Search Results - "Le Brun, Nick E."

Nitrosylation of Nitric-Oxide-Sensing Regulatory Proteins Containing [4Fe-4S] Clusters Gives Rise to Multiple Iron-Nitrosyl Complexes by Serrano, Pauline N., Wang, Hongxin, Crack, Jason C., Prior, Christopher, Hutchings, Matthew I., Thomson, Andrew J., Kamali, Saeed, Yoda, Yoshitaka, Zhao, Jiyong, Hu, Michael Y., Alp, Ercan E., Oganesyan, Vasily S., Le Brun, Nick E., Cramer, Stephen P.

“…The reaction of protein‐bound iron–sulfur (Fe‐S) clusters with nitric oxide (NO) plays key roles in NO‐mediated toxicity and signaling. Elucidation of the…”
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Mechanisms of iron- and O2-sensing by the [4Fe-4S] cluster of the global iron regulator RirA by Pellicer Martinez, Ma Teresa, Crack, Jason C, Stewart, Melissa YY, Bradley, Justin M, Svistunenko, Dimitri A, Johnston, Andrew WB, Cheesman, Myles R, Todd, Jonathan D, Le Brun, Nick E

“…RirA is a global regulator of iron homeostasis in Rhizobium and related α-proteobacteria. In its [4Fe-4S] cluster-bound form it represses iron uptake by…”
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The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster by Tucker, Nicholas P, Hicks, Matthew G, Clarke, Thomas A, Crack, Jason C, Chandra, Govind, Le Brun, Nick E, Dixon, Ray, Hutchings, Matthew I

“…The regulatory protein NsrR, a member of the Rrf2 family of transcription repressors, is specifically dedicated to sensing nitric oxide (NO) in a variety of…”
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High Cu(I) and low proton affinities of the CXXC motif of Bacillus subtilis CopZ by Zhou, Liang, Singleton, Chloe, Le Brun, Nick E

“…CopZ, an Atx1-like copper chaperone from the bacterium Bacillus subtilis, functions as part of a complex cellular machinery for Cu(I) trafficking and…”
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Iron–Sulfur Clusters as Biological Sensors: The Chemistry of Reactions with Molecular Oxygen and Nitric Oxide by Crack, Jason C, Green, Jeffrey, Thomson, Andrew J, Brun, Nick E. Le

“…Conspectus Iron–sulfur cluster proteins exhibit a range of physicochemical properties that underpin their functional diversity in biology, which includes roles…”
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Mass Spectrometric Identification of [4Fe–4S](NO)x Intermediates of Nitric Oxide Sensing by Regulatory Iron–Sulfur Cluster Proteins by Crack, Jason C., Le Brun, Nick E.

“…Nitric oxide (NO) can function as both a cytotoxin and a signalling molecule. In both cases, reaction with iron–sulfur (Fe–S) cluster proteins plays an…”
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Influence of association state and DNA binding on the O₂-reactivity of [4Fe-4S] fumarate and nitrate reduction (FNR) regulator by Crack, Jason C, Stapleton, Melanie R, Green, Jeffrey, Thomson, Andrew J, Le Brun, Nick E

“…The fumarate and nitrate reduction (FNR) regulator is the master switch for the transition between anaerobic and aerobic respiration in Escherichia coli…”
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Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding by Volbeda, Anne, Dodd, Erin L., Darnault, Claudine, Crack, Jason C., Renoux, Oriane, Hutchings, Matthew I., Le Brun, Nick E., Fontecilla-Camps, Juan C.

“…NsrR from Streptomyces coelicolor ( Sc) regulates the expression of three genes through the progressive degradation of its [4Fe–4S] cluster on nitric oxide…”
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Insights into methionine S-methylation in diverse organisms by Peng, Ming, Li, Chun-Yang, Chen, Xiu-Lan, Williams, Beth T., Li, Kang, Gao, Ya-Nan, Wang, Peng, Wang, Ning, Gao, Chao, Zhang, Shan, Schoelmerich, Marie C., Banfield, Jillian F., Miller, J. Benjamin, Le Brun, Nick E., Todd, Jonathan D., Zhang, Yu-Zhong

“…Dimethylsulfoniopropionate (DMSP) is an important marine anti-stress compound, with key roles in global nutrient cycling, chemotaxis and, potentially, climate…”
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Reversible cycling between cysteine persulfide-ligated [2Fe-2S] and cysteine-ligated [4Fe-4S] clusters in the FNR regulatory protein by Zhang, Bo, Crack, Jason C, Subramanian, Sowmya, Green, Jeffrey, Thomson, Andrew J, Le Brun, Nick E, Johnson, Michael K

