Search Results - "LeBrasseur, Nathan K"

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span by Robbins, Paul D, Jurk, Diana, Khosla, Sundeep, Kirkland, James L, LeBrasseur, Nathan K, Miller, Jordan D, Passos, João F, Pignolo, Robert J, Tchkonia, Tamar, Niedernhofer, Laura J

“…Senescence is the consequence of a signaling mechanism activated in stressed cells to prevent proliferation of cells with damage. Senescent cells (Sncs) often…”
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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues by Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J., Doolittle, Madison L., Zhang, Xu, LeBrasseur, Nathan K., Pignolo, Robert J., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Jurk, Diana, Passos, João F., Hickson, LaTonya J., Xue, Ailing, Monroe, David G., Tchkonia, Tamara, Kirkland, James L., Farr, Joshua N., Khosla, Sundeep

“…Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, in vivo senescent cell…”
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Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity by Palmer, Allyson K, Tchkonia, Tamara, LeBrasseur, Nathan K, Chini, Eduardo N, Xu, Ming, Kirkland, James L

“…Cellular senescence is a fundamental aging mechanism that has been implicated in many age-related diseases and is a significant cause of tissue dysfunction…”
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Cellular senescence mediates fibrotic pulmonary disease by Schafer, Marissa J., White, Thomas A., Iijima, Koji, Haak, Andrew J., Ligresti, Giovanni, Atkinson, Elizabeth J., Oberg, Ann L., Birch, Jodie, Salmonowicz, Hanna, Zhu, Yi, Mazula, Daniel L., Brooks, Robert W., Fuhrmann-Stroissnigg, Heike, Pirtskhalava, Tamar, Prakash, Y. S., Tchkonia, Tamara, Robbins, Paul D., Aubry, Marie Christine, Passos, João F., Kirkland, James L., Tschumperlin, Daniel J., Kita, Hirohito, LeBrasseur, Nathan K.

“…Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence…”
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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study by Justice, Jamie N., Nambiar, Anoop M., Tchkonia, Tamar, LeBrasseur, Nathan K., Pascual, Rodolfo, Hashmi, Shahrukh K., Prata, Larissa, Masternak, Michal M., Kritchevsky, Stephen B., Musi, Nicolas, Kirkland, James L.

“…Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis…”
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JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age by Xu, Ming, Tchkonia, Tamara, Ding, Husheng, Ogrodnik, Mikolaj, Lubbers, Ellen R., Pirtskhalava, Tamar, White, Thomas A., Johnson, Kurt O., Stout, Michael B., Mezera, Vojtech, Giorgadze, Nino, Jensen, Michael D., LeBrasseur, Nathan K., Kirkland, James L.

“…Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of…”
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Identification of Senescent Cells in the Bone Microenvironment by Farr, Joshua N, Fraser, Daniel G, Wang, Haitao, Jaehn, Katharina, Ogrodnik, Mikolaj B, Weivoda, Megan M, Drake, Matthew T, Tchkonia, Tamara, LeBrasseur, Nathan K, Kirkland, James L, Bonewald, Lynda F, Pignolo, Robert J, Monroe, David G, Khosla, Sundeep

“…ABSTRACT Cellular senescence is a fundamental mechanism by which cells remain metabolically active yet cease dividing and undergo distinct phenotypic…”
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Myostatin and sarcopenia: opportunities and challenges - a mini-review by White, Thomas A, LeBrasseur, Nathan K

“…The progressive loss of skeletal muscle mass, strength and/or function with advancing age, termed sarcopenia, poses a major threat to independence and quality…”
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Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice by Ogrodnik, Mikolaj, Evans, Shane A., Fielder, Edward, Victorelli, Stella, Kruger, Patrick, Salmonowicz, Hanna, Weigand, Bettina M., Patel, Ayush D., Pirtskhalava, Tamar, Inman, Christine L., Johnson, Kurt O., Dickinson, Stephanie L., Rocha, Azucena, Schafer, Marissa J., Zhu, Yi, Allison, David B., Zglinicki, Thomas, LeBrasseur, Nathan K., Tchkonia, Tamar, Neretti, Nicola, Passos, João F., Kirkland, James L., Jurk, Diana

“…Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐inflammatory senescence‐associated secretory phenotype (SASP), which is a…”
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Shear wave elastography of passive skeletal muscle stiffness: Influences of sex and age throughout adulthood by Eby, Sarah F, Cloud, Beth A, Brandenburg, Joline E, Giambini, Hugo, Song, Pengfei, Chen, Shigao, LeBrasseur, Nathan K, An, Kai-Nan

“…Abstract Background Numerous structural and compositional changes – related not only to age, but also activity level and sex – may affect skeletal muscle…”
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Targeting senescent cells enhances adipogenesis and metabolic function in old age by Xu, Ming, Palmer, Allyson K, Ding, Husheng, Weivoda, Megan M, Pirtskhalava, Tamar, White, Thomas A, Sepe, Anna, Johnson, Kurt O, Stout, Michael B, Giorgadze, Nino, Jensen, Michael D, LeBrasseur, Nathan K, Tchkonia, Tamar, Kirkland, James L

“…Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy…”
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The clinical impact and biological mechanisms of skeletal muscle aging by Aversa, Zaira, Zhang, Xu, Fielding, Roger A., Lanza, Ian, LeBrasseur, Nathan K.

