Search Results - "LeClerc, Sophie"

Sphingomyelin-Rich Lipid Extract Collar for Canine Atopic Dermatitis by Segarra, Sergi, Sanmiguel, David, Zuriaga, Eliseo, Leclerc, Sophie, Cabañas, Jesús, Seigneuric, Estelle, Miquel, Aurélie, Vázquez, Ana, Ferrer, Lluís

“…The management of canine atopic dermatitis (CAD) is complex, and it needs to be multimodal, combining topical and systemic therapies. Given that the currently…”
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Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases by Eisenbrand, Gerhard, Endicott, Jane A, Lawrie, Alison, Meijer, Laurent, Damiens, Eve, Marie, Dominique, Tunnah, Paul, Leclerc, Sophie, Tang, Weici, Niederberger, Ellen, Leost, Maryse, Hoessel, Ralph, Marko, Doris, Nobel, Martin E. M

“…Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in traditional Chinese medicine to treat chronic diseases. Here we…”
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Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors by Gray, Nathanael S., Wodicka, Lisa, Andy-Mark W. H. Thunnissen, Norman, Thea C., Kwon, Soojin, Espinoza, F. Hernan, Morgan, David O., Barnes, Georjana, LeClerc, Sophie, Meijer, Laurent, Kim, Sung-Hou, Lockhart, David J., Schultz, Peter G.

“…Selective protein kinase inhibitors were developed on the basis of the unexpected binding mode of 2,6,9-trisubstituted purines to the adenosine…”
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Low Back Pain and Sacroiliitis on Cross-Sectional Abdominal Imaging for Axial Spondyloarthritis Diagnosis in Inflammatory Bowel Diseases by Fauny, Marine, Cohen, Nicolas, Morizot, Caroline, Leclerc-Jacob, Sophie, Wendling, Daniel, Lux, Guillaume, Laurent, Valérie, Blum, Alain, Netter, Patrick, Baumann, Cédric, Chary-Valckenaere, Isabelle, Peyrin-Biroulet, Laurent, Loeuille, Damien

“…Background: Joint damage is the most frequent extraintestinal manifestation in inflammatory bowel disease (IBD). Aims: The aim of the study was to assess the…”
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Direct Investigation of Halogen Bonds by Solid-State Multinuclear Magnetic Resonance Spectroscopy and Molecular Orbital Analysis by Viger-Gravel, Jasmine, Leclerc, Sophie, Korobkov, Ilia, Bryce, David L

“…Noncovalent interactions play a ubiquitous role in the structure, stability, and reactivity of a wide range of molecular and ionic cocrystals, pharmaceuticals,…”
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Correlation of 3-Isobutyl-2-methoxypyrazine to 3-Isobutyl-2-hydroxypyrazine during Maturation of Bell Pepper (Capsicum annuum) and Wine Grapes (Vitis vinifera) by Ryona, Imelda, Leclerc, Sophie, Sacks, Gavin L

“…Environmental factors affecting degradation of 3-isobutyl-2-methoxypyrazine (IBMP, “green pepper aroma”) in wine grapes (V. vinifera) are widely studied, but…”
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Screening the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2 kinase by Yang, Hua, Zheng, Shu, Meijer, Laurent, Li, Shi-min, Leclerc, Sophie, Yu, Lin-lin, Cheng, Jin-quan, Zhang, Su-zhan

“…To screen and evaluate the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 phosphatase. The affinity chromatography purified…”
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Eleven Years of Clozapine Experience in Autism Spectrum Disorder: Efficacy and Tolerance by Rothärmel, Maud, Szymoniak, Fanny, Pollet, Charlotte, Beherec, Laurène, Quesada, Pierre, Leclerc, Sophie, Belhaine, Amina, Rosier, Antoine, Guillin, Olivier

“…Autism spectrum disorders (ASDs) are neurodevelopmental disorders that comprise wide graduated clinical expressions but similar core symptoms (repetitive,…”
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Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum11Abbreviations: CDK, cyclin-dependent kinase; CDK1, cyclin-dependent kinase 1; and PfPK, Plasmodium falciparum protein kinase by Harmse, Leonie, van Zyl, Robyn, Gray, Nathanael, Schultz, Peter, Leclerc, Sophie, Meijer, Laurent, Doerig, Christian, Havlik, Ivan

