Search Results - "Le Souef, P. N"

Association between human rhinovirus C and severity of acute asthma in children by Bizzintino, J, Lee, W-M, Laing, I A, Vang, F, Pappas, T, Zhang, G, Martin, A C, Khoo, S-K, Cox, D W, Geelhoed, G C, McMinn, P C, Goldblatt, J, Gern, J E, Le Souëf, P N

“…A new and potentially more pathogenic group of human rhinovirus (HRV), group C (HRVC), has recently been discovered. We hypothesised that HRVC would be present…”
Get full text

The transient value of classifying preschool wheeze into episodic viral wheeze and multiple trigger wheeze by Schultz, A, Devadason, SG, Savenije, OEM, Sly, PD, Le Souëf, PN, Brand, PLP

“…Background:  A recently proposed method for classifying preschool wheeze is to describe it as either episodic (viral) wheeze or multiple trigger wheeze. In…”
Get full text

Lower anti-echovirus antibody responses in children presenting to hospital with asthma exacerbations by Iwasaki, J., Chai, L. Y., Khoo, S.-K., Bizzintino, J., Laing, I. A., Le Souëf, P. N., Thomas, W. R., Hales, B. J.

“…Summary Background Rhinoviruses from the Enterovirus genus cause frequent infections and induce remarkably high titres of anticapsid antigen antibodies in…”
Get full text

Exhaled nitric oxide and asthma: complex interactions between atopy, airway responsiveness, and symptoms in a community population of children by Franklin, P J, Turner, S W, Le Souëf, P N, Stick, S M

“…Background: Exhaled nitric oxide (FENO) is raised in asthmatic children, but there are inconsistencies in the relationship between FENO and characteristics of…”
Get full text

Spacer inhalation technique and deposition of extrafine aerosol in asthmatic children by Roller, C. M, Zhang, G, Troedson, R. G, Leach, C. L, Le Souef, P. N, Devadason, S. G

“…The aim of the present study was to measure airway, oropharyngeal and gastrointestinal deposition of (99m)Tc-labelled hydrofluoroalkane-beclomethasone…”
Get full text

Evolution and respiratory genetics by Le Souef, P. N, Candelaria, P, Goldblatt, J

“…Evolution is a plausible explanation for between-population differences in particular allele frequencies if: the genes involved have related functions; the…”
Get full text

Reduced lung function both before bronchiolitis and at 11 years by Turner, S W, Young, S, Landau, L I, Le Souëf, P N

“…Background and Aims: We have previously shown an association between reduced premorbid lung function (V‘maxFRC) and bronchiolitis. We hypothesised that…”
Get full text

Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy by Zhang, G, Khoo, S.-K, Laatikainen, T, Pekkarinen, P, Vartiainen, E, von Hertzen, L, Hayden, C.M, Goldblatt, J, Mäkelä, M, Haahtela, T, Le Souëf, P.N

“…Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the…”
Get full text

Total IgE in urban Black South African teenagers: The influence of atopy and helminth infection by Levin, M. E., Le Souëf, P. N., Motala, C.

“…Total IgE levels are usually elevated in allergic diseases, being highest in atopic eczema, followed by atopic asthma and allergic rhinitis. Genetic factors…”
Get full text

Cross-sectional and longitudinal association of the secretoglobin 1A1 gene A38G polymorphism with asthma phenotype in the Perth Infant Asthma Follow-up cohort by Laing, I. A., De Klerk, N. H., Turner, S. W., Judge, P. K., Hayden, C. M., Landau, L. I., Goldblatt, J., Le Souëf, P. N.

“…Summary Background Associations between Clara cell secretory protein gene variants (SCGB1A1, also known as CC16, CC10, CCSP and uteroglobin) and the asthma…”
Get full text

A polymorphism of the CC16 gene is associated with an increased risk of asthma by Laing, I A, Goldblatt, J, Eber, E, Hayden, C M, Rye, P J, Gibson, N A, Palmer, L J, Burton, P R, Le Souëf, P N

“…Several quantitative traits associated with the asthma phenotype have been linked to markers on chromosome 11q13, although the gene responsible has yet to be…”
Get full text

Tobacco related lung diseases begin in childhood by Le Souef, P N

Get full text

Rhinovirus and the developing lung by Cox, D.W, Le Souëf, P.N

“…Summary Human rhinovirus (HRV) infections are now widely accepted as the commonest cause of acute respiratory illnesses (ARIs) in children. Advanced PCR…”
Get full text

The importance of environment on respiratory genotype/phenotype relationships in the Inuit by Candelaria, P. V., Backer, V., Khoo, S.‐K., Bizzintino, J. A., Hayden, C. M., Baynam, G., Laing, I. A., Zhang, G., Porsbjerg, C., Goldblatt, J., Le Souëf, P. N.

“…To cite this article: Candelaria PV, Backer V, Khoo S‐K, Bizzintino JA, Hayden CM, Baynam G, Laing IA, Zhang G, Porsbjerg C, Goldblatt J, LeSouëf PN, The…”
Get full text

Determinants of airway responsiveness to histamine in children by Turner, S. W, Palmer, L. J, Rye, P. J, Gibson, N. A, Young, S, Goldblatt, J, Landau, L. I, Le Souef, P. N

“…Increased airway responsiveness (AR) is associated with asthma, but not all individuals with increased AR have asthma. The aim of this study was to identify…”
Get full text

The influence of age on aerosol deposition in children with cystic fibrosis by Chua, HL, Collis, GG, Newbury, AM, Chan, K, Bower, GD, Sly, PD, Le Souef, PN

“…Nebulized aerosols are commonly used to deliver drugs for the treatment of respiratory disease in children, but there are inadequate data on the dose of drug…”
Get full text

Adverse effects of maternal smoking during pregnancy on innate immunity in infants by Le Souëf, P N

Get full text

Factors affecting total and "respirable" dose delivered by a salbutamol metered dose inhaler by Everard, M L, Devadason, S G, Summers, Q A, Le Souëf, P N

“…BACKGROUND--Many factors contribute to the high variability of doses delivered to the lungs of patients using metered dose inhalers (MDIs). Relatively little…”
Get full text

Using twin studies to determine genetic and environmental components of allergy and asthma by Le Soueef, PN

Get full text

A genome-wide search for quantitative trait loci underlying asthma by Daniels, Susan E, Bhattacharrya, Sumit, James, Alan, Leaves, Nicholas I, Young, Alan, Hill, Michael R, Faux, Jennie A, Ryan, Gerrard F, le Söuef, Peter N, Lathrop, G. Mark, Musk, A. William, Cookson, William O. C. M

“…Asthma now affects one child in seven in the United Kingdom. Most cases (95%) of childhood asthma are associated with atopy, the immunoglobulin E…”
Get full text