Search Results - "Le Naour, Francois"

In Situ Lipidomic Analysis of Nonalcoholic Fatty Liver by Cluster TOF-SIMS Imaging by Debois, Delphine, Bralet, Marie-Pierre, Le Naour, François, Brunelle, Alain, Laprévote, Olivier

“…Mass spectrometry imaging has been used to map liver biopsies of several patients suffering from nonalcoholic fatty liver disease. This steatosis is…”
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E-Cadherin/p120-Catenin and Tetraspanin Co-029 Cooperate for Cell Motility Control in Human Colon Carcinoma by GRECO, Céline, BRALET, Marie-Pierre, AILANE, Naouel, DUBART-KUPPERSCHMITT, Anne, RUBINSTEIN, Eric, LE NAOUR, François, BOUCHEIX, Claude

“…Tumor invasion and metastasis are major obstacles to clinical treatment that rely on cell migration. Here, we elucidate a mechanism of colon carcinoma cell…”
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The tetraspanins CD9 and CD81 regulate CD9P1-induced effects on cell migration by Chambrion, Célia, Le Naour, François

“…CD9P-1 is a cell surface protein with immunoglobulin domains and an unknown function that specifically associates with tetraspanins CD9 and CD81…”
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A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44 by Stoeck, Alexander, Keller, Sascha, Riedle, Svenja, Sanderson, Michael P, Runz, Steffen, Le Naour, Francois, Gutwein, Paul, Ludwig, Andreas, Rubinstein, Eric, Altevogt, Peter

“…Ectodomain shedding is a proteolytic mechanism by which transmembrane molecules are converted into a soluble form. Cleavage is mediated by metalloproteases and…”
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The tumor antigen EpCAM: tetraspanins and the tight junction protein claudin-7, new partners, new functions by Le Naour, Francois, Zoller, Margot

“…The cell-cell adhesion molecule EpCAM/CD326 has been one of the first tumor-associated antigens and has soon received attention as an antibody target in cancer…”
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Separation of peptides from detergents using ion mobility spectrometry by Bagag, Aïcha, Giuliani, Alexandre, Canon, Francis, Réfrégiers, Matthieu, Naour, François Le

“…Mass spectrometry (MS) has dramatically evolved in the last two decades and has been the driving force of the spectacular expansion of proteomics during this…”
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Lateral organization of membrane proteins: tetraspanins spin their web by Charrin, Stéphanie, le Naour, François, Silvie, Olivier, Milhiet, Pierre-Emmanuel, Boucheix, Claude, Rubinstein, Eric

“…Despite high expression levels at the plasma membrane or in intracellular vesicles, tetraspanins remain among the most mysterious transmembrane molecules 20…”
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Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients by Chiappini, Franck, Coilly, Audrey, Kadar, Hanane, Gual, Philippe, Tran, Albert, Desterke, Christophe, Samuel, Didier, Duclos-Vallée, Jean-Charles, Touboul, David, Bertrand-Michel, Justine, Brunelle, Alain, Guettier, Catherine, Le Naour, François

“…Nonalcoholic steatohepatitis (NASH) is a condition which can progress to cirrhosis and hepatocellular carcinoma. Markers for NASH diagnosis are still lacking…”
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Tetraspanins Regulate ADAM10-Mediated Cleavage of TNF-{alpha} and Epidermal Growth Factor by Arduise, Cecile, Abache, Toufik, Li, Lei, Billard, Martine, Chabanon, Aurelie, Ludwig, Andreas, Mauduit, Philippe, Boucheix, Claude, Rubinstein, Eric, Le Naour, Francois

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HRas Signal Transduction Promotes Hepatitis C Virus Cell Entry by Triggering Assembly of the Host Tetraspanin Receptor Complex by Zona, Laetitia, Lupberger, Joachim, Sidahmed-Adrar, Nazha, Thumann, Christine, Harris, Helen J., Barnes, Amy, Florentin, Jonathan, Tawar, Rajiv G., Xiao, Fei, Turek, Marine, Durand, Sarah C., Duong, François H.T., Heim, Markus H., Cosset, François-Loïc, Hirsch, Ivan, Samuel, Didier, Brino, Laurent, Zeisel, Mirjam B., Le Naour, François, McKeating, Jane A., Baumert, Thomas F.