“…Fumarate and nitrate reduction (FNR) regulatory proteins are O ₂-sensing bacterial transcription factors that control the switch between aerobic and anaerobic…”
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Structure and Cu(I)-binding properties of the N-terminal soluble domains of Bacillus subtilis CopA by Singleton, Chloe, Banci, Lucia, Ciofi-Baffoni, Simone, Tenori, Leonardo, Kihlken, Margaret A, Boetzel, Ruth, Le Brun, Nick E

“…CopA, a P-type ATPase from Bacillus subtilis, plays a major role in the resistance of the cell to copper by effecting the export of the metal across the…”
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Structure of a Wbl protein and implications for NO sensing by M. tuberculosis by Kudhair, Bassam K., Hounslow, Andrea M., Rolfe, Matthew D., Crack, Jason C., Hunt, Debbie M., Buxton, Roger S., Smith, Laura J., Le Brun, Nick E., Williamson, Michael P., Green, Jeffrey

“…Mycobacterium tuberculosis causes pulmonary tuberculosis (TB) and claims ~1.8 million human lives per annum. Host nitric oxide (NO) is important in controlling…”
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Structural Basis for Iron Mineralization by Bacterioferritin by Crow, Allister, Lawson, Tamara L, Lewin, Allison, Moore, Geoffrey R, Brun, Nick E. Le

“…Ferritin proteins function to detoxify, solubilize and store cellular iron by directing the synthesis of a ferric oxyhydroxide mineral solubilized within the…”
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Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster by Smith, Laura J, Stapleton, Melanie R, Fullstone, Gavin J M, Crack, Jason C, Thomson, Andrew J, Le Brun, Nick E, Hunt, Debbie M, Harvey, Evelyn, Adinolfi, Salvatore, Buxton, Roger S, Green, Jeffrey

“…Mycobacterium tuberculosis is a major pathogen that has the ability to establish, and emerge from, a persistent state. Wbl family proteins are associated with…”
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Iron core mineralisation in prokaryotic ferritins by Le Brun, Nick E., Crow, Allister, Murphy, Michael E.P., Mauk, A. Grant, Moore, Geoffrey R.

“…To satisfy their requirement for iron while at the same time countering the toxicity of this highly reactive metal ion, prokaryotes have evolved proteins…”
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Three Aromatic Residues are Required for Electron Transfer during Iron Mineralization in Bacterioferritin by Bradley, Justin M., Svistunenko, Dimitri A., Lawson, Tamara L., Hemmings, Andrew M., Moore, Geoffrey R., Le Brun, Nick E.

“…Ferritins are iron storage proteins that overcome the problems of toxicity and poor bioavailability of iron by catalyzing iron oxidation and mineralization…”
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Binding of IscU and TusA to different but competing sites of IscS influences the activity of IscS and directs sulfur to the respective biomolecular synthesis pathway by Olivieri, Paolo, Klabes, Moritz, Crack, Jason C, Lehmann, Angelika, Bennett, Sophie P, Le Brun, Nick E, Leimkühler, Silke

“…All sulfur transfer pathways generally have in common an l-cysteine desulfurase as the initial sulfur-mobilizing enzyme, which serves as a sulfur donor for the…”
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Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence by Smith, Laura J, Bochkareva, Aleksandra, Rolfe, Matthew D, Hunt, Debbie M, Kahramanoglou, Christina, Braun, Yvonne, Rodgers, Angela, Blockley, Alix, Coade, Stephen, Lougheed, Kathryn E A, Hafneh, Nor Azian, Glenn, Sarah M, Crack, Jason C, Le Brun, Nick E, Saldanha, José W, Makarov, Vadim, Nobeli, Irene, Arnvig, Kristine, Mukamolova, Galina V, Buxton, Roger S, Green, Jeffrey

“…Mycobacterium tuberculosis (MTb) is the causative agent of pulmonary tuberculosis (TB). MTb colonizes the human lung, often entering a non-replicating state…”
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Structural determinants of DNA recognition by the NO sensor NsrR and related Rrf2-type [FeS]-transcription factors by Rohac, Roman, Crack, Jason C., de Rosny, Eve, Gigarel, Océane, Le Brun, Nick E., Fontecilla-Camps, Juan C., Volbeda, Anne

“…Several transcription factors of the Rrf2 family use an iron-sulfur cluster to regulate DNA binding through effectors such as nitric oxide (NO), cellular redox…”
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Probing the Reactivity of [4Fe-4S] Fumarate and Nitrate Reduction (FNR) Regulator with O2 and NO: Increased O2 Resistance and Relative Specificity for NO of the [4Fe-4S] L28H FNR Cluster by Crack, Jason C., Amara, Patricia, de Rosny, Eve, Darnault, Claudine, Stapleton, Melanie R., Green, Jeffrey, Volbeda, Anne, Fontecilla-Camps, Juan C., Le Brun, Nick E.

“…The Escherichia coli fumarate and nitrate reduction (FNR) regulator acts as the cell’s master switch for the transition between anaerobic and aerobic…”
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