Search Results - "Le Cesne, A."

Survival Benefit of the Surgical Management of Retroperitoneal Sarcoma in a Reference Center: A Nationwide Study of the French Sarcoma Group from the NetSarc Database by Bonvalot, S., Gaignard, E., Stoeckle, E., Meeus, P., Decanter, G., Carrere, S., Honore, C., Delhorme, J. B., Fau, M., Tzanis, D., Causeret, S., Gimbergues, P., Guillois, J. M., Meunier, B., Le Cesne, A., Ducimetiere, F., Toulmonde, M., Blay, J. Y.

“…Background Guidelines recommend that retroperitoneal sarcoma (RPS) be managed in a reference sarcoma center (RSC), but the benefit remains to be demonstrated…”
Get full text

Management and prognosis of malignant peripheral nerve sheath tumors: The experience of the French Sarcoma Group (GSF-GETO) by Valentin, T, Le Cesne, A, Ray-Coquard, I, Italiano, A, Decanter, G, Bompas, E, Isambert, N, Thariat, J, Linassier, C, Bertucci, F, Bay, J.O, Bellesoeur, A, Penel, N, Le Guellec, S, Filleron, T, Chevreau, C

“…Abstract Background Malignant peripheral nerve sheath tumors (MPNST) are a rare subtype of soft tissue sarcoma. They can arise in irradiated fields, in…”
Get full text

Final analysis of the randomized trial on imatinib as an adjuvant in localized gastrointestinal stromal tumors (GIST) from the EORTC Soft Tissue and Bone Sarcoma Group (STBSG), the Australasian Gastro-Intestinal Trials Group (AGITG), UNICANCER, French Sarcoma Group (FSG), Italian Sarcoma Group (ISG), and Spanish Group for Research on Sarcomas (GEIS) by Casali, P.G., Le Cesne, A., Velasco, A.P., Kotasek, D., Rutkowski, P., Hohenberger, P., Fumagalli, E., Judson, I.R., Italiano, A., Gelderblom, H., Penel, N., Hartmann, J.T., Duffaud, F., Goldstein, D., Martin-Broto, J., Gronchi, A., Wardelmann, E., Marréaud, S., Zalcberg, J.R., Litière, S., Blay, J.-Y.

“…In 2004, we started an intergroup randomized trial of adjuvant imatinib versus no further therapy after R0-R1 surgery in localized, high/intermediate-risk…”
Get full text

The treatment of desmoid tumors: a stepwise clinical approach by Bonvalot, S, Desai, A, Coppola, S, Le Péchoux, C, Terrier, P, Dômont, J, Le Cesne, A

“…Aggressive fibromatosis (AF) is a monoclonal proliferative disease but does not metastasize and does not dedifferentiate to a high-grade malignancy in case of…”
Get full text

Can we cure patients with abdominal Desmoplastic Small Round Cell Tumor? Results of a retrospective multicentric study on 100 patients by Honoré, C., Delhorme, J.B., Nassif, E., Faron, M., Ferron, G., Bompas, E., Glehen, O., Italiano, A., Bertucci, F., Orbach, D., Pocard, M., Quenet, F., Blay, J.Y., Carrere, S., Chevreau, C., Mir, O., Le Cesne, A.

“…Despite being associated with a very poor prognosis, long-term survivors across all series of Desmoplastic Small Round Cell Tumor (DSRCT) have been reported…”
Get full text

Retroperitoneal sarcomas: patterns of care at diagnosis, prognostic factors and focus on main histological subtypes: a multicenter analysis of the French Sarcoma Group by Toulmonde, M., Bonvalot, S., Méeus, P., Stoeckle, E., Riou, O., Isambert, N., Bompas, E., Jafari, M., Delcambre-Lair, C., Saada, E., Le Cesne, A., Le Péchoux, C., Blay, J.Y., Piperno-Neumann, S., Chevreau, C., Bay, J.O., Brouste, V., Terrier, P., Ranchère-Vince, D., Neuville, A., Italiano, A.

