Search Results - "Le Hellard, S"

Epigenetic association with environmental risk factors for mental disorders by Le Hellard, S.

“…Abstract Body Major mental disorders have typically a complex aetiology where both genetic and environmental risk factors have been implicated. It has also…”
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Genome-wide association studies in psychiatry: Current perspectives by Smajlagic, D., Zayats, T., Bekkehus, M., Le Hellard, S.

“…Abstract Body Genome-wide Association Studies in Psychiatry - Current Perspectives Last decade was exciting time for human genetic studies. Genome-wide…”
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Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the scottish population by THOMSON, P. A, WRAY, N. R, MILLAR, J. K, EVANS, K. L, LE HELLARD, S, CONDIE, A, MUIR, W. J, BLACKWOOD, D. H. R, PORTEOUS, D. J

“…The Translin-associated factor X/Disrupted in Schizophrenia 1 (TRAX/DISC) region was first implicated as a susceptibility locus for schizophrenia by analysis…”
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Association between the insulin-induced gene 2 ( ) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? by Le Hellard, S, Theisen, F M, Haberhausen, M, Raeder, M B, Fernø, J, Gebhardt, S, Hinney, A, Remschmidt, H, Krieg, J C, Mehler-Wex, C, Nöthen, M M, Hebebrand, J, Steen, V M

“…Atypical antipsychotics are nowadays the most widely used drugs to treat schizophrenia and other psychosis. Unfortunately, some of them can cause major…”
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Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p by Christoforou, A, McGhee, K A, Morris, S W, Thomson, P A, Anderson, S, McLean, A, Torrance, H S, Le Hellard, S, Pickard, B S, StClair, D, Muir, W J, Blackwood, D H, Porteous, D J, Evans, K L

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Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples by Le Hellard, S, Mühleisen, T W, Djurovic, S, Fernø, J, Ouriaghi, Z, Mattheisen, M, Vasilescu, C, Raeder, M B, Hansen, T, Strohmaier, J, Georgi, A, Brockschmidt, F F, Melle, I, Nenadic, I, Sauer, H, Rietschel, M, Nöthen, M M, Werge, T, Andreassen, O A, Cichon, S, Steen, V M

“…Several studies have reported structural brain abnormalities, decreased myelination and oligodendrocyte dysfunction in schizophrenia. In the central nervous…”
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How Mutations in the nAChRs Can Cause ADNFLE Epilepsy by Bertrand, D., Picard, F., Le Hellard, S., Weiland, S., Favre, I., Phillips, H., Bertrand, S., Berkovic, S. F., Malafosse, A., Mulley, J.

“…Purpose: The linkage between autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) and neuronal nicotinic acetylcholine receptor has been strongly…”
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GWAS‐based pathway analysis differentiates between fluid and crystallized intelligence by Christoforou, A., Espeseth, T., Davies, G., Fernandes, C. P. D., Giddaluru, S., Mattheisen, M., Tenesa, A., Harris, S. E., Liewald, D. C., Payton, A., Ollier, W., Horan, M., Pendleton, N., Haggarty, P., Djurovic, S., Herms, S., Hoffman, P., Cichon, S., Starr, J. M., Lundervold, A., Reinvang, I., Steen, V. M., Deary, I. J., Le Hellard, S.

“…Cognitive abilities vary among people. About 40–50% of this variability is due to general intelligence (g), which reflects the positive correlation among…”
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Potential association of muscarinic receptor 3 gene variants with primary Sjogren's syndrome by Appel, Silke, Le Hellard, Stephanie, Bruland, Ove, Brun, Johan G, Omdal, Roald, Kristjansdottir, Gudlaug, Theander, Elke, Nordmark, Gunnel, Kvarnström, Marika, Eriksson, Per, Rönnblom, Lars, Wahren-Herlenius, Marie, Jonsson, Roland

“…Primary Sjögren's syndrome (pSS) is characterised by a chronic inflammation of exocrine glands. Salivary gland infiltrates, however, do not correlate well with…”
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No association of primary Sjögren’s syndrome with Fcγ receptor gene variants by Haldorsen, K, Appel, S, Le Hellard, S, Bruland, O, Brun, J G, Omdal, R, Kristjansdottir, G, Theander, E, Fernandes, C P D, Kvarnström, M, Eriksson, P, Rönnblom, L, Herlenius, M W, Nordmark, G, Jonsson, R, Bolstad, A I

“…The genetic background of primary Sjögren’s syndrome (pSS) is partly shared with systemic lupus erythematosus (SLE). Immunoglobulin G Fc receptors are…”
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Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia by CHRISTOFOROU, A, LE HELLARD, S, EVANS, K. L, THOMSON, P. A, MORRIS, S. W, TENESA, A, PICKARD, B. S, WRAY, N. R, MUIR, W. J, BLACKWOOD, D. H, PORTEOUS, D. J

“…Several independent linkage studies have identified chromosome 4p15-p16 as a putative region of susceptibility for bipolar disorder (BP), schizophrenia (SCZ)…”
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Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia by Underwood, S L, Christoforou, A, Thomson, P A, Wray, N R, Tenesa, A, Whittaker, J, Adams, R A, Le Hellard, S, Morris, S W, Blackwood, D H R, Muir, W J, Porteous, D J, Evans, K L

