Search Results - "Le Texier, Laetitia"

Complete response to PD-1 blockade following EBV-specific T-cell therapy in metastatic nasopharyngeal carcinoma by Smith, Corey, McGrath, Margaret, Neller, Michelle A., Matthews, Katherine K., Crooks, Pauline, Le Texier, Laetitia, Panizza, Benedict, Porceddu, Sandro, Khanna, Rajiv

“…Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV)-associated heterogeneous disease and is characterized by peritumoral immune infiltrate. Adoptive…”
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Breakthrough SARS-COV-2 infection induces broad anti-viral T cell immunity by Lineburg, Katie Eireann, Crooks, Pauline, Raju, Jyothy, Le Texier, Laetitia, Khaledi, Panteha, Berry, Kiana, Swaminathan, Srividhya, Panikkar, Archana, Rehan, Sweera, Guppy-Coles, Kristyan, Neller, Michelle Anne, Khanna, Rajiv, Smith, Corey

“…Vaccines have curtailed the devastation wrought by COVID-19. Nevertheless, emerging variants result in a high incidence of breakthrough infections. Here we…”
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LIMLE, a new molecule over-expressed following activation, is involved in the stimulatory properties of dendritic cells by Le Texier, Laëtitia, Durand, Justine, Lavault, Amélie, Hulin, Philippe, Collin, Olivier, Le Bras, Yvan, Cuturi, Maria-Cristina, Chiffoleau, Elise

“…Dendritic cells are sentinels of the immune system distributed throughout the body, that following danger signals will migrate to secondary lymphoid organs to…”
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Autologous CMV-specific T cells are a safe adjuvant immunotherapy for primary glioblastoma multiforme by Smith, Corey, Lineburg, Katie E, Martins, J Paulo, Ambalathingal, George R, Neller, Michelle A, Morrison, Beth, Matthews, Katherine K, Rehan, Sweera, Crooks, Pauline, Panikkar, Archana, Beagley, Leone, Le Texier, Laetitia, Srihari, Sriganesh, Walker, David, Khanna, Rajiv

“…BACKGROUNDThe recent failure of checkpoint-blockade therapies for glioblastoma multiforme (GBM) in late-phase clinical trials has directed interest toward…”
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Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial by Kennedy, Glen A, MBBS, Varelias, Antiopi, PhD, Vuckovic, Slavica, PhD, Le Texier, Laetitia, PhD, Gartlan, Kate H, PhD, Zhang, Ping, MD, Thomas, Gethin, PhD, Anderson, Lisa, BBiomedSc, Boyle, Glen, PhD, Cloonan, Nicole, PhD, Leach, Justine, BN, Sturgeon, Elise, BN, Avery, Judy, BHlthSc, Olver, Stuart D, BSc, Lor, Mary, BSc, Misra, Ashish K, MBBS, Hutchins, Cheryl, PhD, Morton, A James, MBBS, Durrant, Simon TS, MBBS, Subramoniapillai, Elango, MBBS, Butler, Jason P, MMedSci, Curley, Cameron I, MBBS, MacDonald, Kelli P A, PhD, Tey, Siok-Keen, MBBS, Hill, Geoffrey R, Prof

“…Summary Background Interleukin 6 mediates graft-versus-host disease (GVHD) in experimental allogeneic stem-cell transplantation (allogeneic SCT) and represents…”
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T cell repertoire remodeling following post-transplant T cell therapy coincides with clinical response by Smith, Corey, Corvino, Dillon, Beagley, Leone, Rehan, Sweera, Neller, Michelle A, Crooks, Pauline, Matthews, Katherine K, Solomon, Matthew, Le Texier, Laetitia, Campbell, Scott, Francis, Ross S, Chambers, Daniel, Khanna, Rajiv

“…BACKGROUNDImpaired T cell immunity in transplant recipients is associated with infection-related morbidity and mortality. We recently reported the successful…”
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Ablation of CD8+ T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3 by Swaminathan, Srividhya, Lineburg, Katie E., Panikkar, Archana, Raju, Jyothy, Murdolo, Lawton D., Szeto, Christopher, Crooks, Pauline, Le Texier, Laetitia, Rehan, Sweera, Dewar-Oldis, Michael J., Barnard, Peter J., Ambalathingal, George R., Neller, Michelle A., Short, Kirsty R., Gras, Stephanie, Khanna, Rajiv, Smith, Corey

