Search Results - "Le Couteur, D. G."

Suicidal emperipolesis: a process leading to cell-in-cell structures, T cell clearance and immune homeostasis by Sierro, F, Tay, S S, Warren, A, Le Couteur, D G, McCaughan, G W, Bowen, D G, Bertolino, P

“…"Suicidal emperipolesis" is one of the most recently reported processes leading to cell-in-cell structures that promote cell death. This process was discovered…”
Get more information

Variability in Response to Medicines in Older People: Phenotypic and Genotypic Factors by MCLACHLAN, A. J, HILMER, S. N, LE COUTEUR, D. G

Get full text

Haem Iron Intake Is Associated with Increased Major Adverse Cardiovascular Events, All-Cause Mortality, Congestive Cardiac Failure, and Coronary Revascularisation in Older Men: The Concord Health and Ageing in Men Project by Luong, Rebecca, Ribeiro, R. V., Rangan, A., Naganathan, V., Blyth, F., Waite, L. M., Handelsman, D. J., Le Couteur, D. G., Seibel, M. J., Hirani, V.

“…Background Nutritional intake can influence major adverse cardiovascular events (MACE). Dietary iron is found in two forms: haem-iron (HI) only found in animal…”
Get full text

High‐Risk Prescribing and Incidence of Frailty Among Older Community‐Dwelling Men by Gnjidic, D, Hilmer, S N, Blyth, F M, Naganathan, V, Cumming, R G, Handelsman, D J, McLachlan, A J, Abernethy, D R, Banks, E, Le Couteur, D G

“…Evidence about the association between treatment with high–risk medicines and frailty in older individuals is limited. We investigated the relationship between…”
Get full text

Physicians need to take the lead in deprescribing by Scott, I. A., Le Couteur, D. G.

“…Inappropriate polypharmacy and its associated harm pose a significant threat to older patients. The prescribing decisions of physicians greatly influence what…”
Get full text

Circulating Sex Steroid Measurements of Men by Mass Spectrometry Are Highly Reproducible after Prolonged Frozen Storage by Handelsman, D.J., Desai, R., Seibel, M.J., Le Couteur, D.G., Cumming, R.G.

“…[Display omitted] •Reproducibility of steroid measurement in long-term frozen storage is crucial for long-term epidemiological research studies.•Using liquid…”
Get full text

Lifestyle factors, medications, and disease influence bone mineral density in older men: findings from the CHAMP study by Bleicher, K., Cumming, R. G., Naganathan, V., Seibel, M. J., Sambrook, P. N., Blyth, F. M., Le Couteur, D. G., Handelsman, D. J., Creasey, H. M., Waite, L. M.

“…Summary Aging alone is not the only factor accounting for poor bone health in older men. There are modifiable factors and lifestyle choices that may influence…”
Get full text

Frailty and Cause-Specific Hospitalizations in Community-Dwelling Older Men by Hsu, Benjamin, Naganathan, V., Blyth, F. M., Hirani, V., Le Couteur, D. G., Waite, L. M., Seibel, M. J., Handelsman, D. J., Cumming, R. G.

“…Objectives The types of medical conditions leading to hospitalization in frail older people have not been investigated. The objectives were to evaluate…”
Get full text

Pesticides and Parkinson's disease by Le Couteur, D.G., McLean, A.J., Taylor, M.C., Woodham, B.L., Board, P.G.

