala (LA) is a site of convergence for auditory (conditioned stimulus) and foot-shock (unconditioned stimulus) inputs…”
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Memory Consolidation of Auditory Pavlovian Fear Conditioning Requires Protein Synthesis and Protein Kinase A in the Amygdala by Schafe, Glenn E, LeDoux, Joseph E

“…Previous studies have shown that long-term potentiation (LTP) can be induced in the lateral nucleus of the amygdala (LA) after stimulation of central auditory…”
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Human fear-related motor neurocircuitry by Butler, T, Pan, H, Tuescher, O, Engelien, A, Goldstein, M, Epstein, J, Weisholtz, D, Root, J.C, Protopopescu, X, Cunningham-Bussel, A.C, Chang, L, Xie, X.-H, Chen, Q, Phelps, E.A, Ledoux, J.E, Stern, E, Silbersweig, D.A

“…Abstract Using functional magnetic resonance imaging and an experimental paradigm of instructed fear, we observed a striking pattern of decreased activity in…”
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The lateral amygdala processes the value of conditioned and unconditioned aversive stimuli by Blair, H.T., Sotres-Bayon, F., Moita, M.A.P., Ledoux, J.E.

“…The amygdala is critical for acquiring and expressing conditioned fear responses elicited by sensory stimuli that predict future punishment, but there is…”
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Differential Contribution of Amygdala and Hippocampus to Cued and Contextual Fear Conditioning by Phillips, R. G, LeDoux, J. E

“…The contribution of the amygdala and hippocampus to the acquisition of conditioned fear responses to a cue (a tone paired with footshock) and to context…”
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Fear conditioning induces distinct patterns of gene expression in lateral amygdala by Lamprecht, R., Dracheva, S., Assoun, S., LeDoux, J. E.

“…The lateral nucleus of the amygdala (LA) has been implicated in the formation of long‐term associative memory (LTM) of stimuli associated with danger through…”
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Unconditioned stimulus pathways to the amygdala: effects of posterior thalamic and cortical lesions on fear conditioning by Lanuza, E, Nader, K, Ledoux, J.E

“…Plasticity in the lateral nucleus of the amygdala is thought to be critical for the acquisition of Pavlovian fear conditioning. The pathways that transmit…”
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Fear learning transiently impairs hippocampal cell proliferation by Pham, K., McEwen, B.S., Ledoux, J.E., Nader, K.

“…We sought to determine whether contextual fear conditioning, a hippocampal-dependent task, would affect neurogenesis in the dentate gyrus of the hippocampus,…”
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Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala by Pitkänen, Asla, Savander, Vesa, LeDoux, Joseph E.

“…The amygdala is located in the medial aspects of the temporal lobe. In spite of the fact that the amygdala has been implicated in a variety of functions,…”
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Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning by Blair, H T, Schafe, G E, Bauer, E P, Rodrigues, S M, LeDoux, J E

“…Fear conditioning is a form of associative learning in which subjects come to express defense responses to a neutral conditioned stimulus (CS) that is paired…”
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Activation of ERK/MAP Kinase in the Amygdala Is Required for Memory Consolidation of Pavlovian Fear Conditioning by Schafe, Glenn E, Atkins, Coleen M, Swank, Michael W, Bauer, Elizabeth P, Sweatt, J. David, LeDoux, Joseph E

“…Although much has been learned about the neurobiological mechanisms underlying Pavlovian fear conditioning at the systems and cellular levels, relatively…”
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Intra-Amygdala Blockade of the NR2B Subunit of the NMDA Receptor Disrupts the Acquisition But Not the Expression of Fear Conditioning by Rodrigues, Sarina M, Schafe, Glenn E, LeDoux, Joseph E

“…The lateral nucleus of the amygdala (LA) is an essential component of the neural circuitry underlying Pavlovian fear conditioning. Although blockade of NMDA…”
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A Call to Action: Overcoming Anxiety Through Active Coping by LeDoux, Joseph E., Gorman, Jack M.

“…Of the medical specialties, psychiatry will ultimately be most called upon to deal with the aftermath of the Sep 11 World Trade Center tragedy. Basic science…”
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