Search Results - "Le Hégarat, L."

The PERICLES research program: An integrated approach to characterize the combined effects of mixtures of pesticide residues to which the French population is exposed by Crépet, A, Héraud, F, Béchaux, C, Gouze, M.E, Pierlot, S, Fastier, A, Leblanc, J.Ch, Le Hégarat, L, Takakura, N, Fessard, V, Tressou, J, Maximilien, R, de Sousa, G, Nawaz, A, Zucchini-Pascal, N, Rahmani, R, Audebert, M, Graillot, V, Cravedi, J.P

“…Abstract Due to the broad spectrum of pesticide usages, consumers are exposed to mixtures of residues, which may have combined effects on human health. The…”
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Modulation of CYP3A4 activity alters the cytotoxicity of lipophilic phycotoxins in human hepatic HepaRG cells by Ferron, P.J., Hogeveen, K., De Sousa, G., Rahmani, R., Dubreil, E., Fessard, V., Le Hegarat, L.

“…The aim of this study was to investigate (i) the cytotoxic effects of lipophilic phycotoxins, including okadaic acid (OA) and dinophysistoxin-1 and -2 (DTX-1…”
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P03-08 Metabolism of Enniatin B in primary mouse, rat and human hepatocytes by Dubreil, E., Ivanova, L., Gendre, C., Mahdjoub, M., Fessard, V., Le Hégarat, L., Faeste, C., Henri, J.

“…Enniatins produced by Fusarium species belong to emerging mycotoxins commonly found in cereals and raising concern for food and feed. They are potentially…”
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New human intestinal embryonic cell model (HIEC) for toxicity and genotoxicity studies of xenobiotics by Kopp, B., Ferron, P.-J., Fessard, V., Beaulieu, J.-F., Le Hegarat, L.

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P1-03: A multi-omics strategy to depict and compare the hepatotoxic mechanisms of chlordecone and its metabolite chlordecol by Léger, T., Alilat, S., Dec, L., Hogeveen, K., Ferron, P.-J., Huet, S., Devriendt-Renault, Y., Parinet, J., Fessard, V., Le Hégarat, L.

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In vitro combined cytotoxic effects of pesticide mixtures simultaneously found in the French diet by Le Hegarat, L., Takakura, N., Fessard, V.

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Aneugenic potential of okadaic acid revealed by the micronucleus assay combined with the FISH technique in CHO-K1 cells by Le Hegarat, Ludovic, Puech, Lilian, Fessard, Valérie, Poul, Jean Michel, Dragacci, Sylviane

“…Okadaic acid (OA) is a major toxin involved in diarrhetic shellfish poisoning in humans and has been shown to be both a potent tumor promoter in rodent skin…”
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Genotoxicity of the marine toxin okadaic acid, in human Caco-2 cells and in mice gut cells by Le Hégarat, Ludovic, Jacquin, Anne-Gaëlle, Bazin, Emmanuelle, Fessard, Valérie

“…Micronucleus induction by the diarrhetic shellfish toxin okadaic acid (OA) was investigated in two intestinal models, cultured human Caco‐2 cells and colon…”
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P20-04: Complements on Enniatin B metabolism for interspecies QIVIVE and risk assessment in human by Henri, J., Dubreil, E., Fessard, V., Martin, S., Bree, F., Le Hegarat, L.

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Lack of DNA damage induction by okadaic acid, a marine toxin, in the CHO-Hprt and the in vitro UDS assays by Le Hégarat, Ludovic, Nesslany, Fabrice, Mourot, Annick, Marzin, Daniel, Fessard, Valérie

“…Okadaic acid (OA) is a marine toxin produced by dinoflagellates and responsible for human intoxications. OA is a specific inhibitor of serine/threonine protein…”
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Marine toxin okadaic acid induces aneuploidy in CHO-K1 cells in presence of rat liver postmitochondrial fraction, revealed by cytokinesis-block micronucleus assay coupled to FISH by Le Hegarat, L, Fessard, V, Poul, J.M, Dragacci, S, Sanders, P

“…Okadaic acid (OA), a major polyether toxin involved in diarrhetic shellfish poisoning (DSP), is a potent tumor promoter in rodent skin and glandular stomach…”
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Automatic clod detection and boundary estimation from Digital Elevation Model images using different approaches by Chimi-Chiadjeu, Olivier, Le Hégarat-Mascle, Sylvie, Vannier, Edwige, Taconet, Odile, Dusséaux, Richard

“…Soil micro-topography characterization is an important issue for both soil science and remote sensing data interpretation. The objective of present study is to…”
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Mixtures of Lipophilic Phycotoxins: Exposure Data and Toxicological Assessment by Alarcan, Jimmy, Biré, Ronel, Le Hégarat, Ludovic, Fessard, Valérie

“…Lipophilic phycotoxins are secondary metabolites produced by phytoplanktonic species. They accumulate in filter-feeding shellfish and can cause human…”
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Genotoxicity and mutagenicity assessment of food contaminant mixtures present in the French diet by Kopp, B., Vignard, J., Mirey, G., Fessard, V., Zalko, D., Le Hgarat, L., Audebert, M.

“…Through diet, people are exposed simultaneously to a variety of contaminants (e.g. heavy metals, mycotoxins, pesticides) that could have combined adverse…”
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Investigation of the genotoxicity of the mycotoxins nivalenol and deoxynivalenol through a multiendpoint assay in mouse combining micronucleus and comet assays in multiple organs and Pig-A assay by Le Hegarat, L., Takakura, N., Simar, S., Nesslany, F., Fessard, V.

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Effects of food chemical contaminants in human HepaRG and Caco-2 cells using an automated microscopy and high content analysis based approach by Ferron, P.-J., Huet, S., Hogeveen, K., Fessard, V., Anses, L. Le Hegarat

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Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays by Le Hegarat, Ludovic, Dumont, Julie, Josse, Rozenn, Huet, Sylvie, Lanceleur, Rachelle, Mourot, Annick, Poul, Jean-Michel, Guguen-Guillouzo, Christiane, Guillouzo, André, Fessard, Valérie

“…Many chemical carcinogens require metabolic activation to form genotoxic compounds in human. Standard in vitro genotoxicity assays performed with activation…”
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A co-culture system of human intestinal Caco-2 cells and lymphoblastoid TK6 cells for investigating the genotoxicity of oral compounds by LE HEGARAT, Ludovic, HUET, Sylvie, FESSARD, Valérie

“…Here, we assessed a co-culture system of intestinal Caco-2 cells and lymphoblastoid TK6 cells for modelling the role of intestinal first-pass effects, i.e…”
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strategy to study genotoxicity: application to aquatic toxins, limits and solutions by Fessard, Valérie, Le Hégarat, Ludovic

“…Humans can be exposed to aquatic toxins mainly through contamination of food and water (drinking and recreational). Among these toxins, contamination by both…”
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Determination of vegetation cover fraction by inversion of a four-parameter model based on isoline parametrization by KALLEL, A, LE HÉGARAT-MASCLE, S, OTTLÉ, C, HUBERT-MOY, L

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