Search Results - "Leśnikowski, Zbigniew"

IS IT TIME FOR MULTI-DRUG THERAPY WITH COMBINATION OF THERAPEUTIC NUCLEIC ACIDS? by Lesnikowski, Zbigniew Jan

“…Therapeutic nucleic acids (TNAs) are a new class of drugs that exhibit different properties and mechanisms of action from those of small molecules or…”
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Recent developments with boron as a platform for novel drug design by Leśnikowski, Zbigniew J

“…After decades of development, the medicinal chemistry of compounds that contain a single boron atom has matured to the present status of having equal rights…”
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Challenges and Opportunities for the Application of Boron Clusters in Drug Design by Leśnikowski, Zbigniew J

“…There are two branches in boron medicinal chemistry: the first focuses on single boron atom compounds, and the second utilizes boron clusters. Boron clusters…”
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DNA Modified with Boron⁻Metal Cluster Complexes [M(C₂B₉H 11 )₂]-Synthesis, Properties, and Applications by Olejniczak, Agnieszka B, Nawrot, Barbara, Leśnikowski, Zbigniew J

“…Together with tremendous progress in biotechnology, nucleic acids, while retaining their status as "molecules of life", are becoming "molecular wires",…”
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Interactions of Boron Clusters and their Derivatives with Serum Albumin by Goszczyński, Tomasz M., Fink, Krzysztof, Kowalski, Konrad, Leśnikowski, Zbigniew J., Boratyński, Janusz

“…Boron clusters are polyhedral boron hydrides with unique properties, and they are becoming increasingly widely used in biology and medicine, including for…”
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Association of TLR3 L412F Polymorphism with Cytomegalovirus Infection in Children by Studzińska, Mirosława, Jabłońska, Agnieszka, Wiśniewska-Ligier, Małgorzata, Nowakowska, Dorota, Gaj, Zuzanna, Leśnikowski, Zbigniew J, Woźniakowska-Gęsicka, Teresa, Wilczyński, Jan, Paradowska, Edyta

“…Intracellular Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA (dsRNA) and activates antiviral immune responses through the production of type…”
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High Boron-loaded DNA-Oligomers as Potential Boron Neutron Capture Therapy and Antisense Oligonucleotide Dual-Action Anticancer Agents by Kaniowski, Damian, Ebenryter-Olbińska, Katarzyna, Sobczak, Milena, Wojtczak, Błażej, Janczak, Sławomir, Leśnikowski, Zbigniew J, Nawrot, Barbara

“…Boron cluster-modified therapeutic nucleic acids with improved properties are of interest in gene therapy and in cancer boron neutron capture therapy (BNCT)…”
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TLR9 -1486T/C and 2848C/T SNPs Are Associated with Human Cytomegalovirus Infection in Infants by Paradowska, Edyta, Jabłońska, Agnieszka, Studzińska, Mirosława, Skowrońska, Katarzyna, Suski, Patrycja, Wiśniewska-Ligier, Małgorzata, Woźniakowska-Gęsicka, Teresa, Nowakowska, Dorota, Gaj, Zuzanna, Wilczyński, Jan, Leśnikowski, Zbigniew J

“…Toll-like receptor 9 (TLR9) recognizes non-methylated viral CpG-containing DNA and serves as a pattern recognition receptor that signals the presence of human…”
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Structure–Activity Relationship of para-Carborane Selective Estrogen Receptor β Agonists by Sedlák, David, Wilson, Tyler A, Tjarks, Werner, Radomska, Hanna S, Wang, Hongyan, Kolla, Jayaprakash Narayana, Leśnikowski, Zbigniew J, Špičáková, Alena, Ali, Tehane, Ishita, Keisuke, Rakotondraibe, Liva Harinantenaina, Vibhute, Sandip, Wang, Dasheng, Anzenbacher, Pavel, Bennett, Chad, Bartunek, Petr, Coss, Christopher C

“…Selective agonism of the estrogen receptor (ER) subtypes, ERα and ERβ, has historically been difficult to achieve due to the high degree of ligand-binding…”
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Comparative Study of Carborane- and Phenyl-Modified Adenosine Derivatives as Ligands for the A2A and A3 Adenosine Receptors Based on a Rigid in Silico Docking and Radioligand Replacement Assay by Vincenzi, Marian, Bednarska, Katarzyna, Leśnikowski, Zbigniew J

“…Adenosine receptors are involved in many physiological processes and pathological conditions and are therefore attractive therapeutic targets. To identify new…”
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Antiviral Effect of Nonfunctionalized Gold Nanoparticles against Herpes Simplex Virus Type-1 (HSV-1) and Possible Contribution of Near-Field Interaction Mechanism by Paradowska, Edyta, Studzińska, Mirosława, Jabłońska, Agnieszka, Lozovski, Valeri, Rusinchuk, Natalia, Mukha, Iuliia, Vitiuk, Nadiia, Leśnikowski, Zbigniew J.