“…The emergence of the SARS-CoV-2 Omicron variant has raised concerns of escape from vaccine-induced immunity. A number of studies have demonstrated a reduction…”
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SARS-CoV-2-specific T cells generated for adoptive immunotherapy are capable of recognizing multiple SARS-CoV-2 variants by Panikkar, Archana, Lineburg, Katie E, Raju, Jyothy, Chew, Keng Yih, Ambalathingal, George R, Rehan, Sweera, Swaminathan, Srividhya, Crooks, Pauline, Le Texier, Laetitia, Beagley, Leone, Best, Shannon, Solomon, Matthew, Matthews, Katherine K, Srihari, Sriganesh, Neller, Michelle A, Short, Kirsty R, Khanna, Rajiv, Smith, Corey

“…Adoptive T-cell immunotherapy has provided promising results in the treatment of viral complications in humans, particularly in the context of…”
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Tmem176B and Tmem176A are associated with the immature state of dendritic cells by Condamine, Thomas, Le Texier, Laetitia, Howie, Duncan, Lavault, Amelie, Hill, Marcelo, Halary, Frank, Cobbold, Steve, Waldmann, Herman, Cuturi, Maria‐Cristina, Chiffoleau, Elise

“…Knock‐down of the expression of Tmem176B and Tmem176A in immature DC leads to increase of the DC stimulatory properties. DCs play a central role in the…”
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Off-the-shelf’ allogeneic antigen-specific adoptive T-cell therapy for the treatment of multiple EBV-associated malignancies by Sinha, Debottam, Srihari, Sriganesh, Beckett, Kirrliee, Le Texier, Laetitia, Solomon, Matthew, Panikkar, Archana, Ambalathingal, George R, Lekieffre, Lea, Crooks, Pauline, Rehan, Sweera, Neller, Michelle A., Smith, Corey, Khanna, Rajiv

“…BackgroundEpstein-Barr virus (EBV), an oncogenic human gammaherpesvirus, is associated with a wide range of human malignancies of epithelial and B-cell origin…”
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Limited Recognition of Highly Conserved Regions of SARS-CoV-2 by Swaminathan, Srividhya, Lineburg, Katie E, Ambalathingal, George R, Crooks, Pauline, Grant, Emma J, Mohan, Sonali V, Raju, Jyothy, Panikkar, Archana, Le Texier, Laetitia, Tong, Zheng Wei Marcus, Chew, Keng Yih, Neller, Michelle A, Short, Kirsty R, Gowda, Harsha, Gras, Stephanie, Khanna, Rajiv, Smith, Corey

“…Understanding the immune response to severe acute respiratory syndrome coronavirus (SARS-CoV-2) is critical to overcome the current coronavirus disease…”
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Rapid whole‐blood assay to detect SARS‐CoV‐2‐specific memory T‐cell immunity following a single dose of AstraZeneca ChAdOx1‐S COVID‐19 vaccine by Lineburg, Katie E, Neller, Michelle A, Ambalathingal, George R, Le Texier, Laetitia, Raju, Jyothy, Swaminathan, Srividhya, Lekieffre, Lea, Smith, Caitlyn, Rehan, Sweera, Crooks, Pauline, Panikkar, Archana, Srihari, Sriganesh, Khanna, Rajiv, Smith, Corey

“…Objectives With the ongoing emergence of SARS‐CoV‐2 variants and potential to evade vaccine‐induced neutralisation, understanding the magnitude and breadth of…”
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Immunoregulatory Function of IL-27 and TGF-β1 in Cardiac Allograft Transplantation by LETEXIER, Laetitia, THEBAULT, Pamela, CARVALHO-GASPAR, Manuela, VIGNARD, Virginie, MERIEAU, Emmanuel, USAL, Claire, CUTURI, Maria-Cristina, WOOD, Kathryn J, CHIFFOLEAU, Elise

“…Deciphering the mechanisms of tolerance represents a crucial aim of research in transplantation. We previously identified by DNA chip interleukin (IL)-27 p28…”
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Bone Marrow Regulatory T Cells Are a Unique Population, Supported by Niche-Specific Cytokines and Plasmacytoid Dendritic Cells, and Required for Chronic Graft-Versus-Host Disease Control by Nicholls, Jemma, Cao, Benjamin, Le Texier, Laetitia, Xiong, Laura Yan, Hunter, Christopher R, Llanes, Genesis, Aguliar, Ethan G, Schroder, Wayne A, Phipps, Simon, Lynch, Jason P, Cao, Huimin, Heazlewood, Shen Y, Williams, Brenda, Clouston, Andrew D, Nefzger, Christian M, Polo, Jose M, Nilsson, Susan K, Blazar, Bruce R, MacDonald, Kelli P A