“…Hepatitis C virus (HCV) entry is dependent on coreceptor complex formation between the tetraspanin superfamily member CD81 and the tight junction protein…”
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Severely Reduced Female Fertility in CD9-Deficient Mice by Le Naour, François, Rubinstein, Eric, Jasmin, Claude, Prenant, Michel, Boucheix, Claude

“…CD9 is a widely expressed cell surface molecule that belongs to the tetraspanin superfamily of proteins. The tetraspanins CD9, KAI-1/CD82, and CD63 are…”
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Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans by Tam, Jenny M, Reedy, Jennifer L, Lukason, Daniel P, Kuna, Sunnie G, Acharya, Mridu, Khan, Nida S, Negoro, Paige E, Xu, Shuying, Ward, Rebecca A, Feldman, Michael B, Dutko, Richard A, Jeffery, Jane B, Sokolovska, Anna, Wivagg, Carl N, Lassen, Kara G, Le Naour, François, Matzaraki, Vasiliki, Garner, Ethan C, Xavier, Ramnik J, Kumar, Vinod, van de Veerdonk, Frank L, Netea, Mihai G, Miranti, Cindy K, Mansour, Michael K, Vyas, Jatin M

“…Tetraspanins are a family of proteins possessing four transmembrane domains that help in lateral organization of plasma membrane proteins. These proteins…”
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Tspan15 Is a New Stemness‐Related Marker in Hepatocellular Carcinoma by Sidahmed‐Adrar, Nazha, Ottavi, Jean‐François, Benzoubir, Nassima, Ait Saadi, Taous, Bou Saleh, Mohamed, Mauduit, Philippe, Guettier, Catherine, Desterke, Christophe, Le Naour, François

“…Hepatocellular carcinoma (HCC) is the second cause of cancer‐related deaths worldwide. A clearer understanding of the molecular mechanisms underlying tumor…”
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Global Profiling of the Cell Surface Proteome of Cancer Cells Uncovers an Abundance of Proteins with Chaperone Function by Shin, Bong Kyung, Wang, Hong, Yim, Anne Marie, Le Naour, Francois, Brichory, Franck, Jang, Jun Ho, Zhao, Rong, Puravs, Eric, Tra, John, Michael, Claire W, Misek, David E, Hanash, Samir M

“…There is currently limited data available pertaining to the global characterization of the cell surface proteome. We have implemented a strategy for the…”
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Discrimination of cirrhotic nodules, dysplastic lesions and hepatocellular carcinoma by their vibrational signature by Peng, Chengyuan, Kaščáková, Slávka, Chiappini, Franck, Olaya, Natalia, Sandt, Christophe, Yousef, Ibraheem, Samuel, Didier, Dumas, Paul, Guettier, Catherine, Le Naour, François

“…Hepatocarcinogenesis is a multistep process characterized in patients with chronic liver diseases by a spectrum of hepatic nodules that mark the progression…”
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Multimodal Spectroscopy Combining Time-of-Flight-Secondary Ion Mass Spectrometry, Synchrotron-FT-IR, and Synchrotron-UV Microspectroscopies on the Same Tissue Section by Petit, Vanessa W, Réfrégiers, Matthieu, Guettier, Catherine, Jamme, Frédéric, Sebanayakam, Kumaraparithy, Brunelle, Alain, Laprévote, Olivier, Dumas, Paul, Le Naour, François

“…Mass spectrometry and spectroscopy-based approaches can provide an overview of the chemical composition of a tissue sample. This opens up the possibility to…”
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In Situ Chemical Composition Analysis of Cirrhosis by Combining Synchrotron Fourier Transform Infrared and Synchrotron X‑ray Fluorescence Microspectroscopies on the Same Tissue Section by Le Naour, François, Sandt, Christophe, Peng, Chengyuan, Trcera, Nicolas, Chiappini, Franck, Flank, Anne-Marie, Guettier, Catherine, Dumas, Paul

“…Liver is subject to various chronic pathologies, progressively leading to cirrhosis, which is associated with an increased risk of hepatocellular carcinoma…”
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Characterization of hydrophobic peptides in the presence of detergent by photoionization mass spectrometry by Bagag, Aïcha, Jault, Jean-Michel, Sidahmed-Adrar, Nazha, Réfrégiers, Matthieu, Giuliani, Alexandre, Le Naour, François

“…The characterization of membrane proteins is still challenging. The major issue is the high hydrophobicity of membrane proteins that necessitates the use of…”
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Chemical imaging on liver steatosis using synchrotron infrared and ToF-SIMS microspectroscopies by Le Naour, François, Bralet, Marie-Pierre, Debois, Delphine, Sandt, Christophe, Guettier, Catherine, Dumas, Paul, Brunelle, Alain, Laprévote, Olivier

“…Fatty liver or steatosis is a frequent histopathological change. It is a precursor for steatohepatitis that may progress to cirrhosis and in some cases to…”
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The CD81 partner EWI-2wint inhibits hepatitis C virus entry by Rocha-Perugini, Vera, Montpellier, Claire, Delgrange, David, Wychowski, Czeslaw, Helle, François, Pillez, André, Drobecq, Hervé, Le Naour, François, Charrin, Stéphanie, Levy, Shoshana, Rubinstein, Eric, Dubuisson, Jean, Cocquerel, Laurence

“…Two to three percent of the world's population is chronically infected with hepatitis C virus (HCV) and thus at risk of developing liver cancer. Although…”
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