Search Results - "Le Cam, Eric"

Changes in the architecture and abundance of replication intermediates delineate the chronology of DNA damage tolerance pathways at UV-stalled replication forks in human cells by Benureau, Yann, Pouvelle, Caroline, Dupaigne, Pauline, Baconnais, Sonia, Moreira Tavares, Eliana, Mazón, Gerard, Despras, Emmanuelle, Le Cam, Eric, Kannouche, Patricia L

“…Abstract DNA lesions in S phase threaten genome stability. The DNA damage tolerance (DDT) pathways overcome these obstacles and allow completion of DNA…”
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Verotoxin-1-Induced ER Stress Triggers Apoptotic or Survival Pathways in Burkitt Lymphoma Cells by Debernardi, Justine, Pioche-Durieu, Catherine, Cam, Eric Le, Wiels, Joëlle, Robert, Aude

“…Shiga toxins (Stxs) expressed by the enterohaemorrhagic and enteric pathogens are protein synthesis inhibitors. Stxs have been shown to induce apoptosis via…”
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Rad52-Rad51 association is essential to protect Rad51 filaments against Srs2, but facultative for filament formation by Ma, Emilie, Dupaigne, Pauline, Maloisel, Laurent, Guerois, Raphaël, Le Cam, Eric, Coïc, Eric

“…Homology search and strand exchange mediated by Rad51 nucleoprotein filaments are key steps of the homologous recombination process. In budding yeast, Rad52 is…”
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Sepiolite as a New Nanocarrier for DNA Transfer into Mammalian Cells: Proof of Concept, Issues and Perspectives by Piétrement, Olivier, Castro‐Smirnov, Fidel Antonio, Le Cam, Eric, Aranda, Pilar, Ruiz‐Hitzky, Eduardo, Lopez, Bernard S.

“…Sepiolite is a nanofibrous natural silicate that can be used as a nanocarrier for DNA transfer thanks to its strong interaction with DNA molecules and its…”
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High-resolution AFM imaging of single-stranded DNA-binding (SSB) protein--DNA complexes by Hamon, Loïc, Pastré, David, Dupaigne, Pauline, Breton, Cyrille Le, Cam, Eric Le, Piétrement, Olivier

“…DNA in living cells is generally processed via the generation and the protection of single-stranded DNA involving the binding of ssDNA-binding proteins (SSBs)…”
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Rad52 sumoylation prevents the toxicity of unproductive Rad51 filaments independently of the anti-recombinase Srs2 by Esta, Aline, Ma, Emilie, Dupaigne, Pauline, Maloisel, Laurent, Guerois, Raphaël, Le Cam, Eric, Veaute, Xavier, Coïc, Eric

“…The budding yeast Srs2 is the archetype of helicases that regulate several aspects of homologous recombination (HR) to maintain genomic stability. Srs2…”
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Linker Histones Incorporation Maintains Chromatin Fiber Plasticity by Recouvreux, Pierre, Lavelle, Christophe, Barbi, Maria, Conde e Silva, Natalia, Le Cam, Eric, Victor, Jean-Marc, Viovy, Jean-Louis

“…Genomic DNA in eukaryotic cells is organized in supercoiled chromatin fibers, which undergo dynamic changes during such DNA metabolic processes as…”
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Rouse model with transient intramolecular contacts on a timescale of seconds recapitulates folding and fluctuation of yeast chromosomes by Socol, Marius, Wang, Renjie, Jost, Daniel, Carrivain, Pascal, Vaillant, Cédric, Le Cam, Eric, Dahirel, Vincent, Normand, Christophe, Bystricky, Kerstin, Victor, Jean-Marc, Gadal, Olivier, Bancaud, Aurélien

“…Abstract DNA folding and dynamics along with major nuclear functions are determined by chromosome structural properties, which remain, thus far, elusive in…”
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The universal Kae1 protein and the associated Bud32 kinase (PRPK), a mysterious protein couple probably essential for genome maintenance in Archaea and Eukarya by Hecker, Arnaud, Graille, Marc, Madec, Edwige, Gadelle, Danièle, Le Cam, Eric, van Tilbergh, Herman, Forterre, Patrick

“…The similarities between essential molecular mechanisms in Archaea and Eukarya make it possible to discover, using comparative genomics, new fundamental…”
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In vitro role of Rad54 in Rad51-ssDNA filament-dependent homology search and synaptic complexes formation by Tavares, Eliana Moreira, Wright, William Douglass, Heyer, Wolf-Dietrich, Le Cam, Eric, Dupaigne, Pauline

“…Homologous recombination (HR) uses a homologous template to accurately repair DNA double-strand breaks and stalled replication forks to maintain genome…”
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The EcoRI−DNA Complex as a Model for Investigating Protein−DNA Interactions by Atomic Force Microscopy by Sorel, Isabelle, Piétrement, Olivier, Hamon, Loïc, Baconnais, Sonia, Le Cam, Eric, Pastré, David

“…Atomic force microscopy (AFM) is a technique widely used to image protein−DNA complexes, and its application has now been extended to the measurements of…”
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Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer by Berchem, Guy, Noman, Muhammad Zaeem, Bosseler, Manon, Paggetti, Jerome, Baconnais, Sonia, Le cam, Eric, Nanbakhsh, Arash, Moussay, Etienne, Mami-Chouaib, Fathia, Janji, Bassam, Chouaib, Salem

