Potential evolution of hydrolysis spectrum for AmpC  -lactamase of Escherichia coli

Potential evolution of hydrolysis spectrum for AmpC  -lactamase of Escherichia coli

Escherichia coli harbours a chromosome-encoded ampC gene that is expressed naturally at a very low level due to a weak promoter. Spontaneous mutations in the promoter region may induce constitutive overproduction of the AmpC [beta]-lactamase, thus conferring resistance to narrow-spectrum cephalospor...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy Vol. 63; no. 1; pp. 216 - 218
Main Authors: Le Turnier, S., Nordmann, P., Eb, F., Mammeri, H.
Format: Journal Article
Language:English
Published: Oxford Oxford Publishing Limited (England) 01-01-2009
Subjects:
Drug resistance
E coli
Gene expression
Medical research
Substrates
Online Access:Get full text
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Summary:Escherichia coli harbours a chromosome-encoded ampC gene that is expressed naturally at a very low level due to a weak promoter. Spontaneous mutations in the promoter region may induce constitutive overproduction of the AmpC [beta]-lactamase, thus conferring resistance to narrow-spectrum cephalosporins. Recently, a novel mechanism of resistance to [beta]-lactams has been identified, cephalosporinases with broadened substrate activity in several clinical isolates of Enterobacteriaceae.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkn443