Search Results - "Le Naour, Morgan"

Bivalent Ligands That Target μ Opioid (MOP) and Cannabinoid1 (CB1) Receptors Are Potent Analgesics Devoid of Tolerance by Le Naour, Morgan, Akgün, Eyup, Yekkirala, Ajay, Lunzer, Mary M, Powers, Mike D, Kalyuzhny, Alexander E, Portoghese, Philip S

“…Given that μ opioid (MOP) and canabinoid (CB1) receptors are colocalized in various regions of the central nervous system and have been reported to associate…”
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Putative Kappa Opioid Heteromers As Targets for Developing Analgesics Free of Adverse Effects by Le Naour, Morgan, Lunzer, Mary M, Powers, Michael D, Kalyuzhny, Alexander E, Benneyworth, Michael A, Thomas, Mark J, Portoghese, Philip S

“…It is now generally recognized that upon activation by an agonist, β-arrestin associates with G protein-coupled receptors and acts as a scaffold in creating a…”
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Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists by Hurtevent, Aurélie, Le Naour, Morgan, Leclerc, Veronique, Carato, Pascal, Melnyk, Patricia, Hennuyer, Nathalie, Staels, Bart, Beucher-Gaudin, Monique, Caignard, Daniel-Henri, Dacquet, Catherine, Lebegue, Nicolas

“…A series of nitrogen heterocycles containing α-ethoxyphenylpropionic acid derivatives were designed as dual PPARα/γ agonist ligands for the treatment of type 2…”
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Effect of Oxime Ether Incorporation in Acyl Indole Derivatives on PPAR Subtype Selectivity by Le Naour, Morgan, Leclerc, Veronique, Farce, Amaury, Caignard, Daniel-Henri, Hennuyer, Nathalie, Staels, Bart, Audinot-Bouchez, Valérie, Boutin, Jean-Albert, Lonchampt, Michel, Dacquet, Catherine, Ktorza, Alain, Berthelot, Pascal, Lebegue, Nicolas

“…Compounds that simultaneously activate peroxisome proliferator‐activated receptor (PPAR) subtypes α and γ have the potential to effectively treat dyslipidemia…”
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A Fentanyl Vaccine Alters Fentanyl Distribution and Protects against Fentanyl-Induced Effects in Mice and Rats by Raleigh, Michael D, Baruffaldi, Federico, Peterson, Samantha J, Le Naour, Morgan, Harmon, Theresa M, Vigliaturo, Jennifer R, Pentel, Paul R, Pravetoni, Marco

“…Fentanyl is an extremely potent synthetic opioid that has been increasingly used to adulterate heroin, cocaine, and counterfeit prescription pills, leading to…”
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Reduced Antinociception of Opioids in Rats and Mice by Vaccination with Immunogens Containing Oxycodone and Hydrocodone Haptens by Pravetoni, Marco, Le Naour, Morgan, Tucker, Ashli M, Harmon, Theresa M, Hawley, Tara M, Portoghese, Philip S, Pentel, Paul R

“…Prescription opioids abuse and associated deaths are an emerging concern in the USA. Vaccination against prescription opioids may provide an alternative to…”
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Opioid Activity of Spinally Selective Analogues of N-Naphthoyl-β-naltrexamine in HEK-293 Cells and Mice by Le Naour, Morgan, Lunzer, Mary M, Powers, Mike D, Portoghese, Philip S

“…Using the selective mu–kappa agonist, N-naphthoyl-β-naltrexamine 1, as the prototype ligand, a series of closely related naphthalene analogues were synthesized…”
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