Search Results - "Le Maitre, Christine"

Injectable hydrogel induces regeneration of naturally degenerate human intervertebral discs in a loaded organ culture model by Cherif, Hosni, Li, Li, Snuggs, Joseph, Li, Xuan, Sammon, Christopher, Li, Jianyu, Beckman, Lorne, Haglund, Lisbet, Le Maitre, Christine. L．

“…Low back pain resulting from disc degeneration is a leading cause of disability worldwide. However, to date few therapies target the cause and fail to repair…”
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The effect of apigenin and chemotherapy combination treatments on apoptosis-related genes and proteins in acute leukaemia cell lines by Mahbub, Amani A., Le Maitre, Christine L., Cross, Neil A., Jordan-Mahy, Nicola

“…Apigenin is a dietary polyphenol found abundantly in fruit and vegetables, which sensitizes leukaemia cells to topoisomerase inhibitor agents (e.g.,…”
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Long-term in vitro 3D hydrogel co-culture model of inflammatory bowel disease by Dosh, Rasha H., Jordan-Mahy, Nicola, Sammon, Christopher, Le Maitre, Christine L.

“…The in vitro study of the pathogenesis of inflammatory bowel disease (IBD) requires a cell model which closely reflects the characteristics of the in vivo…”
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Impact of leptin deficiency on male tibia and vertebral body 3D bone architecture independent of changes in body weight by Williamson, Alexander, Silva, Alexandre, Carmo, Jussara M., Le Maitre, Christine L., Hall, John E., Aberdein, Nicola

“…Leptin an adipokine with potent effects on energy balance and body weight plays an important role in defining bone architecture in growing mammals. However,…”
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The strain-generated electrical potential in cartilaginous tissues: a role for piezoelectricity by Poillot, Philip, Le Maitre, Christine L., Huyghe, Jacques M.

“…The strain-generated potential (SGP) is a well-established mechanism in cartilaginous tissues whereby mechanical forces generate electrical potentials. In…”
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Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration by Bach, Frances C, Poramba-Liyanage, Deepani W, Riemers, Frank M, Guicheux, Jerome, Camus, Anne, Iatridis, James C, Chan, Danny, Ito, Keita, Le Maitre, Christine L, Tryfonidou, Marianna A

“…Chronic low back pain is the number one cause of years lived with disability. In about 40% of patients, chronic lower back pain is related to intervertebral…”
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Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study by Le Maitre, Christine L, Hoyland, Judith A, Freemont, Anthony J

“…Data implicate IL-1 in the altered matrix biology that characterizes human intervertebral disc (IVD) degeneration. In the current study we investigated the…”
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Molecular Action of Polyphenols in Leukaemia and Their Therapeutic Potential by Alaswad, Hamza A, Mahbub, Amani A, Le Maitre, Christine L, Jordan-Mahy, Nicola

“…Leukaemia is a malignant disease of the blood. Current treatments for leukaemia are associated with serious side-effects. Plant-derived polyphenols have been…”
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The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc by Phillips, Kate L E, Chiverton, Neil, Michael, Anthony L R, Cole, Ashley A, Breakwell, Lee M, Haddock, Gail, Bunning, Rowena A D, Cross, Alison K, Le Maitre, Christine L

“…The aims of these studies were to identify the cytokine and chemokine expression profile of nucleus pulposus (NP) cells and to determine the relationships…”
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Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research by Baumgartner, Laura, Wuertz-Kozak, Karin, Le Maitre, Christine L, Wignall, Francis, Richardson, Stephen M, Hoyland, Judith, Ruiz Wills, Carlos, González Ballester, Miguel A, Neidlin, Michael, Alexopoulos, Leonidas G, Noailly, Jérôme

“…Intervertebral disc (IVD) degeneration is a major risk factor of low back pain. It is defined by a progressive loss of the IVD structure and functionality,…”
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Effects of bioactive compounds from carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid leukaemia cells by Zaini, Rana G, Brandt, Kirsten, Clench, Malcolm R, Le Maitre, Christine L

