Search Results - "Leão, Raquel A. C"

Continuous-flow synthesis of dimethyl fumarate: a powerful small molecule for the treatment of psoriasis and multiple sclerosis by Lima, Marcelo T, Finelli, Fernanda G, de Oliveira, Alline V. B, Kartnaller, Vinicius, Cajaiba, João F, Leão, Raquel A. C, de Souza, Rodrigo O. M. A

“…Dimethyl fumarate (DMF) is a methyl ester of fumaric acid and has recently gained attention due to its use as a pro-drug in different pharmaceutical…”
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Enhanced Productivity in Glycerol Carbonate Synthesis under Continuous Flow Conditions: Combination of Immobilized Lipases from Porcine Pancreas and Candida antarctica (CALB) on Epoxy Resins by do Nascimento, Marcelo A, Gotardo, Larissa E, Leão, Raquel A. C, de Castro, Aline M, de Souza, Rodrigo O. M. A, Itabaiana, Ivaldo

“…Among several value-added products from glycerol, glyceryl carbonate (GC) has gained prominence during the recent years because of its attractive…”
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Frontispiece: Cannabidiol Discovery and Synthesis—a Target‐Oriented Analysis in Drug Production Processes by Aguillón, Anderson R., Leão, Raquel A. C., Miranda, Leandro S. M., Souza, Rodrigo O. M. A.

“…The discovery and development of approaches toward the synthesis of cannabidiol (CBD), which has an increasing meaning as a medicine, have arisen from the…”
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Evaluation of Coumarin and Neoflavone Derivatives as HCV NS5B Polymerase Inhibitors by Nichols, Daniel B., Leão, Raquel A. C., Basu, Amartya, Chudayeu, Maksim, de Moraes, Paula de F., Talele, Tanaji T., Costa, Paulo R. R., Kaushik-Basu, Neerja

“…Coumarins and coumestans represent an important family of compounds with diverse pharmacological properties. We recently identified coumestans as novel…”
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Cannabidiol Discovery and Synthesis—a Target‐Oriented Analysis in Drug Production Processes by Aguillón, Anderson R., Leão, Raquel A. C., Miranda, Leandro S. M., Souza, Rodrigo O. M. A.

“…The current state of evidence and recommendations for cannabidiol (CBD) and its health effects change the legal landscape and aim to destigmatize its…”
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Levoglucosenone as a starting material for cascade continuous-flow synthesis of (R)-γ-carboxy-γ-butyrolactone by Pacheco, Caio M, Lima, Wesley, Lima, Fernanda A, Gomez, Mauro R B P, da Silva, Isabela G, Miranda, Leandro S M, Esteves, Pierre M, Itabaiana, Jr, Ivaldo, Wojcieszak, Robert, Leão, Raquel A C, de Souza, Rodrigo O M A

“…The global imperative to shift towards renewable and sustainable resources has spurred significant interest in exploring and utilizing platform chemicals…”
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α‐Ketobutyrate Production under Continuous‐Flow Conditions Catalyzed by Immobilized L‐Methionine γ‐Lyase by Jorge, Jessica M., M. Silva, Marcus V., Brêda, Gabriela C., Souza, Camilla P., Leão, Raquel A. C., Almeida, Rodrigo V., Bornscheuer, Uwe T., Souza, Rodrigo O. M. A.

“…l‐Methionine γ‐lyase (MGL) is a PLP‐dependent enzyme which catalyzes the α, γ‐elimination reaction in sulfur containing amino acids, such as L‐methionine and…”
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Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients by Aguiar, Renata M, Leão, Raquel A C, Mata, Alejandro, Cantillo, David, Kappe, C Oliver, Miranda, Leandro S M, de Souza, Rodrigo O M A

“…Continuous-flow production of chiral intermediates plays an important role in the development of building blocks for Active Pharmaceutical Ingredients (APIs),…”
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Lipase-catalyzed acylation of levoglucosan in continuous flow: antibacterial and biosurfactant studies by do Nascimento, Marcelo A, Vargas, Juan P C, Rodrigues, José G A, Leão, Raquel A C, de Moura, Patricia H B, Leal, Ivana C R, Bassut, Jonathan, de Souza, Rodrigo O M A, Wojcieszak, Robert, Itabaiana, Jr, Ivaldo

“…Studies involving the transformation of lignocellulosic biomass into high value-added chemical products have been intensively conducted in recent years. Its…”
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Continuous Flow Synthesis of Hexyl Laurate Using Immobilized Thermomyces Lanuginosus Lipase from Residual Babassu Mesocarp by Lira, Regiane K de S, do Nascimento, Marcelo A, Lima, Marcelo Tavares, Georgii, Ana Débora N P, Leão, Raquel A C, de Souza, Rodrigo O M A, Wojcieszak, Robert, Leite, Selma G F, Itabaiana, Jr, Ivaldo

“…This work applied BM as support for immobilization of lipase TLL in packed-bed reactor and its application for the synthesis of hexyl laurate. Initially, the…”
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Continuous-Flow Sequential Schotten–Baumann Carbamoylation and Acetate Hydrolysis in the Synthesis of Capecitabine by Miranda, Leandro S. de M, de Souza, Rodrigo O. M. A, Leão, Raquel A. C, Carneiro, Paula F, Pedraza, Sergio F, de Carvalho, Otavio V, de Souza, Stefânia P, Neves, Rebeca V