“…Retroperitoneal sarcomas (RPS) are heterogeneous. No previous study has investigated the impact of specialized surgery, evaluated locoregional relapse (LRR),…”
Get full text

Doxorubicin-based adjuvant chemotherapy in soft tissue sarcoma: pooled analysis of two STBSG-EORTC phase III clinical trials by Le Cesne, A., Ouali, M., Leahy, M.G., Santoro, A., Hoekstra, H.J., Hohenberger, P., Van Coevorden, F., Rutkowski, P., Van Hoesel, R., Verweij, J., Bonvalot, S., Steward, W.P., Gronchi, A., Hogendoorn, P.C.W., Litiere, S., Marreaud, S., Blay, J.Y., Van Der Graaf, W.T.A.

“…The EORTC-STBSG coordinated two large trials of adjuvant chemotherapy (CT) in localized high-grade soft tissue sarcoma (STS). Both studies failed to…”
Get full text

Advanced well-differentiated/dedifferentiated liposarcomas: role of chemotherapy and survival by Italiano, A., Toulmonde, M., Cioffi, A., Penel, N., Isambert, N., Bompas, E., Duffaud, F., Patrikidou, A., Lortal, B., Le Cesne, A., Blay, J.-Y., Maki, R.G., Schwartz, G.K., Antonescu, C.R., Singer, S., Coindre, J.-M., Bui, B.

“…Data regarding the role of systemic therapy in patients with advanced well-differentiated/dedifferentiated liposarcomas (WDLPS/DDLPS) are limited. From 2000 to…”
Get full text

CSPG4 expression in soft tissue sarcomas is associated with poor prognosis and low cytotoxic immune response by Boudin, Laurys, de Nonneville, A, Finetti, Pascal, Mescam, Léna, Le Cesne, A, Italiano, Antoine, Blay, Jean-Yves, Birnbaum, Daniel, Mamessier, Emilie, Bertucci, François

“…Abstract Background Soft tissue sarcomas (STS) are heterogeneous and pro-metastatic tumors. Identification of accurate prognostic factors and novel therapeutic…”
Get full text

Efficacy of trabectedin in malignant solitary fibrous tumors: a retrospective analysis from the French Sarcoma Group by Khalifa, J, Ouali, M, Chaltiel, L, Le Guellec, S, Le Cesne, A, Blay, J-Y, Cousin, P, Chaigneau, L, Bompas, E, Piperno-Neumann, S, Bui-Nguyen, B, Rios, M, Delord, J-P, Penel, N, Chevreau, C

“…Advanced malignant solitary fibrous tumors (SFTs) are rare soft-tissue sarcomas with a poor prognosis. Several treatment options have been reported, but with…”
Get full text

Long-Term Outcome After Surgery for a Localized Retroperitoneal Soft Tissue Sarcoma in Elderly Patients: Results from a Retrospective, Single-Center Study by Sourrouille, I., Macovei, R., Faron, M., Le Péchoux, C., Mir, O., Adam, J., Dumont, S., Terrier, P., Le Cesne, A., Honoré, C.

“…Background To evaluate short- and long-term results after curative surgery for a retroperitoneal sarcoma (RPS) in elderly patients. Methods We retrospectively…”
Get full text

Systemic treatment in advanced phyllodes tumor of the breast: a multi-institutional European retrospective case-series analyses by Palassini, E., Mir, O., Grignani, G., Vincenzi, B., Gelderblom, H., Sebio, A., Valverde, C., Baldi, G. G., Brunello, A., Cardellino, G. G., Marrari, A., Badalamenti, G., Martin-Broto, J., Ferraresi, V., Libertini, M., Turano, S., Gataa, I., Collini, P., Tos, A. P. Dei, Gennaro, M., Bini, F., Provenzano, S., Vullo, S. Lo, Mariani, L., Le Cesne, A., Casali, P. G.

“…Background We aimed at investigating outcome of systemic treatments in advanced breast PT. Methods All cases of advanced breast PT treated with systemic…”
Get full text

Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: a multivariate analysis of the French Sarcoma Group Database by Italiano, A., Delva, F., Mathoulin-Pelissier, S., Le Cesne, A., Bonvalot, S., Terrier, P., Trassard, M., Michels, J.-J., Blay, J.-Y., Coindre, J.-M., Bui, B.

