Search Results - "León, Beatriz"

A model of Th2 differentiation based on polarizing cytokine repression by León, Beatriz

“…Current dogma holds that functional differentiation of helper T cells expressing lineage-specifying transcription factors and signature cytokines requires…”
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Modulating Th2 Cell Immunity for the Treatment of Asthma by León, Beatriz, Ballesteros-Tato, Andre

“…It is estimated that more than 339 million people worldwide suffer from asthma. The leading cause of asthma development is the breakdown of immune tolerance to…”
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Understanding the development of Th2 cell-driven allergic airway disease in early life by León, Beatriz

“…Allergic diseases, including atopic dermatitis, allergic rhinitis, asthma, and food allergy, are caused by abnormal responses to relatively harmless foreign…”
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Compartmentalization of dendritic cell and T‐cell interactions in the lymph node: Anatomy of T‐cell fate decisions by León, Beatriz, Lund, Frances E.

“…Summary Upon receiving cognate and co‐stimulatory priming signals from antigen (Ag)‐presenting dendritic cells (DCs) in secondary lymphoid tissues, naïve CD4+…”
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Sensing of protease activity as a triggering mechanism of Th2 cell immunity and allergic disease by Meloun, Audrey, León, Beatriz

“…CD4 T-helper cell type 2 (Th2) cells mediate host defense against extracellular parasites, like helminths. However, Th2 cells also play a pivotal role in the…”
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Monocyte-Derived Dendritic Cells Formed at the Infection Site Control the Induction of Protective T Helper 1 Responses against Leishmania by Leon, Beatriz, Lopez-Bravo, Maria, Ardavin, Carlos

“…Infection-induced inflammatory reactions involve a strong increase in dendritic cells (DCs) at the infection site and draining lymph nodes (dLNs). Whether…”
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Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection by Botta, Davide, Fuller, Michael J, Marquez-Lago, Tatiana T, Bachus, Holly, Bradley, John E, Weinmann, Amy S, Zajac, Allan J, Randall, Troy D, Lund, Frances E, León, Beatriz, Ballesteros-Tato, André

“…Humoral immunity is necessary for controlling viral infection. Ballesteros-Tato and colleagues show that development of follicular regulatory T cells is…”
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T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust Mite by Ballesteros-Tato, André, Randall, Troy D., Lund, Frances E., Spolski, Rosanne, Leonard, Warren J., León, Beatriz

“…Exposure to environmental antigens, such as house dust mite (HDM), often leads to T helper 2 (Th2) cell-driven allergic responses. However, the mechanisms…”
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FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability by León, Beatriz, Bradley, John E., Lund, Frances E., Randall, Troy D., Ballesteros-Tato, André

“…Here, we test the role of FoxP3 + regulatory T cells (Tregs) in controlling T follicular helper (Tfh) and germinal centre (GC) B-cell responses to influenza…”
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CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs by Chisolm, Danielle A., Savic, Daniel, Moore, Amanda J., Ballesteros-Tato, Andre, León, Beatriz, Crossman, David K., Murre, Cornelis, Myers, Richard M., Weinmann, Amy S.

“…Despite considerable research connecting cellular metabolism with differentiation decisions, the underlying mechanisms that translate metabolite-sensitive…”
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Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cell responses to influenza by Ballesteros-Tato, André, León, Beatriz, Lund, Frances E, Randall, Troy D

“…Efficient antiviral responses require cross-priming of cytolytic T lymphocytes by dendritic cells. Randall and colleagues show that CD103 − CD11b hi dendritic…”
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Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation by Ballesteros-Tato, André, León, Beatriz, Graf, Beth A., Moquin, Amy, Adams, Pamela Scott, Lund, Frances E., Randall, Troy D.

“…T follicular helper (Tfh) cells promote T cell-dependent humoral immune responses by providing T cell help to B cells and by promoting germinal center (GC)…”
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Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants by Bachus, Holly, Kaur, Kamaljeet, Papillion, Amber M., Marquez-Lago, Tatiana T., Yu, Zhihong, Ballesteros-Tato, André, Matalon, Sadis, León, Beatriz

“…Infants have a higher risk of developing allergic asthma than adults. However, the underlying mechanism remains unknown. We show here that sensitization of…”
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Is Satoyoshi syndrome an autoimmune disease? A systematic review by Viana Abreu Montanaro, Vinícius, Solís-García del Pozo, Julián, Falcão Hora, Thiago, León, Beatriz H, de Cabo, Carlos, Solera, Javier

“…Abstract Objectives Satoyoshi syndrome is a rare multisystem disease of presumed autoimmune aetiology. We carried out a systematic review to evaluate the…”
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Monocyte-derived dendritic cells in innate and adaptive immunity by Leon, Beatriz, Ardavin, Carlos

“…Monocytes have been classically considered essential elements in relation with innate immune responses against pathogens, and inflammatory processes caused by…”
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Regulation of TH2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells by León, Beatriz, Ballesteros-Tato, André, Browning, Jeffrey L, Dunn, Robert, Randall, Troy D, Lund, Frances E

“…In lymph nodes, cellular positioning can dictate the immune response. Lund and colleagues show that nematode infection triggers interactions between…”
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GM-CSF production by non-classical monocytes controls antagonistic LPS-driven functions in allergic inflammation by Kaur, Kamaljeet, Bachus, Holly, Lewis, Crystal, Papillion, Amber M., Rosenberg, Alexander F., Ballesteros-Tato, André, León, Beatriz

“…Lipopolysaccharide (LPS) can either promote or prevent T helper 2 (Th2) cell allergic responses. However, the underlying mechanism remains unknown. We show…”
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Monocyte migration to inflamed skin and lymph nodes is differentially controlled by L-selectin and PSGL-1 by LEON, Beatriz, ARDAVIN, Carlos

“…Monocyte recruitment and differentiation into dendritic cells or macrophages play a critical role in defense mechanisms against pathogens and in inflammatory…”
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IL-17-producing B cells combat parasites by León, Beatriz, Lund, Frances E

“…Interleukin 17 (IL-17) confers protection against Trypanosoma cruzi . Surprisingly, B cells are the relevant source, producing IL-17 via a unique pathway…”
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Age Difference in the Immune Response to Endotoxin (LPS) Shapes Th2-Mediated Airway Inflammation and Development of Asthma by León, Beatriz, PhD, Ballesteros-Tato, Andre

“…According to the hygiene hypothesis, this is due to increased exposure to endotoxin (LPS) and other farm-related microorganism-derived compounds…”
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