“…Capecitabine is an important anticancer drug whose synthesis comprises late-stage carbamoylation and ester hydrolysis. Herein we report the use of the…”
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Continuous‐Flow Synthesis of (R)‐Propylene Carbonate: An Important Intermediate in the Synthesis of Tenofovir by Suveges, Nicolas S., Rodriguez, Anderson A., Diederichs, Carla C., de Souza, Stefania P., Leão, Raquel A. C., Miranda, Leandro S. M., Horta, Bruno A. C., Pedraza, Sérgio F., de Carvalho, Otavio V., Pais, Karla C., Terra, José H. C., de Souza, Rodrigo O. M. A.

“…(R)‐Propylene carbonate is an important intermediate in the synthesis of tenofovir pro‐drugs such as tenofovir alafenamide fumarate (TAF) and tenofovir…”
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From Immobilization to Catalyst Use: A Complete Continuous‐Flow Approach Towards the Use of Immobilized Organocatalysts by Oliveira, Pedro H. R., S. Santos, Bruno M., Leão, Raquel A. C., Miranda, Leandro S. M., San Gil, Rosane A. S., Souza, Rodrigo O. M. A., Finelli, Fernanda G.

“…The combination of chiral supported‐organocatalysts and flow chemistry promotes the sustainable production of enantioenriched compounds providing a very…”
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Immobilization of lipase B from Candida antarctica on epoxy‐functionalized silica: characterization and improving biocatalytic parameters by de Souza, Stefânia P, de Almeida, Rayza AD, Garcia, Gabriel G, Leão, Raquel AC, Bassut, Jonathan, de Souza, Rodrigo OMA, Itabaiana, Ivaldo

“…BACKGROUND In this work, lipase B from Candida antarctica (CaLB) was immobilized on Purolite® ECR8205F, Purolite® ECR8214F and Immobead® IB150 P epoxy resins…”
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Microwave-Promoted Palladium-Catalysed Oxyarylation of Dihydronaphthalene and Chromenes by o-Iodophenols and Its Acetates by Leão, Raquel A. C., Pinho, Vagner D., Coelho, Artur S., Buarque, Camilla D., Moraes, Paula F., Alonso, Diego A., Nájera, Carmen, Costa, Paulo R. R.

“…The oxyarylation of dihydronaphthalene (1a), two electron‐rich (1b,c) and one electron‐poor (2) chromenes with different o‐iodophenols and their acetates 3a–h…”
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Immobilization of lipases on lignocellulosic bamboo powder for biocatalytic transformations in batch and continuous flow by G. Palma, Bruna, C. Leão, Raquel A., M.A. de Souza, Rodrigo O., G. Pandoli, Omar

“…[Display omitted] •Physical immobilized lipases on pristine cost-effective bamboo powder.•Fatty acid esterification and olive oil hydrolysis in batch…”
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Molecular Modeling of a Phenyl-Amidine Class of NMDA Receptor Antagonists and the Rational Design of New Triazolyl-Amidine Derivatives by Abreu, Paula A., Castro, Helena C., Paes-de-Carvalho, Roberto, Rodrigues, Carlos R., Giongo, Viveca, Paixão, Izabel C. N. P., Santana, Marcos V., Ferreira, Jainne M., Caversan, Octavia M., Leão, Raquel A. C., Marins, Luana M. S., Henriques, André M., Farias, Florence M. C., Albuquerque, Magaly G., Pinheiro, Sergio

“…Recently, many efforts have been made to develop N‐methyl‐d‐aspartic acid receptor antagonists for treating different pathological conditions such as…”
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Process Intensification for Obtaining a Cannabidiol Intermediate by Photo-oxygenation of Limonene under Continuous-Flow Conditions by Aguillón, Anderson R., Leão, Raquel A. C., de Oliveira, Kleber Thiago, Brocksom, Timothy John, Miranda, Leandro S. M., de Souza, Rodrigo O. M. A.

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Functionalization of unsaturated carbon–carbon bonds by continuous-flow ozonolysis by Pacheco, Caio M., Lima, Fernanda A., Gomez, Mauro R. B. P., Barbosa, Lucas B., Leão, Raquel A. C., de Souza, Rodrigo O. M. A.

“…In the continuous struggle for improvements in laboratory processes, flow synthesis has been widely used for being safer, more reproducible, as for improving…”
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A New Insight into the Catalytic Decomposition of Ethyl Diazoacetate in the Presence of meso-Tetraarylporphyrin (=5,10,15,20-Tetraaryl-21H,23H-porphine) Complexes by Gomes, Ana T. P. C., Leão, Raquel A. C., Alonso, Cristina M. A., Neves, Maria G. P. M. S., Faustino, Maria A. F., Tomé, Augusto C., Silva, Artur M. S., Pinheiro, Sergio, de Souza, Maria Cecília B. V., Ferreira, Vítor F., Cavaleiro, José A. S.

“…The decomposition of ethyl diazoacetate by several catalysts in the presence of meso‐tetraarylporphyrin complexes with different electronic features was…”
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