Search Results - "Le Diguarher, T."

Bax Activation by Engagement with, Then Release from, the BH3 Binding Site of Bcl-xL by Gautier, F., Guillemin, Y., Cartron, P. F., Gallenne, T., Cauquil, N., Le Diguarher, T., Casara, P., Vallette, F. M., Manon, S., Hickman, J. A., Geneste, O., Juin, P.

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Stereospecific Synthesis of 5-Substituted 2-Bisarylthiocyclopentane Carboxylic Acids as Specific Matrix Metalloproteinase Inhibitors by Le Diguarher, Thierry, Chollet, Anne-Marie, Bertrand, Marc, Hennig, Philippe, Raimbaud, Eric, Sabatini, Massimo, Guilbaud, Nicolas, Pierré, Alain, Tucker, Gordon C, Casara, Patrick

“…The synthesis and structure−activity relationship (SAR) studies of a series of cyclopentane carboxylic acid matrix metalloproteinase (MMP) inhibitors are…”
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Solid-phase synthesis of α-substituted 3-bisarylthio N-Hydroxy propionamides as Specific MMP Inhibitors by Chollet, Anne-Marie, Le Diguarher, Thierry, Kucharczyk, Nathalie, Loynel, Armelle, Bertrand, Marc, Tucker, Gordon, Guilbaud, Nicolas, Burbridge, Mike, Pastoureau, Philippe, Fradin, Armel, Sabatini, Massimo, Fauchère, Jean-Luc, Casara, Patrick

“…A novel series of potent and specific MMP-2,3,9,13 inhibitors has been obtained by modulation on solid phase by α and aryl substitutions on 3-arylthio-…”
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Bax Activation by Engagement with, Then Release from, the BH3 Binding Site of Bcl-x L by Gautier, F., Guillemin, Y., Cartron, P. F., Gallenne, T., Cauquil, N., Le Diguarher, T., Casara, P., Vallette, F. M., Manon, S., Hickman, J. A., Geneste, O., Juin, P.

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Synthesis of N, N′-disubstituted 3-aminobenzo[ c] and [ d]azepin-2-ones as potent and specific farnesyl transferase inhibitors by Le Diguarher, Thierry, Ortuno, Jean-Claude, Shanks, David, Guilbaud, Nicolas, Pierré, Alain, Raimbaud, Eric, Fauchère, Jean-Luc, Hickman, John A, Tucker, Gordon C, Casara, Patrick J

“…A structure–activity study was performed by synthesis on N, N′-disubstitution of 3-aminobenzo[ c] and [ d]azepin-2-one 2 and 3 to afford potent and specific…”
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Parallel liquid synthesis of N, N′-Disubstituted 3-amino azepin-2-ones as potent and specific farnesyl transferase inhibitors by Le Diguarher, Thierry, Ortuno, Jean-Claude, Dorey, Gilbert, Shanks, David, Guilbaud, Nicolas, Pierré, Alain, Fauchère, Jean-Luc, Hickman, John A., Tucker, Gordon C., Casara, Patrick J.

“…A rapid structure–activity study was performed by parallel liquid synthesis on N, N′-disubstitution of 3-amino azepin-2-one to afford potent and specific…”
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General synthesis of α-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors by CHOLLET, Anne-Marie, LE DIGUARHER, Thierry, MURRAY, Lynne, BERTRAND, Marc, TUCKER, Gordon C, SABATINI, Massimo, PIERRE, Alain, ATASSI, Ghanem, BONNET, Jacqueline, CASARA, Patrick

“…Modulations of alpha and aryl substitutions on 3-aryloxy propionic acid hydroxamates led to novel and potent inhibitors of MMP-2,3,9 and 13, and selectivity…”
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Synthesis and physicochemical properties oligonucleotides built with either α-L or β-L nucleotides units and covalently linked to an acridine derivative by ASELINE, U, HAU, J.-F, CZENECKI, S, LE DIGUARHER, T, PERLAT, M.-C, VALERY, J.-M, NGUYEN THANH THUONG

“…Modified deoxynucleosides 2'-deoxy-beta-L-uridine, beta-L-thymidine, alpha-L-thymidine, 2'-deoxy-beta-L-adenosine and 2'-deoxy-alpha-L-adenosine were…”
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