Search Results - "Le Vay, Kristian"

Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules by Morasch, Matthias, Liu, Jonathan, Dirscherl, Christina F., Ianeselli, Alan, Kühnlein, Alexandra, Le Vay, Kristian, Schwintek, Philipp, Islam, Saidul, Corpinot, Mérina K., Scheu, Bettina, Dingwell, Donald B., Schwille, Petra, Mutschler, Hannes, Powner, Matthew W., Mast, Christof B., Braun, Dieter

“…Non-equilibrium conditions must have been crucial for the assembly of the first informational polymers of early life, by supporting their formation and…”
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Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme by Watkins, Daniel W., Jenkins, Jonathan M. X., Grayson, Katie J., Wood, Nicola, Steventon, Jack W., Le Vay, Kristian K., Goodwin, Matthew I., Mullen, Anna S., Bailey, Henry J., Crump, Matthew P., MacMillan, Fraser, Mulholland, Adrian J., Cameron, Gus, Sessions, Richard B., Mann, Stephen, Anderson, J. L. Ross

“…Although catalytic mechanisms in natural enzymes are well understood, achieving the diverse palette of reaction chemistries in re-engineered native proteins…”
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Ribozyme activity modulates the physical properties of RNA-peptide coacervates by Le Vay, Kristian Kyle, Salibi, Elia, Ghosh, Basusree, Tang, T Y Dora, Mutschler, Hannes

“…Condensed coacervate phases are now understood to be important features of modern cell biology, as well as valuable protocellular models in origin-of-life…”
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Compartmentalised RNA catalysis in membrane-free coacervate protocells by Drobot, Björn, Iglesias-Artola, Juan M., Le Vay, Kristian, Mayr, Viktoria, Kar, Mrityunjoy, Kreysing, Moritz, Mutschler, Hannes, Tang, T-Y Dora

“…Phase separation of mixtures of oppositely charged polymers provides a simple and direct route to compartmentalisation via complex coacervation, which may have…”
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Generation of RNA with 2', 3'-Cyclic Phosphates by Deoxyribozyme Cleavage in Frozen Solutions by Le Vay, Kristian K, Mutschler, Hannes

“…The generation of terminal 2', 3'-cyclic phosphates on RNA oligomers is an important process in the study of tRNA splicing and repair, ribozyme catalysis, and…”
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Ribozyme-mediated RNA synthesis and replication in a model Hadean microenvironment by Salditt, Annalena, Karr, Leonie, Salibi, Elia, Le Vay, Kristian, Braun, Dieter, Mutschler, Hannes

“…Enzyme-catalyzed replication of nucleic acid sequences is a prerequisite for the survival and evolution of biological entities. Before the advent of protein…”
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PCR Methods for the Generation of Catalytic ssDNA by Szokoli, Deni, Le Vay, Kristian K, Mutschler, Hannes

“…The ability to produce single-stranded DNA on a preparative scale from low amounts of starting templates is necessary for most research involving…”
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Prebiotically Plausible RNA Activation Compatible with Ribozyme‐Catalyzed Ligation by Song, Emilie Yeonwha, Jiménez, Eddy Ivanhoe, Lin, Huacan, Le Vay, Kristian, Krishnamurthy, Ramanarayanan, Mutschler, Hannes

“…RNA‐catalyzed RNA ligation is widely believed to be a key reaction for primordial biology. However, since typical chemical routes towards activating RNA…”
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Enhanced Ribozyme‐Catalyzed Recombination and Oligonucleotide Assembly in Peptide‐RNA Condensates by Le Vay, Kristian, Song, Emilie Yeonwha, Ghosh, Basusree, Tang, T.‐Y. Dora, Mutschler, Hannes

“…The ability of RNA to catalyze RNA ligation is critical to its central role in many prebiotic model scenarios, in particular the copying of information during…”
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Nucleic Acid Catalysis under Potential Prebiotic Conditions by Le Vay, Kristian, Salibi, Elia, Song, Emilie Y., Mutschler, Hannes

“…Catalysis by nucleic acids is indispensable for extant cellular life, and it is widely accepted that nucleic acid enzymes were crucial for the emergence of…”
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Designer artificial membrane binding proteins to direct stem cells to the myocardium by Xiao, Wenjin, Green, Thomas I. P, Liang, Xiaowen, Delint, Rosalia Cuahtecontzi, Perry, Guillaume, Roberts, Michael S, Le Vay, Kristian, Back, Catherine R, Ascione, Raimomdo, Wang, Haolu, Race, Paul R, Perriman, Adam W

