Search Results - "Le Moal, M L"

Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons by Piazza, P V, Le Moal, M L

“…Research on drug abuse has recently focused on understanding the vulnerability to develop addiction that is present in certain individuals. These…”
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Mesocorticolimbic dopaminergic network: functional and regulatory roles by Le Moal, M, Simon, H

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8-OH-DPAT, a 5-HT1A agonist and ritanserin, a 5-HT2A/C antagonist, reverse haloperidol-induced catalepsy in rats independently of striatal dopamine release by LUCAS, G, BONHOMME, N, DE DEURWAERDERE, P, LE MOAL, M, SPAMPINATO, U

“…In this study, both catalepsy and changes in extracellular levels of striatal dopamine (DA) and dihydroxyphenyl acetic acid (DOPAC) induced by the typical…”
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Extension of a New Two-Trial Memory Task in the Rat: Influence of Environmental Context on Recognition Processes by Dellu, F., Fauchey, V., Moal, M.Le, Simon, H.

“…A two-trial memory task, based on place or object exploration in a Y-maze, was developed to study recognition processes in young and aged Sprague–Dawley rats…”
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Inhibition of corticosterone synthesis by Metyrapone decreases cocaine-induced locomotion and relapse of cocaine self-administration by Piazza, P V, Marinelli, M, Jodogne, C, Deroche, V, Rougé-Pont, F, Maccari, S, Le Moal, M, Simon, H

“…Several studies have recently shown that basal and stress-induced secretion of corticosterone may enhance vulnerability to drugs of abuse. In this report, we…”
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Stress-induced sensitization to amphetamine and morphine psychomotor effects depend on stress-induced corticosterone secretion by Deroche, V, Piazza, P V, Casolini, P, Maccari, S, Le Moal, M, Simon, H

“…Repeated exposure to stressful situations has been shown to increase individual reactivity to addictive drugs. However, the biological factors involved in such…”
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Higher and longer stress-induced increase in dopamine concentrations in the nucleus accumbens of animals predisposed to amphetamine self-administration. A microdialysis study by Rougé-Pont, F, Piazza, P V, Kharouby, M, Le Moal, M, Simon, H

“…Individual vulnerability to the reinforcing effects of drugs appears to be a crucial factor in the development of addiction in humans. In the rat, individuals…”
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Relationships between individual sensitivity to CS- and cocaine-induced reinstatement in the rat: Special issue on reinstatement - toward a model of relapse by DEROCHE-GAMONET, V, MARTINEZ, A, LE MOAL, M, PIAZZA, P. V

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Acute pharmacological blockade of corticosterone secretion reverses food restriction-induced sensitization of the locomotor response to cocaine by Marinelli, Michela, Le Moal, Michel, Piazza, Pier Vincenzo

“…Several data indicate that a blockade of stress-induced corticosterone secretion prevents the development of the stress-induced sensitization of the behavioral…”
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Serotonin enhances striatal dopamine outflow in vivo through dopamine uptake sites by De Deurwaerdère, P, Bonhomme, N, Lucas, G, Le Moal, M, Spampinato, U

“…Serotonin (5-HT) administered at 1, 3, and 10 microM into the striatum of halothane-anesthetized rats by in vivo microdialysis increased extracellular dopamine…”
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Opponent process theory of motivation: neurobiological evidence from studies of opiate dependence by Koob, G F, Stinus, L, Le Moal, M, Bloom, F E

“…One hypothetical model for a mechanism of drug dependence involves the development of an adaptive process that is initiated to counter the acute effects of the…”
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Effect of aging on the basal expression of c-fos, c-jun, and egr-1 proteins in the hippocampus by Desjardins, S., Mayo, W., Vallée, M., Hancock, D., Le Moal, M., Simon, H., Abrous, D.N.

“…In the present study the effect of aging on the basal expression of three different immediate early genes (IEGs) was investigated. The protein products of c-…”
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Social deprivation enhances the vulnerability of male Wistar rats to stressor- and amphetamine-induced behavioral sensitization by AHMED, S. H, STINUS, L, LE MOAL, M, CADOR, M

“…The aim of the present study was to assess the influence of experiential factors on the vulnerability of rats to develop amphetamine (AMPH)- and…”
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Individual differences in the psychomotor effects of morphine are predicted by reactivity to novelty and influenced by corticosterone secretion by Deroche, V, Piazza, P V, Le Moal, M, Simon, H

“…Clinical observations show that individual vulnerability to the reinforcing properties of drugs plays an important part in the subsequent development of…”
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Behavioral reactivity to novelty during youth as a predictive factor of stress-induced corticosterone secretion in the elderly—a life-span study in rats by Dellu, F., Mayo, W., Vallée, M., Maccari, S., Piazza, P.V., Le Moal, M., Simon, H.

“…Inter- and intea-individual differences in hypothalamo-pituitary adrenal (HPA) axis activity and behavioral reactivity to novelty between young and old rats…”
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Reactivity to novelty during youth as a predictive factor of cognitive impairment in the elderly: a longitudinal study in rats by Dellu, F, Mayo, W, Vallée, M, Le Moal, M, Simon, H

“…A life-span study of certain behavioral traits was conducted in rats. Animals were repeatedly tested in a circular corridor for reactivity to novelty and in a…”
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Rats orally self-administer corticosterone by Deroche, V, Piazza, P V, Deminière, J M, Le Moal, M, Simon, H

“…Corticosterone, the major glucocorticoid in the rat, may modulate the reinforcing properties of addictive drugs as well as act as a positive reinforcer for…”
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Interaction between endogenous opioids and dopamine within the nucleus accumbens by Stinus, L, Cador, M, Le Moal, M

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Septal vasopressin modulates social memory in male rats by Dantzer, R, Koob, G F, Bluthé, R M, Le Moal, M

“…Adult male rats that are confronted with a sexually immature conspecific display a dramatic reduction in investigatory behavior upon re-exposure to the same…”
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Biphasic effect on nociception and antiopiate activity of the neuropeptide FF (FLFQPQRFamide) in the rat by Oberling, P, Stinus, L, Le Moal, M, Simonnet, G

“…The purpose of the present study was to systematically investigate the effects of the mammalian neuropeptide Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF) on…”
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