Search Results - "Le Blanc, K"

Immunomodulation by mesenchymal stem cells and clinical experience by Le Blanc, K., Ringdén, O.

“…Mesenchymal stem cells (MSCs) from adult marrow can differentiate in vitro and in vivo into various cell types, such as bone, fat and cartilage. MSCs…”
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Analysis of Tissues Following Mesenchymal Stromal Cell Therapy in Humans Indicates Limited Long-Term Engraftment and No Ectopic Tissue Formation by von Bahr, L., Batsis, I., Moll, G., Hägg, M., Szakos, A., Sundberg, B., Uzunel, M., Ringden, O., Le Blanc, K.

“…Mesenchymal stromal cells (MSCs) are explored as a novel treatment for a variety of medical conditions. Their fate after infusion is unclear, and long‐term…”
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Immunomodulatory effects of fetal and adult mesenchymal stem cells by Le Blanc, K.

“…Mesenchymal stem cells (MSC) derived from adult BM or fetal liver form several mesenchymal tissues after appropriate stimulation. Reports indicate that MSC…”
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Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells by LE BLANC, K, SAMUELSSON, H, GUSTAFSSON, B, REMBERGER, M, SUNDBERG, B, ARVIDSON, J, LJUNGMAN, P, LÖNNIES, H, NAVA, S, RINGDEN, O

“…Seven patients underwent treatment with mesenchymal stem cells (MSCs), together with allogeneic hematopoietic stem cell transplantation (HSCT). MSCs were given…”
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Mesenchymal stromal cells: tissue repair and immune modulation by Le Blanc, K.

“…BM-derived mesenchymal stromal cells (MSC) differentiate along the mesenchymal lineage to bone, fat and cartilage. In vitro, MSC induce little, if any,…”
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Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement by Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F.C, Krause, D.S., Deans, R.J., Keating, A., Prockop, D.J., Horwitz, E.M.

“…The considerable therapeutic potential of human multipotent mesenchymal stromal cells (MSC) has generated markedly increasing interest in a wide variety of…”
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Mesenchymal Stem Cells Inhibit and Stimulate Mixed Lymphocyte Cultures and Mitogenic Responses Independently of the Major Histocompatibility Complex by Le Blanc, K., Tammik, L., Sundberg, B., Haynesworth, S. E., Ringdén, O.

“…We aimed to study the effects of mesenchymal stem cells (MSCs) on alloreactivity and effects of T‐cell activation on human peripheral blood lymphocytes (PBLs)…”
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Mesenchymal Stem Cells Stimulate Antibody Secretion in Human B Cells by Rasmusson, I, Le Blanc, K, Sundberg, B, Ringdén, O

“…Mesenchymal stem cells (MSC) have immunomodulatory effects and inhibit T-cell responses to alloantigens and mitogens in vitro and in vivo. We wanted to examine…”
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Immunosuppressive CD14+HLA-DRlow/neg IDO+ myeloid cells in patients following allogeneic hematopoietic stem cell transplantation by Mougiakakos, D, Jitschin, R, von Bahr, L, Poschke, I, Gary, R, Sundberg, B, Gerbitz, A, Ljungman, P, Le Blanc, K

“…Myeloid-derived suppressor cells (MDSCs) have emerged as a heterogeneic immunoregulatory population that can expand in response to inflammatory signals…”
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Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement by Horwitz, E.M., Le Blanc, K., Dominici, M., Mueller, I., Slaper-Cortenbach, I., Marini, F.C., Deans, R.J., Krause, D.S., Keating, A.

“…The plastic-adherent cells isolated from BM and other sources have come to be widely known as mesenchymal stem cells (MSC). However, the recognized biologic…”
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Mesenchymal stem cells for treatment of acute and chronic graft-versus-host disease, tissue toxicity and hemorrhages by Ringden, O., MD, PhD, Le Blanc, K., MD, PhD

“…Mesenchymal stem cells (MSCs) have immunomodulatory effects and low immunogenicity. MSCs inhibit T-cell alloreactivity in vitro . Immune inhibition is caused…”
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Increased incidence of chronic GvHD and CMV disease in patients with vitamin D deficiency before allogeneic stem cell transplantation by von Bahr, L, Blennow, O, Alm, J, Björklund, A, Malmberg, K-J, Mougiakakos, D, Le Blanc, A, Oefner, P J, Labopin, M, Ljungman, P, Le Blanc, K

“…Vitamin D has emerged as a central player in the immune system, with its deficiency being implicated in the pathogenesis of several autoimmune diseases,…”
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Mesenchymal Stem Cells Inhibit the Expression of CD25 (Interleukin‐2 Receptor) and CD38 on Phytohaemagglutinin‐Activated Lymphocytes by Le Blanc, K., Rasmusson, I., Götherström, C., Seidel, C., Sundberg, B., Sundin, M., Rosendahl, K., Tammik, C., Ringdén, O.

“…Mesenchymal stem cells (MSC) are immunomodulatory and inhibit lymphocyte proliferation. We studied surface expression of lymphocyte activation markers and…”
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Quantitative chromogenic immunohistochemical image analysis in cellprofiler software by Tollemar, V., Tudzarovski, N., Boberg, E., Törnqvist Andrén, A., Al‐Adili, A., Le Blanc, K., Garming Legert, K., Bottai, M., Warfvinge, G., Sugars, R.V.

“…Visual grading of chromogenically stained immunohistochemical (IHC) samples is subjective, time consuming, and predisposed to considerable inter‐ and…”
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No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients by Sundin, Mikael, Ringden, Olle, Sundberg, Berit, Nava, Silvia, Gotherstrom, Cecilia, Le Blanc, Katarina

“…From the Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet, SE-141 86 Stockholm, Sweden (MS, OR, BS, SN, CG, KLB);…”
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Mesenchymal stem cells: progress toward promise by Le Blanc, K., Pittenger, M. F.

“…Despite having access to embryonic stem cells, many laboratories choose to study adult stem cells, not because of philosophical reasons but because of the…”
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Immunotherapy prospects for acute myeloid leukaemia by Barrett, A.J, Le Blanc, K

“…While chemotherapy is successful at inducing remission of acute myeloid leukaemia (AML), the disease has a high probability of relapse. Strategies to prevent…”
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Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon by RINGDEN, O, UZUNEL, M, SUNDBERG, B, LÖNNIES, L, NAVA, S, GUSTAFSSON, J, HENNINGSOHN, L, LE BLANC, K

“…Mesenchymal stem cells (MSC) possess anti-inflammatory properties and participate in tissue repair. We used MSC to heal therapy-induced tissue toxicity. Ten…”
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Co-infusion of ex vivo-expanded, parental MSCs prevents life-threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation by Bernardo, M E, Ball, L M, Cometa, A M, Roelofs, H, Zecca, M, Avanzini, M A, Bertaina, A, Vinti, L, Lankester, A, Maccario, R, Ringden, O, Le Blanc, K, Egeler, R M, Fibbe, W E, Locatelli, F

“…When compared with BMT, umbilical cord blood transplantation (UCBT) is associated with a lower rate of engraftment and delayed hematological/immunological…”
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Grading of minor salivary gland immuno-histopathology post-allogenic hematopoietic cell transplantation by Tollemar, V., Arvidsson, H., Häbel, H., Tudzarovski, N., Legert, K. Garming, Le Blanc, K., Warfvinge, G., Sugars, R.V.

“…The oral cavity commonly displays mucosal lichenoid lesions and salivary gland dysfunction, which are considered different chronic Graft-versus-Host Disease…”
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