Search Results - "Le Guillou, Dounia"

Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity by Allard, Julien, Bucher, Simon, Massart, Julie, Ferron, Pierre-Jean, Le Guillou, Dounia, Loyant, Roxane, Daniel, Yoann, Launay, Youenn, Buron, Nelly, Begriche, Karima, Borgne-Sanchez, Annie, Fromenty, Bernard

“…Steatosis is a liver lesion reported with numerous pharmaceuticals. Prior studies showed that severe impairment of mitochondrial fatty acid oxidation (mtFAO)…”
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Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure by Fromenty, Bernard, Lagadic-Gossmann, Dominique, Tête, Arnaud, Begriche, Karima, Pinon, Grégory, Allard, Julien, Le Guillou, Dounia, Bucher, Simon, Sergent, Odile

“…Exposure to xenobiotics could favor the transition of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis in obese patients. Recently, we showed in…”
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Relationships between radial glial progenitors and 5-HT neurons in the paraventricular organ of adult zebrafish - potential effects of serotonin on adult neurogenesis by Pérez, María Rita, Pellegrini, Elisabeth, Cano-Nicolau, Joel, Gueguen, Marie-Madeleine, Menouer-Le Guillou, Dounia, Merot, Yohann, Vaillant, Colette, Somoza, Gustavo M., Kah, Olivier

“…In non‐mammalian vertebrates, serotonin (5‐HT)‐producing neurons exist in the paraventricular organ (PVO), a diencephalic structure containing cerebrospinal…”
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Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages by Groeger, Marko, Matsuo, Koji, Heidary Arash, Emad, Pereira, Ashley, Le Guillou, Dounia, Pino, Cindy, Telles-Silva, Kayque A., Maher, Jacquelyn J., Hsiao, Edward C., Willenbring, Holger

“…Hepatic insulin resistance is recognized as a driver of type 2 diabetes and fatty liver disease but specific therapies are lacking. Here we explore the…”
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The Role of STING in Liver Injury Is Both Stimulus- and Time-Dependent by Siao, Kevin, Le Guillou, Dounia, Maher, Jacquelyn J, Duwaerts, Caroline C

“…STING, Tmem173, is involved in liver injury caused by both infectious and sterile inflammatory models. Its role in toxic liver injury and non-alcoholic fatty…”
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Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo by Bucher, Simon, Tête, Arnaud, Podechard, Normand, Liamin, Marie, Le Guillou, Dounia, Chevanne, Martine, Coulouarn, Cédric, Imran, Muhammad, Gallais, Isabelle, Fernier, Morgane, Hamdaoui, Quentin, Robin, Marie-Anne, Sergent, Odile, Fromenty, Bernard, Lagadic-Gossmann, Dominique

“…Hepatic steatosis (i.e. lipid accumulation) and steatohepatitis have been related to diverse etiologic factors, including alcohol, obesity, environmental…”
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Endotoxin regulates matrix genes increasing reactive oxygen species generation by intercellular communication between palmitate‐treated hepatocyte and stellate cell by Dornas, Waleska, Glaise, Denise, Bodin, Aude, Sharanek, Ahmad, Burban, Audrey, Le Guillou, Dounia, Robert, Sacha, Dutertre, Stephanie, Aninat, Caroline, Corlu, Anne, Lagente, Vincent

“…Previous studies have shown that gut‐derived bacterial endotoxins contribute in the progression of simple steatosis to steatohepatitis, although the…”
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Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure by Bucher, Simon, Jalili, Pégah, Le Guillou, Dounia, Begriche, Karima, Rondel, Karine, Martinais, Sophie, Zalko, Daniel, Corlu, Anne, Robin, Marie‐Anne, Fromenty, Bernard

“…ABSTRACT Human exposure to bisphenol A (BPA) could favor obesity and related metabolic disorders such as hepatic steatosis. Investigations in rodents have…”
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Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice by Anthérieu, Sébastien, Le Guillou, Dounia, Coulouarn, Cédric, Begriche, Karima, Trak-Smayra, Viviane, Martinais, Sophie, Porceddu, Mathieu, Robin, Marie-Anne, Fromenty, Bernard

“…Drinking water can be contaminated with pharmaceuticals. However, it is uncertain whether this contamination can be harmful for the liver, especially during…”
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Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis by Sharma, Sachin, Le Guillou, Dounia, Chen, Jennifer Y.

