Search Results - "Le Poul, Emmanuel"

Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression by Campo, Brice, Kalinichev, Mikhail, Lambeng, Nathalie, Yacoubi, M. El, Royer-Urios, Isabelle, Schneider, Manfred, Legrand, Coline, Parron, Delphine, Girard, Francoise, Bessif, Abdelhak, Poli, Sonia, Vaugeois, Jean-Marie, Poul, Emmanuel Le, Celanire, Sylvain

“…There is growing evidence suggesting that antagonists of group II metabotropic glutamate receptors (mGluR2/3) exhibit antidepressant-like properties in several…”
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ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization by Kalinichev, Mikhail, Rouillier, Mélanie, Girard, Francoise, Royer-Urios, Isabelle, Bournique, Bruno, Finn, Terry, Charvin, Delphine, Campo, Brice, Le Poul, Emmanuel, Mutel, Vincent, Poli, Sonia, Neale, Stuart A, Salt, Thomas E, Lütjens, Robert

“…Metabotropic glutamate receptor 7 (mGlu(7)) has been suggested to be a promising novel target for treatment of a range of disorders, including anxiety,…”
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Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation by Le Poul, Emmanuel, Loison, Cécile, Struyf, Sofie, Springael, Jean-Yves, Lannoy, Vincent, Decobecq, Marie-Eve, Brezillon, Stéphane, Dupriez, Vincent, Vassart, Gilbert, Van Damme, Jo, Parmentier, Marc, Detheux, Michel

“…Short chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are produced at high concentration by bacteria in the gut and subsequently…”
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Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids by Wittamer, Valérie, Franssen, Jean-Denis, Vulcano, Marisa, Mirjolet, Jean-François, Le Poul, Emmanuel, Migeotte, Isabelle, Brézillon, Stéphane, Tyldesley, Richard, Blanpain, Cédric, Detheux, Michel, Mantovani, Alberto, Sozzani, Silvano, Vassart, Gilbert, Parmentier, Marc, Communi, David

“…Dendritic cells (DCs) and macrophages are professional antigen-presenting cells (APCs) that play key roles in both innate and adaptive immunity. ChemR23 is an…”
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The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54 by Kotani, Masato, Detheux, Michel, Vandenbogaerde, Ann, Communi, David, Vanderwinden, Jean-Marie, Le Poul, Emmanuel, Brézillon, Stéphane, Tyldesley, Richard, Suarez-Huerta, Nathalie, Vandeput, Fabrice, Blanpain, Cédric, Schiffmann, Serge N., Vassart, Gilbert, Parmentier, Marc

“…Natural peptides displaying agonist activity on the orphan G protein-coupled receptor GPR54 were isolated from human placenta. These 54-, 14,- and 13-amino…”
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Pharmacological characterization of the human P2Y13 receptor by Marteau, Frederic, Le Poul, Emmanuel, Communi, David, Communi, Didier, Labouret, Catherine, Savi, Pierre, Boeynaems, Jean-Marie, Gonzalez, Nathalie Suarez

“…The P2Y13 receptor has recently been identified as a new P2Y receptor sharing a high sequence homology with the P2Y12 receptor as well as similar functional…”
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mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents by Rocher, Jean-Philippe, Bonnet, Béatrice, Boléa, Christelle, Lütjens, Robert, Le Poul, Emmanuel, Poli, Sonia, Epping-Jordan, Mark, Bessis, Anne-Sophie, Ludwig, Bernard, Mutel, Vincent

“…Allosteric modulators of metabotropic glutamate receptors (mGluR) subtypes 1-8 have been shown to offer a valid way to develop small molecule non…”
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Supersensitivity of human metabotropic glutamate 1a receptor signaling in L929sA cells by Lavreysen, Hilde, Le Poul, Emmanuel, Van Gompel, Paul, Dillen, Lieve, Leysen, Josée E, Lesage, Anne S J

“…The effect of antagonist pretreatment on the signaling properties of the human metabotropic glutamate 1a (hmGlu1a) receptor was examined in stably transfected…”
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Pharmacological and pharmacokinetic properties of JNJ‐40411813, a positive allosteric modulator of the mGlu2 receptor by Lavreysen, Hilde, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Langlois, Xavier, Mackie, Claire, Pype, Stefan, Lütjens, Robert, Le Poul, Emmanuel, Trabanco, Andrés A., Nuñez, José María Cid

“…Compounds modulating metabotropic glutamate type 2 (mGlu2) receptor activity may have therapeutic benefits in treating psychiatric disorders like schizophrenia…”
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Identification of Natural Ligands for the Orphan G Protein-coupled Receptors GPR7 and GPR8 by Brezillon, Stéphane, Lannoy, Vincent, Franssen, Jean-Denis, Le Poul, Emmanuel, Dupriez, Vincent, Lucchetti, Jean, Detheux, Michel, Parmentier, Marc

“…GPR7 and GPR8 are two structurally related orphan G protein-coupled receptors, presenting high similarities with opioid and somatostatin receptors. Two…”
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Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis by Lagane, Bernard, Ballet, Sébastien, Planchenault, Thierry, Balabanian, Karl, Le Poul, Emmanuel, Blanpain, Cédric, Percherancier, Yann, Staropoli, Isabelle, Vassart, Gilbert, Oppermann, Martin, Parmentier, Marc, Bachelerie, Françoise

