Search Results - "Leão, Rodrigo Molini"
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Involvement of Pre-limbic Cortex-Nucleus accumbens projections in Context-Induced alcohol seeking
Published in Brain research (15-10-2024)“…[Display omitted] •Exposure to alcohol-associated contexts induced an increase in Fos-immunoreactive nuclei in the nucleus accumbens core and…”
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Maternal Separation Stress Affects Voluntary Ethanol Intake in a Sex Dependent Manner
Published in Frontiers in physiology (07-12-2021)“…Maternal separation (MS) stress is a predictive animal model for evaluating the effects of early stress exposure on alcohol use disorders (AUD). The extended…”
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Functional inactivation of the orbitofrontal cortex disrupts context-induced reinstatement of alcohol seeking in rats
Published in Drug and alcohol dependence (01-05-2018)“…•The role of orbital frontal cortex (OFC) in context-induced alcohol seeking was investigated.•Male and female rats exhibit context-induced reinstatement of…”
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Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats
Published in Addiction biology (01-01-2015)“…Tobacco dependence is associated with the emergence of negative emotional states during withdrawal, including anxiety and nociceptive hypersensitivity…”
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Dorsal hippocampus plays a causal role in context-induced reinstatement of alcohol-seeking in rats
Published in Behavioural brain research (01-02-2021)“…Drug addiction is a chronic mental disorder characterized by frequent relapses. Contextual cues associated with drug use to play a critical causal role in…”
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Effects of biperiden (cholinergic muscarinic m1/m4 receptor antagonist) on ethanol conditioned place preference in mice
Published in Neuroscience letters (06-02-2021)“…•Muscarinic cholinergic receptors may alter drug-reinforcing values related to drug craving.•Biperiden decreased expression off ethanol CPP.•Biperiden…”
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Prolonged Exposure to Alcohol Vapor Causes Change in Cardiovascular Function in Female but not in Male Rats
Published in Alcoholism, clinical and experimental research (01-06-2019)“…Background Alcohol abuse is a health concern worldwide. Studies have associated alcohol abuse with cardiovascular impairments. In this study, we investigated…”
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Stress induces behavioral sensitization, increases nicotine-seeking behavior and leads to a decrease of CREB in the nucleus accumbens
Published in Pharmacology, biochemistry and behavior (01-05-2012)“…Experimental evidence shows that exposure to stress engenders behavioral sensitization and increases drug-seeking and leads to intense drug taking. However the…”
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Stress-induced cross-sensitization to amphetamine is related to changes in the dopaminergic system
Published in Journal of Neural Transmission (01-04-2012)“…Repeated stress engenders behavioral sensitization. The mesolimbic dopamine system is critically involved in drug-induced behavioral sensitization. In the…”
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Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking
Published in The Journal of neuroscience (15-04-2015)“…Alcohol and nicotine are the two most co-abused drugs in the world. Previous studies have shown that nicotine can increase alcohol drinking in nondependent…”
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Stress-Induced Locomotor Sensitization to Amphetamine in Adult, but not in Adolescent Rats, Is Associated with Increased Expression of ΔFosB in the Nucleus Accumbens
Published in Frontiers in behavioral neuroscience (12-09-2016)“…While clinical and pre-clinical evidence suggests that adolescence is a risk period for the development of addiction, the underlying neural mechanisms are…”
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Extended access to nicotine leads to a CRF sub(1) receptor dependent increase in anxiety-like behavior and hyperalgesia in rats
Published in Addiction biology (01-01-2015)“…Tobacco dependence is associated with the emergence of negative emotional states during withdrawal, including anxiety and nociceptive hypersensitivity…”
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