“…We present a new cell membrane modification methodology where the inherent heart tissue homing properties of the infectious bacteria Streptococcus gordonii are…”
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Functionalized Triblock Copolymer Vectors for the Treatment of Acute Lymphoblastic Leukemia by Deller, Robert C, Diamanti, Paraskevi, Morrison, Gabriella, Reilly, James, Ede, Benjamin C, Richardson, Robert, Le Vay, Kristian, Collins, Andrew M, Blair, Allison, Perriman, Adam W

“…The chemotherapeutic Parthenolide is an exciting new candidate for the treatment of acute lymphoblastic leukemia, but like many other small-molecule drugs, it…”
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Präbiotisch plausible RNA‐Aktivierung kompatibel mit ribozymkatalysierter Ligation by Song, Emilie Yeonwha, Jiménez, Eddy Ivanhoe, Lin, Huacan, Le Vay, Kristian, Krishnamurthy, Ramanarayanan, Mutschler, Hannes

“…RNA‐katalysierte RNA‐Ligation wird häufig als Schlüsselreaktion für die Ursprünge der Biologie angesehen. Da jedoch typische Reaktionswege zur Aktivierung von…”
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Enhanced Ribozyme‐Catalyzed Recombination and Oligonucleotide Assembly in Peptide‐RNA Condensates by Le Vay, Kristian, Song, Emilie Yeonwha, Ghosh, Basusree, Tang, T.‐Y. Dora, Mutschler, Hannes

“…The ability of RNA to catalyze RNA ligation is critical to its central role in many prebiotic model scenarios, in particular the copying of information during…”
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How DNA and RNA subunits might have formed to make the first genetic alphabet by Le Vay, Kristian, Mutschler, Hannes

“…Understanding the prebiotic origins of the nucleic acids is a long-standing challenge. The latest experiments support the idea that the first nucleic acid…”
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A plausible route to the first genetic alphabet by Le Vay, Kristian, Mutschler, Hannes

“…Workers from the same research group as Xu et at. had previously identified4 a network of reactions promoted by ultraviolet light that resulted in the…”
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Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules by Morasch, Matthias, Liu, Jonathan, Dirscherl, Christina F, Ianeselli, Alan, Kühnlein, Alexandra, Vay, Kristian Le, Schwintek, Philipp, Islam, Saidul, Corpinot, Mérina K, Scheu, Bettina, Dingwell, Donald B, Schwille, Petra, Mutschler, Hannes, Powner, Matthew W, Mast, Christof B, Braun, Dieter

“…Nature Chemistry volume 11, pages 779-788, year 2019 Non-equilibrium conditions must have been crucial for the assembly of the first informational polymers of…”
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Cover Feature: Nucleic Acid Catalysis under Potential Prebiotic Conditions (Chem. Asian J. 2/2020) by Le Vay, Kristian, Salibi, Elia, Song, Emilie Y., Mutschler, Hannes

“…The cover feature illustrates various environmental factors influencing nucleic acid catalysis on early Earth, including temperature, pH, metal ion…”
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Controlling Protein Nanocage Assembly with Hydrostatic Pressure by Le Vay, Kristian, Carter, Ben M, Watkins, Daniel W, Dora Tang, T.-Y, Ting, Valeska P, Cölfen, Helmut, Rambo, Robert P, Smith, Andrew J, Ross Anderson, J. L, Perriman, Adam W

“…Controlling the assembly and disassembly of nanoscale protein cages for the capture and internalization of protein or non-proteinaceous components is…”
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The streptococcal multidomain fibrillar adhesin CshA has an elongated polymeric architecture by Back, Catherine R., Higman, Victoria A., Le Vay, Kristian, Patel, Viren V., Parnell, Alice E., Frankel, Daniel, Jenkinson, Howard F., Burston, Steven G., Crump, Matthew P., Nobbs, Angela H., Race, Paul R.

“…The cell surfaces of many bacteria carry filamentous polypeptides termed adhesins that enable binding to both biotic and abiotic surfaces. Surface adherence is…”
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