“…Epidemiological studies and case reports provide evidence for an association between Parkinson's disease and past exposure to pesticides. Susceptibility to the…”
Get full text

Does social support predict increased use of dental services in older men? by Shu, C‐C, Wright, FAC, Naganathan, V, Blyth, FM, Le Couteur, DG, Handelsman, DJ, Stanaway, FF

“…Background Past research on social support and dental visits in older people has been limited by cross‐sectional design, limited social support dimensions and…”
Get full text

Vitamin D status among older community dwelling men living in a sunny country and associations with lifestyle factors: The concord health and ageing in men project, Sydney, Australia by Hirani, Vasant, Cumming, R. G, Blyth, F. M, Naganathan, V, Le Couteur, D. G, Handelsman, D. J, Waite, L. M, Seibel, M. J

“…OBJECTIVES: Inadequate vitamin D status (25-hydroxyvitamin D (25(OH)D) concentrations <50 nmol/L) is an increasingly important public health issue in…”
Get full text

A randomized clinical trial of activated charcoal for the routine management of oral drug overdose by Cooper, G.M., Le Couteur, D.G., Richardson, D., Buckley, N.A.

“…Background: Activated charcoal (AC) is commonly used for the routine management of oral drug overdose. Aim: To determine whether the routine use of activated…”
Get full text

Oral health of community‐dwelling older Australian men: the Concord Health and Ageing in Men Project (CHAMP) by Wright, FAC, Chu, SK‐Y, Milledge, KL, Valdez, E, Law, G, Hsu, B, Naganathan, V, Hirani, V, Blyth, FM, Le Couteur, DG, Harford, J, Waite, LM, Handelsman, DJ, Seibel, MJ, Cumming, RG

“…Background The Concord Health and Ageing in Men Project (CHAMP) is a cohort study of the health of a representative sample of Australian men aged 70 years and…”
Get full text

Oral health behaviours of older Australian men: the Concord Health and Ageing in Men Project by Tran, J, Wright, FAC, Takara, S, Shu, C‐C, Chu, SK‐Y, Naganathan, V, Hirani, V, Blyth, FM, Le Couteur, DG, Waite, LM, Handelsman, DJ, Seibel, MJ, Milledge, KL, Cumming, RG

“…Background The Concord Health and Ageing in Men Project (CHAMP) is a cohort study of the health of a representative sample of older Australian men. The aim of…”
Get full text

The Cys282Tyr polymorphism in the HFE gene in Australian Parkinson's disease patients by Buchanan, D.D, Silburn, P.A, Chalk, J.B, Le Couteur, D.G, Mellick, G.D

“…Iron homeostasis is altered in Parkinson's disease (PD). The HFE protein is an important regulator of cellular iron homeostasis and variations within this gene…”
Get full text

Do medical courses adequately prepare interns for safe and effective prescribing in New South Wales public hospitals? by Hilmer, S. N., Seale, J. P., Le Couteur, D. G., Crampton, R., Liddle, C.

“…Aims: To assess ability of interns immediately before starting clinical practice in New South Wales (NSW) teaching hospitals to prescribe medications safely…”
Get full text

Glutathione transferase omega class polymorphisms in parkinson disease by WHITBREAD, A. K, MELLICK, G. D, SILBURN, P. A, LE COUTEUR, D. G, BOARD, P. G

Get full text

The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis by McCann, S.J, Pond, S.M, James, K.M, Le Couteur, D.G

“…We performed a case-control study to investigate the association of the poor metaboliser genotype of the cytochrome P450 2D6 gene with Parkinson's disease…”
Get full text

The monoamine oxidase B gene GT repeat polymorphism and Parkinson's disease in a Chinese population by MELLICK, G. D, BUCHANAN, D. D, SILBURN, P. A, CHAN, D. K. Y, LE COUTEUR, D. G, LAW, L. K, WOO, J, PANG, C. P

“…Monoamine oxidase B (MAOB) metabolises dopamine and activates neurotoxins known to induce parkinsonism in humans and primates. Therefore the MAOB gene (MAOB;…”
Get full text

Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes by Jamieson, H. A, Cogger, V. C, Twigg, S. M, McLennan, S. V, Warren, A, Cheluvappa, R, Hilmer, S. N, Fraser, R, de Cabo, R, Le Couteur, D. G

“…Aims/hypothesis Diabetes mellitus is associated with extensive vascular pathology, yet little is known about its long-term effects on liver sinusoidal…”
Get full text