Search Results - "LeBon, Lauren"

Dynamic Ligand Discrimination in the Notch Signaling Pathway by Nandagopal, Nagarajan, Santat, Leah A., LeBon, Lauren, Sprinzak, David, Bronner, Marianne E., Elowitz, Michael B.

“…The Notch signaling pathway comprises multiple ligands that are used in distinct biological contexts. In principle, different ligands could activate distinct…”
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The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes by Wong, Yao Liang, LeBon, Lauren, Edalji, Rohinton, Lim, Hock Ben, Sun, Chaohong, Sidrauski, Carmela

“…eIF2B is a dedicated guanine nucleotide exchange factor for eIF2, the GTPase that is essential to initiate mRNA translation. The integrated stress response…”
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eIF2B activator prevents neurological defects caused by a chronic integrated stress response by Wong, Yao Liang, LeBon, Lauren, Basso, Ana M, Kohlhaas, Kathy L, Nikkel, Arthur L, Robb, Holly M, Donnelly-Roberts, Diana L, Prakash, Janani, Swensen, Andrew M, Rubinstein, Nimrod D, Krishnan, Swathi, McAllister, Fiona E, Haste, Nicole V, O'Brien, Jonathon J, Roy, Margaret, Ireland, Andrea, Frost, Jennifer M, Shi, Lei, Riedmaier, Stephan, Martin, Kathleen, Dart, Michael J, Sidrauski, Carmela

“…The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate…”
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Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states by LeBon, Lauren, Lee, Tom V, Sprinzak, David, Jafar-Nejad, Hamed, Elowitz, Michael B

“…The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can be tuned by Fringe glycosyltransferases. A major…”
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Specific activation of the integrated stress response uncovers regulation of central carbon metabolism and lipid droplet biogenesis by Labbé, Katherine, LeBon, Lauren, King, Bryan, Vu, Ngoc, Stoops, Emily H., Ly, Nina, Lefebvre, Austin E. Y. T., Seitzer, Phillip, Krishnan, Swathi, Heo, Jin-Mi, Bennett, Bryson, Sidrauski, Carmela

“…The integrated stress response (ISR) enables cells to cope with a variety of insults, but its specific contribution to downstream cellular outputs remains…”
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Mutual inactivation of Notch receptors and ligands facilitates developmental patterning by Sprinzak, David, Lakhanpal, Amit, LeBon, Lauren, Garcia-Ojalvo, Jordi, Elowitz, Michael B

“…Developmental patterning requires juxtacrine signaling in order to tightly coordinate the fates of neighboring cells. Recent work has shown that Notch and…”
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Sugar phosphate activation of the stress sensor eIF2B by Hao, Qi, Heo, Jin-Mi, Nocek, Boguslaw P., Hicks, Kevin G., Stoll, Vincent S., Remarcik, Clint, Hackett, Sean, LeBon, Lauren, Jain, Rinku, Eaton, Dan, Rutter, Jared, Wong, Yao Liang, Sidrauski, Carmela

“…The multi-subunit translation initiation factor eIF2B is a control node for protein synthesis. eIF2B activity is canonically modulated through…”
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Correction: Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states by LeBon, Lauren, Lee, Tom V, Sprinzak, David, Jafar-Nejad, Hamed, Elowitz, Michael B

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Cis -interactions between Notch and Delta generate mutually exclusive signalling states by Elowitz, Michael B, Sprinzak, David, Lakhanpal, Amit, LeBon, Lauren, Santat, Leah A, Fontes, Michelle E, Anderson, Graham A, Garcia-Ojalvo, Jordi

“…The Notch-Delta signalling pathway allows communication between neighbouring cells during development. It has a critical role in the formation of…”
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GDF15 is a dynamic biomarker of the integrated stress response in the central nervous system by Asundi, Jyoti, Zhang, Chunlian, Donnelly‐Roberts, Diana, Solorio, Josè Zavala, Challagundla, Malleswari, Connelly, Caitlin, Boch, Christina, Chen, Jun, Richter, Mario, Maneshi, Mohammad Mehdi, Swensen, Andrew M., Lebon, Lauren, Schiffmann, Raphael, Sanyal, Subhabrata, Sidrauski, Carmela, Kolumam, Ganesh, Baruch, Amos

“…Aim Characterize Growth Differentiation Factor 15 (GDF15) as a secreted biomarker of the integrated stress response (ISR) within the central nervous system…”
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The logic of receptor-ligand interactions in the Notch signaling pathway by LeBon, Lauren

“…The Notch signaling pathway enables neighboring cells to coordinate developmental fates in diverse processes such as angiogenesis, neuronal differentiation,…”
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Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning: e1002069 by Sprinzak, David, Lakhanpal, Amit, LeBon, Lauren, Garcia-Ojalvo, Jordi, Elowitz, Michael B

“…Developmental patterning requires juxtacrine signaling in order to tightly coordinate the fates of neighboring cells. Recent work has shown that Notch and…”
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The logic of receptor-ligand interactions in the Notch signaling pathway by LeBon, Lauren

“…The Notch signaling pathway enables neighboring cells to coordinate developmental fates in diverse processes such as angiogenesis, neuronal differentiation,…”
Get full text