“…The predictive value of grade for benefit from adjuvant chemotherapy (AC) in soft tissue sarcoma (STS) patients has never been explored. From 1980 to 1999,…”
Get full text

Specific immune landscapes and immune checkpoint expressions in histotypes and molecular subtypes of sarcoma by Dufresne, A., Lesluyes, T., Ménétrier-Caux, C., Brahmi, M., Darbo, E., Toulmonde, M., Italiano, A., Mir, O., Le Cesne, A., Le Guellec, S., Valentin, T., Chevreau, C., Bonvalot, S., Robin, Y.M., Coindre, J-M, Caux, C., Blay, J.Y., Chibon, F.

“…Soft tissue sarcomas are a group of rare and aggressive connective tissue neoplasms for which curative therapeutic opportunities are limited in advanced phase…”
Get full text

Impact of surgery on advanced gastrointestinal stromal tumors (GIST) in the imatinib era by Bonvalot, S, Eldweny, H, Péchoux, C Le, Vanel, D, Terrier, P, Cavalcanti, A, Robert, C, Lassau, N, Cesne, A Le

“…The role for surgery in patients with "unresectable" gastrointestinal stromal tumors (GIST) treated with imatinib is still not defined. The objective of this…”
Get full text

Phase II Study of ET-743 in Advanced Soft Tissue Sarcomas: A European Organisation for the Research and Treatment of Cancer (EORTC) Soft Tissue and Bone Sarcoma Group Trial by LE CESNE, A, BLAY, J. Y, COLLIN, F, JIMENO, J, DI PAOLA, E, VAN GLABBEKE, M, NIELSEN, O. S, JUDSON, I, VAN OOSTEROM, A, VERWEIJ, J, RADFORD, J, LORIGAN, P, RODENHUIS, S, RAY-COQUARD, I, BONVALOT, S

“…This nonrandomized multicenter phase II study was performed to evaluate the activity and safety of Ecteinascidin (ET-743) administered at a dose of 1.5 mg/m(2)…”
Get full text

Sporadic desmoid-type fibromatosis: a stepwise approach to a non-metastasising neoplasm—a position paper from the Italian and the French Sarcoma Group by Gronchi, A., Colombo, C., Le Péchoux, C., Dei Tos, A.P., Le Cesne, A., Marrari, A., Penel, N., Grignani, G., Blay, J.Y., Casali, P.G., Stoeckle, E., Gherlinzoni, F., Meeus, P., Mussi, C., Gouin, F., Duffaud, F., Fiore, M., Bonvalot, S.

“…Desmoid-type fibromatosis (DF) is a rare locally aggressive monoclonal proliferation of myofibroblasts lacking metastatic capacity. It may be observed in…”
Get full text

Natural history and treatment efficacy in an ambispective case series of NTRK-rearranged mesenchymal tumors by Dufresne, A., Pissaloux, D., Ngo, C., Penel, N., Le Cesne, A., Macagno, N., Vanacker, H., Hénon, C., Jean-Denis, M., Rughoo, K., Tirode, F., Blay, J.-Y., Brahmi, M.

“…Apart for infantile fibrosarcoma (IFS), very little is known about NTRK-rearranged mesenchymal tumors (NMTs). The objective of this study is to describe the…”
Get full text

Toward a new strategy in desmoid of the breast? by Roussin, S, Mazouni, C, Rimareix, F, Honoré, C, Terrier, P, Mir, O, Dômont, J, Le Péchoux, C, Le Cesne, A, Bonvalot, S

“…Abstract Aim To report initial results of observation as well as surgery in patients with desmoid tumors (DTs) of the breast, a rare tumor for which data are…”
Get full text

First-line chemotherapy for malignant peripheral nerve sheath tumor (MPNST) versus other histological soft tissue sarcoma subtypes and as a prognostic factor for MPNST: an EORTC Soft Tissue and Bone Sarcoma Group study by Kroep, J.R., Ouali, M., Gelderblom, H., Le Cesne, A., Dekker, T.J.A., Van Glabbeke, M., Hogendoorn, P.C.W., Hohenberger, P.

“…Background: The role of chemotherapy in advanced malignant peripheral nerve sheath tumor (MPNST) is unclear. Patients and methods: Chemotherapy-naive soft…”
Get full text