“…New therapies for leukaemia are urgently needed. Carrots have been suggested as a potential treatment for leukaemia in traditional medicine and have previously…”
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Cellular Responses to Extracellular Vesicles as Potential Markers of Colorectal Cancer Progression by Guarnerio, Sonia, Tempest, Robert, Maani, Rawan, Hunt, Stuart, Cole, Laura M, Le Maitre, Christine L, Chapple, Keith, Peake, Nicholas

“…The development of novel screening tests aims to support early asymptomatic diagnosis and subtyping patients according to similar traits in the heterogeneous…”
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Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis by Steinberg, Julia, Ritchie, Graham R. S., Roumeliotis, Theodoros I., Jayasuriya, Raveen L., Clark, Matthew J., Brooks, Roger A., Binch, Abbie L. A., Shah, Karan M., Coyle, Rachael, Pardo, Mercedes, Le Maitre, Christine L., Ramos, Yolande F. M., Nelissen, Rob G. H. H., Meulenbelt, Ingrid, McCaskie, Andrew W., Choudhary, Jyoti S., Wilkinson, J. Mark, Zeggini, Eleftheria

“…Osteoarthritis (OA) is a common disease characterized by cartilage degeneration and joint remodeling. The underlying molecular changes underpinning disease…”
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Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model by Taylor-Whiteley, Teresa R, Le Maitre, Christine L, Duce, James A, Dalton, Caroline F, Smith, David P

“…Extensive loss of dopaminergic neurons and aggregation of the protein α-synuclein into ubiquitin-positive Lewy bodies represents a major neuropathological…”
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An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue by Le Maitre, Christine L, Baird, Pauline, Freemont, Anthony J, Hoyland, Judith A

“…The decreased disc height characteristic of intervertebral disc (IVD) degeneration has often been linked to low back pain, and thus regeneration strategies…”
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Immunohistochemical analysis of protein expression in formalin fixed paraffin embedded human intervertebral disc tissues by Binch, Abbie, Snuggs, Joseph, Le Maitre, Christine L.

“…Immunohistochemistry (IHC) is a useful technique for the localization and semiquantification of protein expression within tissues. Adult human intervertebral…”
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Immuno-Modulatory Effects of Intervertebral Disc Cells by Bermudez-Lekerika, Paola, Crump, Katherine B., Tseranidou, Sofia, Nüesch, Andrea, Kanelis, Exarchos, Alminnawi, Ahmad, Baumgartner, Laura, Muñoz-Moya, Estefano, Compte, Roger, Gualdi, Francesco, Alexopoulos, Leonidas G., Geris, Liesbet, Wuertz-Kozak, Karin, Le Maitre, Christine L., Noailly, Jérôme, Gantenbein, Benjamin

“…Low back pain is a highly prevalent, chronic, and costly medical condition predominantly triggered by intervertebral disc degeneration (IDD). IDD is often…”
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Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative by Le Maitre, Christine L., Dahia, Chitra L., Giers, Morgan, Illien‐Junger, Svenja, Cicione, Claudia, Samartzis, Dino, Vadala, Gianluca, Fields, Aaron, Lotz, Jeffrey

“…Background Histopathological analysis of intervertebral disc (IVD) tissues is a critical domain of back pain research. Identification, description, and…”
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Use of l-pNIPAM hydrogel as a 3D-scaffold for intestinal crypts and stem cell tissue engineering by Dosh, Rasha H, Jordan-Mahy, Nicola, Sammon, Christopher, Le Maitre, Christine L

“…Intestinal stem cells hold great potential in tissue regeneration of the intestine, however, there are key limitations in their culture in vitro. We previously…”
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Correction: Bermudez-Lekerika et al. Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems. Gels 2024, 10 , 330 by Bermudez-Lekerika, Paola, Crump, Katherine B, Wuertz-Kozak, Karin, Le Maitre, Christine L, Gantenbein, Benjamin

“…In the original publication [...]…”
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