“…The orphan G protein-coupled receptor 78 (GPR78) gene lies within a region of chromosome 4p where we have previously shown linkage to bipolar affective…”
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A possible association between schizophrenia and GRIK3 polymorphisms in a multicenter sample of Scandinavian origin (SCOPE) by Djurovic, S, Kähler, A.K, Kulle, B, Jönsson, E.G, Agartz, I, Le Hellard, S, Hall, H, Jakobsen, K.D, Hansen, T, Melle, I, Werge, T, Steen, V.M, Andreassen, O.A

“…Abstract There is considerable evidence of altered glutamatergic signalling in schizophrenia and a polymorphic variant of the GRIK3 glutamate receptor gene on…”
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Nationwide Genomic Study in Denmark Reveals Remarkable Population Homogeneity by Athanasiadis, Georgios, Cheng, Jade Y, Vilhjálmsson, Bjarni J, Jørgensen, Frank G, Als, Thomas D, Le Hellard, Stephanie, Espeseth, Thomas, Sullivan, Patrick F, Hultman, Christina M, Kjærgaard, Peter C, Schierup, Mikkel H, Mailund, Thomas

“…Denmark has played a substantial role in the history of Northern Europe. Through a nationwide scientific outreach initiative, we collected genetic and…”
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Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population by Thomson, P A, Wray, N R, Millar, J K, Evans, K L, Le Hellard, S, Condie, A, Muir, W J, Blackwood, D H R, Porteous, D J

“…The Translin-associated factor X/Disrupted in Schizophrenia 1 (TRAX/DISC) region was first implicated as a susceptibility locus for schizophrenia by analysis…”
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Association between genetic variants in the tumour necrosis factor/lymphotoxin α/lymphotoxin β locus and primary Sjogren's syndrome in Scandinavian samples by Bolstad, Anne Isine, Le Hellard, Stephanie, Kristjansdottir, Gudlaug, Vasaitis, Lilian, Kvarnström, Marika, Sjöwall, Christopher, Johnsen, Svein Joar Auglænd, Eriksson, Per, Omdal, Roald, Brun, Johan G, Wahren-Herlenius, Marie, Theander, Elke, Syvänen, Ann-Christine, Rönnblom, Lars, Nordmark, Gunnel, Jonsson, Roland

“…Lymphotoxin β (LTB) has been found to be upregulated in salivary glands of patients with primary Sjögren's syndrome (pSS). An animal model of pSS also showed…”
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Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder by Hughes, Timothy, Sønderby, Ida E., Polushina, Tatiana, Hansson, Lars, Holmgren, Asbjørn, Athanasiu, Lavinia, Melbø-Jørgensen, Christian, Hassani, Sahar, Hoeffding, Louise K., Herms, Stefan, Bergen, Sarah E., Karlsson, Robert, Song, Jie, Rietschel, Marcella, Nöthen, Markus M., Forstner, Andreas J., Hoffmann, Per, Hultman, Christina M., Landén, Mikael, Cichon, Sven, Werge, Thomas, Andreassen, Ole A., Le Hellard, Stephanie, Djurovic, Srdjan

“…Ankyrin-3 (ANK3) is one of the few genes that have been consistently identified as associated with bipolar disorder by multiple genome-wide association…”
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Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes by Stokowy, Tomasz, Polushina, Tatiana, Sønderby, Ida E., Karlsson, Robert, Giddaluru, Sudheer, Le Hellard, Stephanie, Bergen, Sarah E., Sullivan, Patrick F., Andreassen, Ole A., Djurovic, Srdjan, Hultman, Christina M., Steen, Vidar M.

“…Schizophrenia is a serious psychotic disorder with high heritability. Several common genetic variants, rare copy number variants and ultra-rare gene-disrupting…”
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Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins by Hill, W D, Davies, G, van de Lagemaat, L N, Christoforou, A, Marioni, R E, Fernandes, C P D, Liewald, D C, Croning, M D R, Payton, A, Craig, L C A, Whalley, L J, Horan, M, Ollier, W, Hansell, N K, Wright, M J, Martin, N G, Montgomery, G W, Steen, V M, Le Hellard, S, Espeseth, T, Lundervold, A J, Reinvang, I, Starr, J M, Pendleton, N, Grant, S G N, Bates, T C, Deary, I J

“…Differences in general cognitive ability (intelligence) account for approximately half of the variation in any large battery of cognitive tests and are…”
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A possible genetic association with chronic fatigue in primary Sjögren’s syndrome: a candidate gene study by Norheim, Katrine Brække, Le Hellard, Stephanie, Nordmark, Gunnel, Harboe, Erna, Gøransson, Lasse, Brun, Johan G., Wahren-Herlenius, Marie, Jonsson, Roland, Omdal, Roald

“…Fatigue is prevalent and disabling in primary Sjögren’s syndrome (pSS). Results from studies in chronic fatigue syndrome (CFS) indicate that genetic variation…”
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