“…Tumor-derived microvesicles (TD-MVs) are key mediators which are shed by cancer cells and can sensitize neighboring cells in the tumor microenvironment. TD-MVs…”
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XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining by Nemoz, Clement, Ropars, Virginie, Frit, Philippe, Gontier, Amandine, Drevet, Pascal, Yu, Jinchao, Guerois, Raphaël, Pitois, Aurelien, Comte, Audrey, Delteil, Christine, Barboule, Nadia, Legrand, Pierre, Baconnais, Sonia, Yin, Yandong, Tadi, Satish, Barbet-Massin, Emeline, Berger, Imre, Le Cam, Eric, Modesti, Mauro, Rothenberg, Eli, Calsou, Patrick, Charbonnier, Jean Baptiste

“…The Ku70–Ku80 (Ku) heterodimer binds rapidly and tightly to the ends of DNA double-strand breaks and recruits factors of the non-homologous end-joining (NHEJ)…”
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RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic function by So, Ayeong, Dardillac, Elodie, Muhammad, Ali, Chailleux, Catherine, Sesma-Sanz, Laura, Ragu, Sandrine, Le Cam, Eric, Canitrot, Yvan, Masson, Jean Yves, Dupaigne, Pauline, Lopez, Bernard S, Guirouilh-Barbat, Josée

“…Abstract Selection of the appropriate DNA double-strand break (DSB) repair pathway is decisive for genetic stability. It is proposed to act according to two…”
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Study of the DnaB:DciA interplay reveals insights into the primary mode of loading of the bacterial replicative helicase by Marsin, Stéphanie, Adam, Yazid, Cargemel, Claire, Andreani, Jessica, Baconnais, Sonia, Legrand, Pierre, Li de la Sierra-Gallay, Ines, Humbert, Adeline, Aumont-Nicaise, Magali, Velours, Christophe, Ochsenbein, Françoise, Durand, Dominique, Le Cam, Eric, Walbott, Hélène, Possoz, Christophe, Quevillon-Cheruel, Sophie, Ferat, Jean-Luc

“…Abstract Replicative helicases are essential proteins that unwind DNA in front of replication forks. Their loading depends on accessory proteins and in…”
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Assembly mechanism and cryoEM structure of RecA recombination nucleofilaments from Streptococcus pneumoniae by Hertzog, Maud, Perry, Thomas Noé, Dupaigne, Pauline, Serres, Sandra, Morales, Violette, Soulet, Anne-Lise, Bell, Jason C, Margeat, Emmanuel, Kowalczykowski, Stephen C, Le Cam, Eric, Fronzes, Rémi, Polard, Patrice

“…Abstract RecA-mediated homologous recombination (HR) is a key mechanism for genome maintenance and plasticity in bacteria. It proceeds through RecA assembly…”
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Structural analysis of the Candida albicans mitochondrial DNA maintenance factor Gcf1p reveals a dynamic DNA-bridging mechanism by Tarrés-Solé, Aleix, Battistini, Federica, Gerhold, Joachim M, Piétrement, Olivier, Martínez-García, Belén, Ruiz-López, Elena, Lyonnais, Sébastien, Bernadó, Pau, Roca, Joaquim, Orozco, Modesto, Le Cam, Eric, Sedman, Juhan, Solà, Maria

“…Abstract The compaction of mitochondrial DNA (mtDNA) is regulated by architectural HMG-box proteins whose limited cross-species similarity suggests diverse…”
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In vivo reduction of RAD51-mediated homologous recombination triggers aging but impairs oncogenesis by Matos-Rodrigues, Gabriel, Barroca, Vilma, Muhammad, Ali-Akbar, Dardillac, Elodie, Allouch, Awatef, Koundrioukoff, Stephane, Lewandowski, Daniel, Despras, Emmanuelle, Guirouilh-Barbat, Josée, Frappart, Lucien, Kannouche, Patricia, Dupaigne, Pauline, Le Cam, Eric, Perfettini, Jean-Luc, Romeo, Paul-Henri, Debatisse, Michelle, Jasin, Maria, Livera, Gabriel, Martini, Emmanuelle, Lopez, Bernard S

“…Homologous recombination (HR) is a prominent DNA repair pathway maintaining genome integrity. Mutations in many HR genes lead to cancer predisposition…”
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Auto-assembly as a new regulatory mechanism of noncoding RNA by Busi, Florent, Cayrol, Bastien, Lavelle, Christophe, LeDerout, Jacques, Piétrement, Olivier, Le Cam, Eric, Geinguenaud, Frédéric, Lacoste, Jérôme, Régnier, Philippe, Arluison, Véronique

“…An abstract is not available for this article…”
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C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair by McGovern, Stephen, Baconnais, Sonia, Roblin, Pierre, Nicolas, Pierre, Drevet, Pascal, Simonson, Héloïse, Piétrement, Olivier, Charbonnier, Jean-Baptiste, Le Cam, Eric, Noirot, Philippe, Lecointe, François

“…Non-homologous end joining is a ligation process repairing DNA double strand breaks in eukaryotes and many prokaryotes. The ring structured eukaryotic Ku binds…”
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