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Febrile low back pain: Consider septic interspinous bursitis by Bauer, Elodie, Jacob-Leclerc, Sophie, Chary-Valckenaere, Isabelle, Loeuille, Damien

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Concordance of laparoscopic and laparotomic peritoneal cancer index using a two-step surgical protocol to select patients for cytoreductive surgery in advanced ovarian cancer by Angeles, Martina Aida, Migliorelli, Federico, Del, Mathilde, Martínez-Gómez, Carlos, Daix, Manon, Bétrian, Sarah, Gabiache, Erwan, Balagué, Gisèle, Leclerc, Sophie, Mery, Eliane, Gladieff, Laurence, Ferron, Gwénaël, Martinez, Alejandra

“…Purpose The aim of our study was to assess concordance of staging laparoscopy and cytoreductive surgery (CRS) peritoneal cancer index (PCI) when applying a…”
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Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? by Leclerc, S, Garnier, M, Hoessel, R, Marko, D, Bibb, J A, Snyder, G L, Greengard, P, Biernat, J, Wu, Y Z, Mandelkow, E M, Eisenbrand, G, Meijer, L

“…The bis-indole indirubin is an active ingredient of Danggui Longhui Wan, a traditional Chinese medicine recipe used in the treatment of chronic diseases such…”
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Perineal retraining improves conservative treatment for faecal incontinence: A multicentre randomized study by Damon, Henri, Siproudhis, Laurent, Faucheron, Jean-Luc, Piche, Thierry, Abramowitz, Laurent, Eléouet, Marianne, Etienney, Isabelle, Godeberge, Philippe, Valancogne, Guy, Denis, Angélique, Mion, François, Schott, Anne-Marie

“…Abstract Background Anal incontinence is a frequent complaint that profoundly affects quality of life. Our aim was to determine whether perineal retraining…”
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Properties and Potential Applications of Chemical Inhibitors of Cyclin-Dependent Kinases by Meijer, Laurent, Leclerc, Sophie, Leost, Maryse

“…Cyclin-dependent kinases (CDKs) trigger and co-ordinate the cell division cycle phases. They also play a role in neuronal cells and in the control of…”
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Devant une lombalgie fébrile penser à une bursite inter-épineuse infectieuse by Bauer, Élodie, Jacob-Leclerc, Sophie, Chary-Valckenaere, Isabelle, Loeuille, Damien

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Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine by De Azevedo, W F, Leclerc, S, Meijer, L, Havlicek, L, Strnad, M, Kim, S H

“…Cyclin-dependent kinases (cdk) control the cell division cycle (cdc). These kinases and their regulators are frequently deregulated in human tumours. A potent…”
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Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum by Harmse, Leonie, van Zyl, Robyn, Gray, Nathanael, Schultz, Peter, Leclerc, Sophie, Meijer, Laurent, Doerig, Christian, Havlik, Ivan

“…The development of novel chemotherapeutic agents has become an urgent task due to the development and rapid spread of drug resistance in Plasmodium falciparum,…”
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Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors by LEGRAVEREND, M, LUDWIG, O, BISAGNI, E, LECLERC, S, MEIJER, L, GIOCANTI, N, SADRI, R, FAVAUDON, V

“…Novel C-2, C-6, N-9 trisubstituted purines derived from the olomoucine/roscovitine lead structure were synthesized and evaluated for their ability to inhibit…”
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Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors by ORTEGA, Miguel A, MONTOYA, Maria E, ZARRANZ, Belén, JASO, Andrés, ALDANA, Ignacio, LECLERC, Sophie, MEIJER, Laurent, MONGE, Antonio

“…Protein kinases are involved in most physiological processes and in numerous diseases. Therefore, inhibitors of protein kinases have therefore a wide…”
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The prevalence of inflammatory sacroiliitis assessed on magnetic resonance imaging of inflammatory bowel disease: a retrospective study performed on 186 patients by Leclerc‐Jacob, S., Lux, G., Rat, A. C., Laurent, V., Blum, A., Chary‐Valckenaere, I., Peyrin‐Biroulet, L., Loeuille, D.

“…Summary Background Magnetic resonance imaging (MRI) colonography or enterography is increasingly used to assess disease activity and complications in…”
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