Search Results - "Le Guern, Marie–Emmanuelle"

Stiripentol in Dravet syndrome: Results of a retrospective U.S. study by Wirrell, Elaine C., Laux, Linda, Franz, David N., Sullivan, Joseph, Saneto, Russell P., Morse, Richard P., Devinsky, Orrin, Chugani, Harry, Hernandez, Angel, Hamiwka, Lorie, Mikati, Mohamad A., Valencia, Ignacio, Le Guern, Marie‐Emmanuelle, Chancharme, Laurent, Menezes, Marcio Sotero

“…Summary Purpose To review the efficacy and tolerability of stiripentol in the treatment of U.S. children with Dravet syndrome. Methods U.S. clinicians who had…”
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Saccharomyces boulardii Does Not Prevent Relapse of Crohn's Disease by Bourreille, Arnaud, Cadiot, Guillaume, Le Dreau, Gérard, Laharie, David, Beaugerie, Laurent, Dupas, Jean–Louis, Marteau, Philippe, Rampal, Patrick, Moyse, Dominique, Saleh, Ashraf, Le Guern, Marie–Emmanuelle, Galmiche, Jean–Paul

“…Background & Aims Saccharomyces boulardii is a probiotic yeast that has been shown to have beneficial effects on the intestinal epithelial barrier and…”
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Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice by Hoffmann, Thomas W, Pham, Hang-Phuong, Bridonneau, Chantal, Aubry, Camille, Lamas, Bruno, Martin-Gallausiaux, Camille, Moroldo, Marco, Rainteau, Dominique, Lapaque, Nicolas, Six, Adrien, Richard, Mathias L, Fargier, Emilie, Le Guern, Marie-Emmanuelle, Langella, Philippe, Sokol, Harry

“…Studying host–microbiota interactions are fundamental to understanding the mechanisms involved in intestinal homeostasis and inflammation. In this work, we…”
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Endotoxemia causes a paradoxical intracellular pH recovery in exercising rat skeletal muscle by Giannesini, Benoît, Izquierdo, Marguerite, Dalmasso, Christiane, Fur, Yann Le, Cozzone, Patrick J., Verleye, Marc, Guern, Marie-Emmanuelle Le, Gillardin, Jean-Marie, Bendahan, David

“…In resting skeletal muscle, endotoxemia causes disturbances in energy metabolism that could potentially disturb intracellular pH (pHi) during muscular…”
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Endotoxemia does not limit energy supply in exercising rat skeletal muscle by Giannesini, Benoit, Izquierdo, Marguerite, Dalmasso, Christiane, Fur, Yann Le, Cozzone, Patrick J., Verleye, Marc, Guern, Marie-Emmanuelle Le, Gillardin, Jean-Marie, Bendahan, David

“…Although depletion in high‐energy phosphorylated compounds and mitochondrial impairment have been reported in septic skeletal muscle at rest, their impact on…”
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An Update on Stiripentol Mechanisms of Action: A Narrative Review by Bacq, Alexandre, Depaulis, Antoine, Castagné, Vincent, Le Guern, Marie-Emmanuelle, Wirrell, Elaine C., Verleye, Marc

“…Stiripentol (Diacomit ® ) (STP) is an orally active antiseizure medication (ASM) indicated as adjunctive therapy, for the treatment of seizures associated with…”
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Reassessment of stiripentol pharmacokinetics in healthy adult volunteers by Peigné, Sophie, Rey, Elisabeth, Le Guern, Marie-Emmanuelle, Dulac, Olivier, Chiron, Catherine, Pons, Gerard, Jullien, Vincent

“…Highlights • We assessed the pharmacokinetics of stiripentol in 12 healthy volunteers. • No concentration rebound was observed during its disposition phase. •…”
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Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle by Giannesini, Benoît, Le Fur, Yann, Cozzone, Patrick J., Verleye, Marc, Le Guern, Marie-Emmanuelle, Bendahan, David

“…Citrulline malate (CM; CAS 54940-97-5, Stimol®) is known to limit the deleterious effect of asthenic state on muscle function, but its effect under healthy…”
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Nefopam Pharmacokinetics in Patients with End-Stage Renal Disease by Mimoz, Olivier, Chauvet, Stéphane, Grégoire, Nicolas, Marchand, Sandrine, Le Guern, Marie-Emmanuelle, Saleh, Ashraf, Couet, William, Debaene, Bertrand, Levy, René H.