“…Regulatory T cell (Treg) reconstitution is essential for reestablishing tolerance and maintaining homeostasis following stem-cell transplantation. We…”
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The C-Type Lectin-Like Receptor CLEC-1, Expressed by Myeloid Cells and Endothelial Cells, Is Up-Regulated by Immunoregulatory Mediators and Moderates T Cell Activation by Thebault, Pamela, Lhermite, Natacha, Tilly, Gaelle, Le Texier, Laetitia, Quillard, Thibaut, Heslan, Michele, Anegon, Ignacio, Soulillou, Jean-Paul, Brouard, Sophie, Charreau, Beatrice, Cuturi, Maria-Cristina, Chiffoleau, Elise

“…C-type lectin receptors have recently been described as playing crucial roles in immunity and homeostasis since these proteins are able to recognize pathogens…”
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Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses by Lopez Robles, Maria Dolores, Pallier, Annaick, Huchet, Virginie, Le Texier, Laetitia, Remy, Severine, Braudeau, Cecile, Delbos, Laurence, Moreau, Aurelie, Louvet, Cedric, Brosseau, Carole, Royer, Pierre-Joseph, Magnan, Antoine, Halary, Franck, Josien, Regis, Cuturi, Maria-Cristina, Anegon, Ignacio, Chiffoleau, Elise

“…Dendritic cells (DCs) represent essential antigen-presenting cells that are critical for linking innate and adaptive immunity, and influencing T-cell…”
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CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease by Alexander, Kylie A, Flynn, Ryan, Lineburg, Katie E, Kuns, Rachel D, Teal, Bianca E, Olver, Stuart D, Lor, Mary, Raffelt, Neil C, Koyama, Motoko, Leveque, Lucie, Le Texier, Laetitia, Melino, Michelle, Markey, Kate A, Varelias, Antiopi, Engwerda, Christian, Serody, Jonathan S, Janela, Baptiste, Ginhoux, Florent, Clouston, Andrew D, Blazar, Bruce R, Hill, Geoffrey R, MacDonald, Kelli P A

“…Chronic GVHD (cGVHD) is the major cause of late, nonrelapse death following stem cell transplantation and characteristically develops in organs such as skin…”
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Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease by Le Texier, Laëtitia, Lineburg, Katie E, Cao, Benjamin, McDonald-Hyman, Cameron, Leveque-El Mouttie, Lucie, Nicholls, Jemma, Melino, Michelle, Nalkurthi, Blessy C, Alexander, Kylie A, Teal, Bianca, Blake, Stephen J, Souza-Fonseca-Guimaraes, Fernando, Engwerda, Christian R, Kuns, Rachel D, Lane, Steven W, Teng, Michele, Teh, Charis, Gray, Daniel, Clouston, Andrew D, Nilsson, Susan K, Blazar, Bruce R, Hill, Geoffrey R, MacDonald, Kelli Pa

“…Regulatory T cells (Tregs) play a crucial role in the maintenance of peripheral tolerance. Quantitative and/or qualitative defects in Tregs result in diseases…”
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Transcriptional Landscape and TCR Diversity of ATA188, a Pre-manufactured, Allogeneic Epstein-Barr Virus-specific T-cell Immunotherapy for Patients with Multiple Sclerosis (MS) (4397) by Foubert, Philippe, Srihari, Sriganesh, Le Texier, Laetitia, Shen, Rhine R., Forozan, Farahnaz, Smith, Corey, Khanna, Rajiv, Aftab, Blake T.

“…Abstract only…”
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Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD by Leveque-El mouttie, Lucie, Koyama, Motoko, Le Texier, Laetitia, Markey, Kate A., Cheong, Melody, Kuns, Rachel D., Lineburg, Katie E., Teal, Bianca E., Alexander, Kylie A., Clouston, Andrew D., Blazar, Bruce R., Hill, Geoffrey R., MacDonald, Kelli P.A.

“…Chronic graft-versus-host disease (cGVHD) is a major cause of late mortality following allogeneic bone marrow transplantation (BMT) and is characterized by…”
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