“…The burden of chronic liver disease is rising substantially worldwide. Fibrosis, characterized by excessive deposition of extracellular matrix proteins, is the…”
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Drug-induced liver injury in obesity and nonalcoholic fatty liver disease by Allard, Julien, Le Guillou, Dounia, Begriche, Karima, Fromenty, Bernard

“…Obesity is commonly associated with nonalcoholic fatty liver (NAFL), a benign condition characterized by hepatic lipid accumulation. However, NAFL can progress…”
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iPSC-derived hepatocytes from patients with nonalcoholic fatty liver disease display a disease-specific gene expression profile by Duwaerts, Caroline C., Le Guillou, Dounia, Her, Chris L., Phillips, Nathaniel J., Willenbring, Holger, Mattis, Aras N., Maher, Jacquelyn J.

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Induced Pluripotent Stem Cell–derived Hepatocytes From Patients With Nonalcoholic Fatty Liver Disease Display a Disease-specific Gene Expression Profile by Duwaerts, Caroline C., Le Guillou, Dounia, Her, Chris L., Phillips, Nathaniel J., Willenbring, Holger, Mattis, Aras N., Maher, Jacquelyn J.

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A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen by Michaut, Anaïs, Le Guillou, Dounia, Moreau, Caroline, Bucher, Simon, McGill, Mitchell R., Martinais, Sophie, Gicquel, Thomas, Morel, Isabelle, Robin, Marie-Anne, Jaeschke, Hartmut, Fromenty, Bernard

“…Obesity and nonalcoholic fatty liver disease (NAFLD) can increase susceptibility to hepatotoxicity induced by some xenobiotics including drugs, but the…”
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Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure by Bucher, Simon, Le Guillou, Dounia, Allard, Julien, Pinon, Grégory, Begriche, Karima, Tête, Arnaud, Sergent, Odile, Lagadic-Gossmann, Dominique, Fromenty, Bernard

“…Exposure to xenobiotics could favor the transition of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis in obese patients. Recently, we showed in…”
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Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo by Bucher, Simon, Tête, Arnaud, Podechard, Normand, Liamin, Marie, Le Guillou, Dounia, Chevanne, Martine, Coulouarn, Cédric, Imran, Muhammad, Gallais, Isabelle, Fernier, Morgane, Hamdaoui, Quentin, Robin, Marie-Anne, Sergent, Odile, Fromenty, Bernard, Lagadic-Gossmann, Dominique

“…Abstract Hepatic steatosis (i.e. lipid accumulation) and steatohepatitis have been related to diverse etiologic factors, including alcohol, obesity,…”
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Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure: BISPHENOL A-INDUCED STEATOSIS IN HepaRG CELLS by Bucher, Simon, Jalili, Pégah, Le Guillou, Dounia, Begriche, Karima, Rondel, Karine, Martinais, Sophie, Zalko, Daniel, Corlu, Anne, Robin, Marie-Anne, Fromenty, Bernard

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Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure by Bucher, Simon, Le Guillou, Dounia, Allard, Julien, Pinon, Grégory M., Begriche, Karima, Tête, Arnaud, Sergent, Odile, Lagadic-Gossmann, Dominique, Fromenty, Bernard

“…Exposure to xenobiotics could favor the transition of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis in obese patients. Recently, we showed in…”
Get full text

Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure by Bucher, Simon, Le Guillou, Dounia, Allard, Julien, Pinon, Grégory M., Begriche, Karima, Tête, Arnaud, Sergent, Odile, Lagadic-Gossmann, Dominique, Fromenty, Bernard

“…Exposure to xenobiotics could favor the transition of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis in obese patients. Recently, we showed in…”
Get full text