“…The antiviral activity of nonfunctionalized gold nanoparticles (AuNPs) against herpes simplex virus type-1 (HSV-1) in vitro was revealed in this study. We…”
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Metallacarborane Synthons for Molecular Construction-Oligofunctionalization of Cobalt Bis(1,2-dicarbollide) on Boron and Carbon Atoms with Extendable Ligands by Śmiałkowski, Krzysztof, Sardo, Carla, Leśnikowski, Zbigniew J

“…The exploitation of metallacarboranes' potential in various fields of research and practical applications requires the availability of convenient and versatile…”
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Versatile Method for the Site‐Specific Modification of DNA with Boron Clusters: Anti‐Epidermal Growth Factor Receptor (EGFR) Antisense Oligonucleotide Case by Ebenryter‐Olbińska, Katarzyna, Kaniowski, Damian, Sobczak, Milena, Wojtczak, Błażej A, Janczak, Sławomir, Wielgus, Ewelina, Nawrot, Barbara, Leśnikowski, Zbigniew J

“…A general and convenient approach for the incorporation of different types of boron clusters into specific locations of the DNA‐oligonucleotide chain based on…”
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Synthesis of boron cluster analogs of penicillin and their antibacterial activity by Różycka, Daria, Leśnikowski, Zbigniew J., Olejniczak, Agnieszka B.

“…Antimicrobial resistance (AMR) is an exceptional increasing challenge for human health; it is urgently need to develop novel leads that can be developed to…”
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Synthesis of DNA‐Boron Cluster Composites and Assembly into Functional Nanoparticles with Dual, Anti‐EGFR, and Anti‐c‐MYC Oncogene Silencing Activity by Bednarska‐Szczepaniak, Katarzyna, Ebenryter‐Olbińska, Katarzyna, Gajek, Gabriela, Śmiałkowski, Krzysztof, Suwara, Justyna, Fiedorowicz, Lidia, Leśnikowski, Zbigniew

“…A versatile method for the automated synthesis of composites containing DNA‐oligonucleotides and boron cluster scaffolds and their assembly into functional…”
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Insight into the expression of RIG-I-like receptors in human third trimester placentas following ex vivo cytomegalovirus or vesicular stomatitis virus infection by Jabłońska, Agnieszka, Świerzko, Anna S., Studzińska, Mirosława, Suski, Patrycja, Kalinka, Jarosław, Leśnikowski, Zbigniew J., Cedzyński, Maciej, Paradowska, Edyta

“…•The third trimester placenta expressed all genes encoding RIG-I-like receptors.•The RIG-I and MDA5 expression increased in VSV-infected explants.•The…”
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Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)‐JQ1 by Hassell‐Hart, Storm, Picaud, Sarah, Lengacher, Raphael, Csucker, Joshua, Millet, Regis, Gasser, Gilles, Alberto, Roger, Maple, Hannah, Felix, Robert, Leśnikowski, Zbigniew J., Stewart, Helen J. S., Chevassut, Timothy J., Morley, Simon, Filippakopoulos, Panagis, Spencer, John

“…A series of bulky organometallic and organic analogues of the bromodomain (BRD) inhibitor (+)‐JQ1 have been prepared. The most potent,…”
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Interaction of Adenosine, Modified Using Carborane Clusters, with Ovarian Cancer Cells: A New Anticancer Approach against Chemoresistance by Bednarska-Szczepaniak, Katarzyna, Przelazły, Ewelina, Kania, Katarzyna Dominika, Szwed, Marzena, Litecká, Miroslava, Grűner, Bohumír, Leśnikowski, Zbigniew J

“…Platinum compounds remain the first-line drugs for the treatment of most lethal gynecological malignancies and ovarian cancers. Acquired platinum resistance…”
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Raman cell imaging with boron cluster molecules conjugated with biomolecules by Mochizuki, Masahito, Sato, Shinichi, Asatyas, Syifa, Le nikowski, Zbigniew J, Hayashi, Tomohiro, Nakamura, Hiroyuki

“…Raman spectroscopic measurements and theoretical calculation revealed that the Raman bands corresponding to the B-H stretching vibrations of two types of…”
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Solid state, thermal synthesis of site-specific protein-boron cluster conjugates and their physicochemical and biochemical properties by Goszczyński, Tomasz M, Kowalski, Konrad, Leśnikowski, Zbigniew J, Boratyński, Janusz

“…Boron clusters represent a vast family of boron-rich compounds with extraordinary properties that provide the opportunity of exploitation in different areas of…”
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