“…Skeletal muscle is a highly plastic tissue that remarkably adapts to diverse stimuli including exercise, injury, disuse, and, as discussed here, aging. Humans…”
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Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease by Schafer, Marissa J., Atkinson, Elizabeth J., Vanderboom, Patrick M., Kotajarvi, Brian, White, Thomas A., Moore, Matthew M., Bruce, Charles J., Greason, Kevin L., Suri, Rakesh M., Khosla, Sundeep, Miller, Jordan D., Bergen, H. Robert, LeBrasseur, Nathan K.

“…Growth and differentiation factor 11 (GDF11) is a transforming growth factor β superfamily member with a controversial role in aging processes. We have…”
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Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue by Schafer, Marissa J, White, Thomas A, Evans, Glenda, Tonne, Jason M, Verzosa, Grace C, Stout, Michael B, Mazula, Daniel L, Palmer, Allyson K, Baker, Darren J, Jensen, Michael D, Torbenson, Michael S, Miller, Jordan D, Ikeda, Yasuhiro, Tchkonia, Tamara, van Deursen, Jan M, Kirkland, James L, LeBrasseur, Nathan K

“…Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however,…”
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Exercise reduces circulating biomarkers of cellular senescence in humans by Englund, Davis A., Sakamoto, Ayumi E., Fritsche, Chad M., Heeren, Amanda A., Zhang, Xu, Kotajarvi, Brian R., Lecy, Denise R., Yousefzadeh, Matthew J., Schafer, Marissa J., White, Thomas A., Atkinson, Elizabeth J., LeBrasseur, Nathan K.

“…Cellular senescence has emerged as a significant and potentially tractable mechanism of aging and multiple aging‐related conditions. Biomarkers of senescent…”
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Metabolic benefits of resistance training and fast glycolytic skeletal muscle by LeBrasseur, Nathan K, Walsh, Kenneth, Arany, Zoltan

“…Skeletal muscle exhibits remarkable plasticity with respect to its metabolic properties. Recent work has shown that interventions such as resistance training,…”
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TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle by Koh, Jin-Ho, Johnson, Matthew L, Dasari, Surendra, LeBrasseur, Nathan K, Vuckovic, Ivan, Henderson, Gregory C, Cooper, Shawna A, Manjunatha, Shankarappa, Ruegsegger, Gregory N, Shulman, Gerald I, Lanza, Ian R, Nair, K Sreekumaran

“…Diet-induced insulin resistance (IR) adversely affects human health and life span. We show that muscle-specific overexpression of human mitochondrial…”
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The senescence-associated secretome as an indicator of age and medical risk by Schafer, Marissa J, Zhang, Xu, Kumar, Amanika, Atkinson, Elizabeth J, Zhu, Yi, Jachim, Sarah, Mazula, Daniel L, Brown, Ashley K, Berning, Michelle, Aversa, Zaira, Kotajarvi, Brian, Bruce, Charles J, Greason, Kevin L, Suri, Rakesh M, Tracy, Russell P, Cummings, Steven R, White, Thomas A, LeBrasseur, Nathan K

“…Produced by senescent cells, the senescence-associated secretory phenotype (SASP) is a potential driver of age-related dysfunction. We tested whether…”
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Brd2 disruption in mice causes severe obesity without Type 2 diabetes by Wang, Fangnian, Liu, Hongsheng, Blanton, Wanda P, Belkina, Anna, Lebrasseur, Nathan K, Denis, Gerald V

“…Certain human subpopulations are metabolically healthy but obese, or metabolically obese but normal weight; such mutations uncouple obesity from glucose…”
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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis by Farr, Joshua N, Saul, Dominik, Doolittle, Madison L, Kaur, Japneet, Rowsey, Jennifer L, Vos, Stephanie J, Froemming, Mitchell N, Lagnado, Anthony B, Zhu, Yi, Weivoda, Megan, Ikeno, Yuji, Pignolo, Robert J, Niedernhofer, Laura J, Robbins, Paul D, Jurk, Diana, Passos, João F, LeBrasseur, Nathan K, Tchkonia, Tamara, Kirkland, James L, Monroe, David G, Khosla, Sundeep

“…Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in…”
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