Search Results - "Le Roux, Carel W."
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Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation
Published in Cell metabolism (04-08-2015)“…Bariatric surgery is currently the most effective procedure for the treatment of obesity. Given the role of the gut microbiota in regulating host metabolism…”
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A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management
Published in The New England journal of medicine (02-07-2015)“…This trial compared once-daily liraglutide, a glucagon-like peptide-1 analogue, with placebo in overweight or obese patients. Liraglutide was associated with…”
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The Road towards Triple Agonists: Glucagon-Like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide and Glucagon Receptor - An Update
Published in Endocrinology and metabolism (Seoul) (01-02-2024)“…Obesity is the fifth leading risk factor for global deaths with numbers continuing to increase worldwide. In the last 20 years, the emergence of…”
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Weight Loss, Satiety, and the Postprandial Gut Hormone Response After Esophagectomy: A Prospective Study
Published in Annals of surgery (01-07-2017)“…OBJECTIVE:To prospectively characterize changes in body weight, satiety, and postprandial gut hormone profiles following esophagectomy. BACKGROUND:With…”
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Amylin as a Future Obesity Treatment
Published in Journal of Obesity & Metabolic Syndrome (01-12-2021)“…Obesity is defined as abnormal or excessive fat accumulation that contributes to detrimental health impacts. One-third of the population suffers from obesity,…”
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Weight loss to disrupt type 2 diabetes
Published in Diabetology international (01-07-2023)“…Obesity is now recognised as a disease associated with significant morbidity and mortality. One of the most common metabolic complications of obesity is type 2…”
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Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters
Published in Annals of surgery (2006)“…To study the effect of bariatric surgery on the entero-hypothalamic endocrine axis of humans and rodents. Bariatric surgery is the most effective obesity…”
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Increased postprandial energy expenditure may explain superior long term weight loss after Roux-en-Y gastric bypass compared to vertical banded gastroplasty
Published in PloS one (03-04-2013)“…Gastric bypass results in greater weight loss than Vertical banded gastroplasty (VBG), but the underlying mechanisms remain unclear. In addition to effects on…”
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Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices
Published in Scientific reports (18-05-2022)“…To establish whether obesity involves activation of endogenous ciliary neurotrophic factor (CNTF) signalling, we evaluated its plasma levels in patients with…”
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Effect of the Natural Sweetener Xylitol on Gut Hormone Secretion and Gastric Emptying in Humans: A Pilot Dose-Ranging Study
Published in Nutrients (01-01-2021)“…Sugar consumption is associated with a whole range of negative health effects and should be reduced and the natural sweetener xylitol might be helpful in…”
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Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake
Published in PloS one (22-06-2015)“…The mechanisms determining long-term weight maintenance after Roux-en-Y gastric bypass (RYGB) remain unclear. Cross sectional studies have suggested that…”
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Bariatric surgery for the treatment of chronic kidney disease in obesity and type 2 diabetes mellitus
Published in Nature reviews. Nephrology (01-12-2020)“…Bariatric surgery is an effective therapy for obesity, hypertension and type 2 diabetes mellitus that is refractory to maximal medical therapy. Results of…”
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A Fatty Diet Induces a Jejunal Ketogenesis Which Inhibits Local SGLT1-Based Glucose Transport via an Acetylation Mechanism-Results from a Randomized Cross-Over Study between Iso-Caloric High-Fat versus High-Carbohydrate Diets in Healthy Volunteers
Published in Nutrients (07-05-2022)“…Insights into the nature of gut adaptation after different diets enhance the understanding of how food modifications can be used to treat type 2 diabetes and…”
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Mechanisms of Weight Loss After Obesity Surgery
Published in Endocrine reviews (01-02-2022)“…Abstract Obesity surgery remains the most effective treatment for obesity and its complications. Weight loss was initially attributed to decreased energy…”
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Do Gut Hormones Contribute to Weight Loss and Glycaemic Outcomes after Bariatric Surgery?
Published in Nutrients (26-02-2021)“…Bariatric surgery is an effective intervention for management of obesity through treating dysregulated appetite and achieving long-term weight loss…”
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Review of multimodal treatment for type 2 diabetes: combining metabolic surgery and pharmacotherapy
Published in Therapeutic Advances in Endocrinology and Metabolism (2019)“…Treating type 2 diabetes mellitus (T2DM) in patients with obesity remains a challenge for physicians, endocrinologists and surgeons, a fact supported by…”
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Mechanisms underlying weight loss after bariatric surgery
Published in Nature reviews. Gastroenterology & hepatology (01-10-2013)“…Bariatric surgery is an effective treatment for obesity, providing long-term maintenance of weight loss. Here, the authors discuss the various mechanisms by…”
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Changes in gut hormone profile and glucose homeostasis after laparoscopic sleeve gastrectomy
Published in Surgery for obesity and related diseases (01-03-2013)“…Abstract Background Changes in glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) levels after bariatric surgery have been proposed as a mechanism for…”
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COVID-19 alters thinking and management in metabolic diseases
Published in Nature reviews. Endocrinology (01-02-2021)“…Metabolic diseases emerged as important risk factors for severe COVID-19, but the mechanisms responsible remained unclear for some time. The severity of…”
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Consensus Report: Definition and Interpretation of Remission in Type 2 Diabetes
Published in Diabetes care (30-08-2021)“…Improvement of glucose levels into the normal range can occur in some people living with diabetes, either spontaneously or after medical interventions, and in…”
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