Search Results - "Le Marchand Brustel, Y."

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level by Sahra, I Ben, Laurent, K, Loubat, A, Giorgetti-Peraldi, S, Colosetti, P, Auberger, P, Tanti, J F, Le Marchand-Brustel, Y, Bost, F

“…Metformin is a widely used antidiabetic agent, which regulates glucose homeostasis through inhibition of liver glucose production and an increase in muscle…”
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A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin‐18 for the diagnosis of non‐alcoholic steatohepatitis in morbidly obese patients by Anty, R., Iannelli, A., Patouraux, S., Bonnafous, S., Lavallard, V. J., Senni‐Buratti, M., Ben Amor, I., Staccini‐Myx, A., Saint‐Paul, M.‐C., Berthier, F., Huet, P.‐M., Le Marchand‐Brustel, Y., Gugenheim, J., Gual, P., Tran, A.

“…Aliment Pharmacol Ther 2010; 32: 1315–1322 Summary Background  Non‐invasive approaches are useful to differentiate simple steatosis from non‐alcoholic…”
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Rab proteins in endocytosis and Glut4 trafficking by Kaddai, V., Le Marchand-Brustel, Y., Cormont, M.

“…The intracellular trafficking of numerous proteins requires a tight control to fulfil their physiological functions. It is the case of the adipocyte and muscle…”
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The nitric oxide-donating derivative of acetylsalicylic acid, NCX 4016, stimulates glucose transport and glucose transporters translocation in 3T3-L1 adipocytes by Kaddai, V, Gonzalez, T, Bolla, M, Le Marchand-Brustel, Y, Cormont, M

“…NCX 4016 is a nitric oxide (NO)-donating derivative of acetylsalicylic acid. NO and salicylate, in vivo metabolites of NCX 4016, were shown to be potential…”
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Role of MAPKs in development and differentiation: lessons from knockout mice by Aouadi, M., Binetruy, B., Caron, L., Le Marchand-Brustel, Y., Bost, F.

“…The ERK, p38MAPK, JNK mitogen-activated protein kinases (MAPKs) are intracellular signaling pathways that play a pivotal role in many essential cellular…”
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Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity by Jager, J, Corcelle, V, Grémeaux, T, Laurent, K, Waget, A, Pagès, G, Binétruy, B, Le Marchand-Brustel, Y, Burcelin, R, Bost, F, Tanti, J. F

“…Aims/hypothesis Extracellular signal-regulated kinase (ERK) activity is increased in adipose tissue in obesity and type 2 diabetes mellitus and strong…”
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Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling by Tanti, J F, Grémeaux, T, van Obberghen, E, Le Marchand-Brustel, Y

“…Treatment of cells with okadaic acid, a protein phosphatase inhibitor, leads to an insulin-resistant state without modification in the tyrosine kinase activity…”
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p38MAP Kinase activity is required for human primary adipocyte differentiation by Aouadi, M., Jager, J., Laurent, K., Gonzalez, T., Cormont, M., Binétruy, B., Le Marchand-Brustel, Y., Tanti, J.-F., Bost, F.

“…Little is known about the role of p38MAPK in human adipocyte differentiation. Here we showed that p38MAPK activity increases during human preadipocytes…”
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MAP kinases and mTOR mediate insulin-induced phosphorylation of Insulin Receptor Substrate-1 on serine residues 307, 612 and 632 by GUAL, P, GREMEAUX, T, GONZALEZ, T, LE MARCHAND-BRUSTEL, Y, TANTI, J.-F

“…Insulin-induced IRS-1 serine phosphorylation could be physiologically important to regulate insulin action. In a hyperinsulinaemic state such as obesity or…”
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Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress by Bloch-Damti, A, Potashnik, R, Gual, P, Le Marchand-Brustel, Y, Tanti, J. F, Rudich, A, Bashan, N

“…Aims/hypothesis Induction of stress kinases leading to serine hyperphosphorylation of IRS1 may link oxidative stress to insulin resistance. The aim of this…”
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Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice by PI-YIN CHANG, BENECKE, H, LE MARCHAND-BRUSTEL, Y, LEWITTS, J, MOLLER, D. E

“…To examine the in vivo effects of a kinase-deficient mutant human insulin receptor, we used the muscle creatine kinase promoter to express a putative…”
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The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis by BOST, Frédéric, AOUADI, Myriam, LE MARCHAND-BRUSTEL, Yannick, BINETRUY, Bernard, CARON, Leslie, EVEN, Patrick, BELMONTE, Nathalie, PROT, Matthieu, DANI, Christian, HOFMAN, Paul, PAGES, Gilles, POUYSSEGUR, Jacques

“…The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis Frédéric Bost 1 , Myriam Aouadi 1 ,…”
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Insulin and okadaic acid induce Rab4 redistribution in adipocytes by Cormont, M, Tanti, J F, Zahraoui, A, Van Obberghen, E, Tavitian, A, Le Marchand-Brustel, Y

“…Insulin stimulation of glucose transport involves the translocation of vesicles containing the glucose transporter Glut 4 to the plasma membrane. Rab proteins,…”
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The role of small G-proteins in the regulation of glucose transport (review) by Cormont, M, Le Marchand-Brustel, Y

“…Insulin increases the rate of glucose transport into fat and muscle cells by stimulating the translocation of intracellular Glut 4-containing vesicles to the…”
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Involvement of TNF-α in abnormal adipocyte and muscle sortilin expression in obese mice and humans by Kaddai, V, Jager, J, Gonzalez, T, Najem-Lendom, R, Bonnafous, S, Tran, A, Le Marchand-Brustel, Y, Gual, P, Tanti, J.-F, Cormont, M

“…Aims/hypothesis Insulin resistance is caused by numerous factors including inflammation. It is characterised by defective insulin stimulation of adipocyte and…”
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Early alteration of insulin stimulation of PI 3-kinase in muscle and adipocyte from gold thioglucose obese mice by Heydrick, S J, Gautier, N, Olichon-Berthe, C, Van Obberghen, E, Le Marchand-Brustel, Y

“…The activation of phosphatidylinositol 3-kinase (PIK) was studied in vivo and in vitro in soleus muscle and adipocytes from young (8 wk) and old (30 wk) gold…”
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Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling by Le Marchand-Brustel, Y, Gual, P, Grémeaux, T, Gonzalez, T, Barrès, R, Tanti, J-F

“…Insulin resistance, when combined with impaired insulin secretion, contributes to the development of type 2 diabetes. Insulin resistance is characterized by a…”
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378 HUMAN SERUM METABOLIC PROFILING REVEALS NOVEL BIOMARKERS ASSOCIATED WITH NAFLD PROGRESSION by Vazquez-Chantada, M, Barr, J, Alonso, C, Galan, A, Tran, A, Tordjman, J, Le Marchand-Brustel, Y, Gual, P, Martinez-Chantar, M, Lu, S.C, Castro, A, Mato, J.M

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133 THE INVALIDATION OF OSTEOPONTIN AGGRAVES THE HEPATIC INJURIES INDUCED BY ISCHEMIA-REPERFUSION IN MICE by Rubio, A, Lauron, J, Rousseau, D, Bailly-Maitre, B, Lavallard, V, Saint-Paul, M.C, Le Marchand-Brustel, Y, Tran, A, Crenesse, D, Gual, P

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93 C-REACTIVE PROTEIN INHIBITS INSULIN SIGNALLING PATHWAY IN BOTH HUMAN HEPATOCYTES AND ADIPOCYTES by Bertola, A, Anty, R, Bonnafous, S, Le Marchand-Brustel, Y, Tran, A, Gual, P

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