Search Results - "Le Bars, Joel"

Control of Hydrogen Fluoride Formation and Release during a Large-Scale Nitroarene Reduction in the Manufacture of AZD9977 by Mallia, Carl J., Le Bars, Joël, Hardy, Simon, Lamacraft, Alex, Harding, Simon, Hose, David, Snow, Lindsay, Poulten, Rebecca C., Dobson, Benjamin C., Churchill, Trevor, Gillespie, Paul M.

“…A nitroarene reduction process was developed to run on a multi-kilo scale with optimized conditions to reduce the formation of hydrogen fluoride through…”
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Development and Manufacture of a Curtius Rearrangement Using Continuous Flow towards the Large-Scale Manufacture of AZD7648 by Mallia, Carl J., McCreanor, Niall G., Legg, Daniel H., Stewart, Craig R., Coppock, Sarah, Ashworth, Ian W., Le Bars, Joël, Clarke, Adam, Clemens, Graeme, Fisk, Heidi, Benson, Helen, Oke, Samantha, Churchill, Trevor, Hoyle, Mark, Timms, Lee, Vare, Kevin, Sims, Martin, Knight, Steven

“…Flow chemistry has been more frequently used in the development and manufacture of pharmaceuticals due to the progression of equipment and the availability of…”
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A Scale-Transparent Reaction Calorimetric Assay For Rapid Catalyst Selection by Le Bars, Joel, Häußner, Thomas, Lang, Jutta, Pfaltz, Andreas, Blackmond, Donna G.

“…The use of reaction calorimetry in a “one‐pot” catalyst screening protocol provides a rapid route to a scale‐transparent picture of catalyst activity when the…”
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Kinetic Studies of Heck Coupling Reactions Using Palladacycle Catalysts: Experimental and Kinetic Modeling of the Role of Dimer Species by Rosner, Thorsten, Le Bars, Joel, Pfaltz, Andreas, Blackmond, Donna G

“…Experimental kinetic studies of the coupling of p-bromobenzaldehyde (1) with butyl acrylate (2) using the dimeric palladacycles complex (4) with chelating…”
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A Catalytic Probe of the Surface of Colloidal Palladium Particles Using Heck Coupling Reactions by Le Bars, Joël, Specht, Ullrich, Bradley, John S, Blackmond, Donna G

“…A series of well-defined homopolymer-stabilized Pd colloids with varying metal particle size was used to study the Heck coupling reaction between aryl halides…”
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