“…Treatment of intense postoperative pain in patients with end-stage renal disease (ESRD) is a recurrent problem for anesthesiologists because of the risk of…”
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Nefopam enantiomers: Preclinical pharmacology/toxicology and pharmacokinetic characteristics in healthy subjects after intravenous administration by Mather, Gary G., Labroo, Rita, Le Guern, Marie-Emmanuelle, Lepage, Francis, Gillardin, Jean-Marie, Levy, René H.

“…Nefopam (NEF) is a potent analgesic compound administered as a racemic mixture. Previous in vitro and in vivo studies with nefopam enantiomers have shown that…”
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Beneficial effects of citrulline malate on skeletal muscle function in endotoxemic rat by Giannesini, Benoît, Izquierdo, Marguerite, Le Fur, Yann, Cozzone, Patrick J., Verleye, Marc, Le Guern, Marie-Emmanuelle, Gillardin, Jean-Marie, Bendahan, David

“…Although citrulline malate (CM; CAS 54940-97-5, Stimol ®) is used against fatigue states, its anti-asthenic effect remains poorly documented. The objective of…”
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Effect of route of administration on the pharmacokinetic behavior of enantiomers of nefopam and desmethylnefopam by CHAWLA, Jyoti, LE GUERN, Marie-Emmanuelle, ALQUIER, Christine, KALHORN, Thomas F, LEVY, René H

“…Nefopam hydrochloride is a non-narcotic analgesic used parenterally and orally as a racemic mixture for the relief of postoperative pain. However, no…”
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Stiripentol in D ravet syndrome: Results of a retrospective U . S . study by Wirrell, Elaine C., Laux, Linda, Franz, David N., Sullivan, Joseph, Saneto, Russell P., Morse, Richard P., Devinsky, Orrin, Chugani, Harry, Hernandez, Angel, Hamiwka, Lorie, Mikati, Mohamad A., Valencia, Ignacio, Le Guern, Marie‐Emmanuelle, Chancharme, Laurent, de Menezes, Marcio Sotero

“…Summary Purpose To review the efficacy and tolerability of stiripentol in the treatment of U . S . children with D ravet syndrome. Methods U . S . clinicians…”
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Citrulline/malate promotes aerobic energy production in human exercising muscle by Bendahan, D, Mattei, J P, Ghattas, B, Confort-Gouny, S, Le Guern, M E, Cozzone, P J

“…Background: Previous studies have shown an antiasthenic effect of citrulline/malate (CM) but the mechanism of action at the muscular level remains unknown…”
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Endotoxemia causes A paradoxical intracellular pH recovery in exercosing rat skeletal muscle by GIANNESINI, Benoit, IZQUIERDO, Marguerite, DALMASSO, Christiane, LE FUR, Yann, COZZONE, Patrick J, VERLEYE, Marc, LE GUERN, Marie-Emmanuelle, GILLARDIN, Jean-Marie, BENDAHAN, David

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Comparative Pharmacokinetics and Pharmacodynamics of Intravenous and Oral Nefopam in Healthy Volunteers by Aymard, Guy, Warot, Dominique, Démolis, Pierre, Giudicelli, Jean François, Lechat, Philippe, Le Guern, Marie Emmanuelle, Alquier, Christine, Diquet, Bertrand

“…: To determine the pharmacokinetic, subjective effects of a single 20 mg dose of nefopam administered either intravenously or orally in healthy volunteers,…”
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Prevalence and pathogenicity of Clostridium difficile in hospitalized patients. A French multicenter study by Barbut, F, Corthier, G, Charpak, Y, Cerf, M, Monteil, H, Fosse, T, Trévoux, A, De Barbeyrac, B, Boussougant, Y, Tigaud, S, Tytgat, F, Sédallian, A, Duborgel, S, Collignon, A, Le Guern, M E, Bernasconi, P, Petit, J C

“…Although Clostridium difficile is the main agent responsible for nosocomial diarrhea in adults, its prevalence in stool cultures sent to hospital microbiology…”
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