“…CC chemokine receptor 5 (CCR5) is a G protein-coupled receptor that governs migration of leukocytes and serves as a coreceptor for the R5 tropic strains of…”
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New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones by Trabanco, Andrés A., Duvey, Guillaume, Cid, José María, Macdonald, Gregor J., Cluzeau, Philippe, Nhem, Vanthea, Furnari, Rocco, Behaj, Nadia, Poulain, Géraldine, Finn, Terry, Lavreysen, Hilde, Poli, Sonia, Raux, Alexandre, Thollon, Yves, Poirier, Nicolas, D’Addona, David, Andrés, José Ignacio, Lutjens, Robert, Poul, Emmanuel Le, Imogai, Hassan, Rocher, Jean-Philippe

“…A series of N-propyl-8-chloro-6-substituted isoquinolones was identified as positive allosteric modulators of metabotropic glutamate receptor 2 (mGluR2 PAM)…”
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Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies by Blanpain, Cédric, Vanderwinden, Jean-Marie, Cihak, Josef, Wittamer, Valérie, Le Poul, Emmanuel, Issafras, Hassan, Stangassinger, Manfred, Vassart, Gilbert, Marullo, Stefano, Schlndorff, Detlef, Parmentier, Marc, Mack, Matthias

“…CC-chemokine receptor 5 (CCR5) is the principal coreceptor for macrophage-tropic strains of human immunodeficiency virus type 1 (HIV-1). We have generated a…”
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Functional characterization of a human receptor for neuropeptide FF and related peptides by Kotani, Masato, Mollereau, Catherine, Detheux, Michel, Le Poul, Emmanuel, Brézillon, Stéphane, Vakili, Jalal, Mazarguil, Honoré, Vassart, Gilbert, Zajac, Jean‐Marie, Parmentier, Marc

“…Neuropeptides FF (NPFF) and AF (NPAF) are involved in pain modulation and opioid tolerance. These peptides were known to act through uncharacterized G…”
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Activation of CCR5 by Chemokines Involves an Aromatic Cluster between Transmembrane Helices 2 and 3 by Govaerts, Cédric, Bondue, Antoine, Springael, Jean-Yves, Olivella, Mireia, Deupi, Xavier, Le Poul, Emmanuel, Wodak, Shoshana J., Parmentier, Marc, Pardo, Leonardo, Blanpain, Cédric

“…CCR5 is a G protein-coupled receptor responding to four natural agonists, the chemokines RANTES (regulated on activation normal T cell expressed and secreted),…”
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Palmitoylation of CCR5 Is Critical for Receptor Trafficking and Efficient Activation of Intracellular Signaling Pathways by Blanpain, Cédric, Wittamer, Valérie, Vanderwinden, Jean-Marie, Boom, Alain, Renneboog, Benoı̂t, Lee, Benhur, Le Poul, Emmanuel, El Asmar, Laı̈la, Govaerts, Cédric, Vassart, Gilbert, Doms, Robert W., Parmentier, Marc

“…CCR5 is a CC chemokine receptor expressed on memory lymphocytes, macrophages, and dendritic cells and also constitutes the main coreceptor for…”
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Aequorin-based functional assays for G-protein-coupled receptors, ion channels, and tyrosine kinase receptors by Dupriez, Vincent J, Maes, Karlien, Le Poul, Emmanuel, Burgeon, Emmanuel, Detheux, Michel

“…Aequorin is a photoprotein originating from jellyfish, whose luminescent activity is dependent on the concentration of calcium ions. Due to the high…”
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A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease by Le Poul, Emmanuel, Boléa, Christelle, Girard, Francoise, Poli, Sonia, Charvin, Delphine, Campo, Brice, Bortoli, Julien, Bessif, Abdhelak, Luo, Bin, Koser, Amy Jo, Hodge, Lisa M, Smith, Karen M, DiLella, Anthony G, Liverton, Nigel, Hess, Fred, Browne, Susan E, Reynolds, Ian J

“…Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 4 (mGluR4) have been proposed as a novel therapeutic approach for the treatment of…”
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Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders by Kalinichev, Mikhail, Le Poul, Emmanuel, Boléa, Christelle, Girard, Françoise, Campo, Brice, Fonsi, Massimiliano, Royer-Urios, Isabelle, Browne, Susan E, Uslaner, Jason M, Davis, Matthew J, Raber, Jacob, Duvoisin, Robert, Bate, Simon T, Reynolds, Ian J, Poli, Sonia, Celanire, Sylvain

“…There is growing evidence that activation of metabotropic glutamate receptor 4 (mGlu4) leads to anxiolytic- and antipsychotic-like efficacy in rodent models,…”
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A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core by Duvey, Guillaume, Perry, Benjamin, Le Poul, Emmanuel, Poli, Sonia, Bonnet, Beatrice, Lambeng, Nathalie, Charvin, Delphine, Donovan-Rodrigues, Tansy, Haddouk, Hasnaà, Gagliardi, Stefania, Rocher, Jean-Philippe

“…A series of potent non-acetylinic negative allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5 NAMs) was developed starting from HTS…”
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