Search Results - "Le Roux, Karine"
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Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis
Published in Molecular cell (18-06-2015)“…Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, beyond its apoptotic function, is required for the normal expression of major respiratory…”
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Multimodal imaging for tumour characterization from micro‐ to macroscopic level using a newly developed dorsal chamber designed for long‐term follow‐up
Published in Journal of biophotonics (01-01-2020)“…Optical imaging of living animals is a unique method of studying the dynamics of physiological and pathological processes at a subcellular level. One‐shot…”
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Respective Roles of Hematopoietic and Nonhematopoietic Nod2 on the Gut Microbiota and Mucosal Homeostasis
Published in Inflammatory bowel diseases (01-04-2016)“…NOD2 mutations are associated with Crohn's disease (CD). Both CD (in human) and Nod2 deficiency (in mice) are characterized by increased mucosal CD4 T-cells,…”
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Parasites and diet as main drivers of the Malagasy gut microbiome richness and function
Published in Scientific reports (03-09-2021)“…Interactions between the prokaryotic microbiome and eukaryotic parasites in the vertebrate gut may affect overall host health and disease. While intertropical…”
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Identification of NF-κB Modulation Capabilities within Human Intestinal Commensal Bacteria
Published in Journal of biomedicine & biotechnology (01-01-2011)“…The intestinal microbiota plays an important role in modulation of mucosal immune responses. To seek interactions between intestinal epithelial cells (IEC) and…”
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Granulomatous myositis: A clinical study of thirteen cases
Published in Muscle & nerve (01-02-2007)“…Granulomatous myositis (GM) is a rare condition that has generally been described in association with sarcoidosis. In the absence of sarcoidosis or other…”
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The clinical Pseudomonas fluorescens MFN1032 strain exerts a cytotoxic effect on epithelial intestinal cells and induces Interleukin-8 via the AP-1 signaling pathway
Published in BMC microbiology (10-08-2010)“…Pseudomonas fluorescens is present in low number in the intestinal lumen and has been proposed to play a role in Crohn's disease (CD). Indeed, a highly…”
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Granulomatous myositis: characteristics and outcome from a monocentric retrospective cohort study
Published in Neuromuscular disorders : NMD (01-09-2024)“…•Granulomatous myositis is a severe and difficult to treat disease in which distal motor deficit and clinical amyotrophy seem to be predictive factors for…”
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Modulation of the microbiota by oral antibiotics treats immunoglobulin A nephropathy in humanized mice
Published in Nephrology, dialysis, transplantation (01-07-2019)“…Abstract Background Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. IgA is mainly produced by the gut-associated…”
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A Guide for Ex Vivo Handling and Storage of Stool Samples Intended for Fecal Microbiota Transplantation
Published in Scientific reports (20-06-2019)“…Owing to the growing recognition of the gut microbiota as a main partner of human health, we are expecting that the number of indications for fecal microbiota…”
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Assessment of Neonatal Intensive Care Unit Practices and Preterm Newborn Gut Microbiota and 2-Year Neurodevelopmental Outcomes
Published in JAMA network open (01-09-2020)“…In very preterm newborns, gut microbiota is highly variable with major dysbiosis. Its association with short-term health is widely studied, but the association…”
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Altered gut microbiota composition in immune-impaired Nod2(-/-) mice
Published in Gut (01-04-2012)Get more information
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Nod2 Deficiency Leads to a Specific and Transmissible Mucosa-associated Microbial Dysbiosis Which Is Independent of the Mucosal Barrier Defect
Published in Journal of Crohn's and colitis (01-12-2016)“…Abstract Background and Aims: Crohn’s disease [CD] is a complex disorder characterised by an inappropriate immune response, impaired barrier function and…”
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Butyrate produced by commensal bacteria potentiates phorbol esters induced AP-1 response in human intestinal epithelial cells
Published in PloS one (27-12-2012)“…The human intestine is a balanced ecosystem well suited for bacterial survival, colonization and growth, which has evolved to be beneficial both for the host…”
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DiPRO1 distinctly reprograms muscle and mesenchymal cancer cells
Published in EMBO molecular medicine (15-07-2024)“…We have recently identified the uncharacterized ZNF555 protein as a component of a productive complex involved in the morbid function of the 4qA locus in…”
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Endothelial and hematopoietic hPSCs differentiation via a hematoendothelial progenitor
Published in Stem cell research & therapy (17-06-2022)“…Background hPSC-derived endothelial and hematopoietic cells (ECs and HCs) are an interesting source of cells for tissue engineering. Despite their close…”
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Cord blood-endothelial colony forming cells are immunotolerated and participate at post-ischemic angiogenesis in an original dorsal chamber immunocompetent mouse model
Published in Stem cell research & therapy (07-05-2020)“…Cardiovascular diseases are the main cause of morbidity and mortality worldwide. Restoring blood supply to ischemic tissues is an essential goal for the…”
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Pickering emulsions with ethiodized oil and nanoparticles for slow release of intratumoral anti-CTLA4 immune checkpoint antibodies
Published in Journal for immunotherapy of cancer (01-06-2020)“…BackgroundIntratumorous immunotherapy for cancer is currently thriving. The aim of such local strategy is to improve the therapeutic index of these treatments,…”
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Intrathecal Synthesis of Immunoglobulins in Patients with Unexplained Intermediate Uveitis
Published in Ocular immunology and inflammation (01-02-2011)“…Purpose: To assess the value of lumbar punctures in adult patients with unexplained intermediate uveitis (IU). Methods: Retrospective study of 17 patients with…”
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