Search Results - "LeBold, David G."

Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury by Bakshi, Asha, Shimizu, Saori, Keck, Carrie A., Cho, Sean, LeBold, David G., Morales, Diego, Arenas, Ernest, Snyder, Evan Y., Watson, Deborah J., McIntosh, Tracy K.

“…We sought to evaluate the potential of C17.2 neural progenitor cells (NPCs) engineered to secrete glial cell line‐derived neurotrophic factor (GDNF) to…”
Get full text

Effects of estradiol on cognition and hippocampal pathology after lateral fluid percussion brain injury in female rats by Lebesgue, Diane, LeBold, David G, Surles, Nathan O, Morales, Diego M, Etgen, Anne M, Zukin, R Suzanne, Saatman, Kathryn E

“…Studies involving animal models of acute central nervous system (CNS) stroke and trauma strongly indicate that sex and/or hormonal status are important…”
Get more information

Caspase-mediated cell death predominates following engraftment of neural progenitor cells into traumatically injured rat brain by Bakshi, Asha, Keck, Carrie A., Koshkin, Vadim S., LeBold, David G., Siman, Robert, Snyder, Evan Y., McIntosh, Tracy K.

“…Neural progenitor cells (NPCs) have been shown to be a promising therapy for cell replacement and gene transfer in neurological diseases including traumatic…”
Get full text

Erythrocyte-bound tissue plasminogen activator is neuroprotective in experimental traumatic brain injury by Stein, Sherman C, Ganguly, Kumkum, Belfield, Caitlin M, Xu, Xiangsheng, Swanson, Edward W, Chen, Xiao-Han, Browne, Kevin D, Johnson, Victoria E, Smith, Douglas H, LeBold, David G, Cines, Douglas B, Muzykantov, Vladimir R, Muzykhantov, Vladimir R

“…The purpose of this study was to test the effects of exogenous tissue plasminogen activator (tPA) in traumatic brain injury (TBI).We tested two different tPA…”
Get more information

Tissue sparing and functional recovery following experimental traumatic brain injury is provided by treatment with an anti-myelin-associated glycoprotein antibody by Thompson, Hilaire J., Marklund, Niklas, LeBold, David G., Morales, Diego M., Keck, Carrie A., Vinson, Mary, Royo, Nicolas C., Grundy, Robert, McIntosh, Tracy K.

“…Axonal injury is a hallmark of traumatic brain injury (TBI) and is associated with a poor clinical outcome. Following central nervous system injury, axons…”
Get full text

Cognitive evaluation of traumatically brain-injured rats using serial testing in the Morris water maze by Thompson, Hilaire J, LeBold, David G, Marklund, Niklas, Morales, Diego M, Hagner, Andrew P, McIntosh, Tracy K

“…As deficits in memory and cognition are commonly observed in survivors of traumatic brain injury (TBI), causing reduced quality of life for the patient, a…”
Get more information

The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury by Keck, Carrie A, Thompson, Hilaire J, Pitkänen, Asla, LeBold, David G, Morales, Diego M, Plevy, Jamie B, Puri, Rishi, Zhao, Boyu, Dichter, Marc, McIntosh, Tracy K

“…To evaluate the therapeutic efficacy of two antiepileptic compounds, RWJ-333369 and RWJ-333369-A in a well-established experimental model of lateral fluid…”
Get more information